Antidepressants Medical Presentation

Antidepressants PowerPoint Presentation

DOWNLOAD MEDICAL POWERPOINT PRESENTATION

About This Presentation

Description : Download Free Antidepressants medical powerpoint (ppt) presentation for your medical ppt presentation

Tags : antidepressent

Published on : May 11, 2019 | Views : 2674 | Downloads : 2

Shareable Url :

Embed Code :

Comment

Transcript

Slide 1-

Antidepressants
Slide 2-

The term depression refers to a depression of mood as is a chronic condition. Depression mood is accompanied by: low energy or fatigue sleep disturbances. Physical, social, and personal functioning are impaired. The risk of suicide is greatly increased.
Slide 3-

Types of depression
Slide 4-

Our target : When depression occurs, there may be a decreased amount of these two chemicals released from nerve cells in the brain So we have to inhibit the neurotransmitter break down
Slide 5-

ppt slide no 5 content not found
Slide 6-

Monoamine Oxidase Inhibitors plays the physiological role of oxidatively deaminating primary and secondary amines to aldehydes, ammonia neurotransmitter amines are deaminated primarily by type A, benzylamine by type B and tyramine by both type A and B MAO.
Slide 7-

Mechanism of Action: Inhibit MAO which catabolizes biogenic amines Side Effects: food containing tyramine (Cheese) leads to hypertensive crisis (Cheese effect) dryness of mouth, excessive perspiration, dizziness, blurred vision, nausea, constipation,hepatitis
Slide 8-

•A consequence of irreversible inactivation is that the action of the agents may continue for up to 2 weeks after administration is discontinued. Uses: atypical depressive illness they are drugs of second choice
Slide 9-

MAO inhibitors are divided into three groups: a)First generation MAO inhibitors: Irreversible Non-Selective MAOIs (e.g. iproniazide). b)Second generation MAO inhibitors: Irreversible Selective MAOIs c)Third generation: reversible Selective MAOIs
Slide 10-

a)First generation MAO inhibitors a)Iproniazid: Synthesis :
Slide 11-

Mechanism of action
Slide 12-

b) Phenelzine Sulphate Mechanism of action
Slide 13-

Tranylcypromine Mechanism of action
Slide 14-

L Deprenyl (Selegiline) Selegiline inhibits MAOB Irreversible Selective USES In its pill form, selegiline is used to treat symptoms of Parkinson's disease Selegiline is also delivered via a transdermal patch in this form it is used as a treatment for major depressive disorder
Slide 15-

Synthesis:
Slide 16-

Third generation MAO inhibitors: Reversible Selective MAOIs Moclobemide It is safer than irreversible MAOIs (less hypertensive crisis Synthesis:
Slide 17-

Tricyclic Antidepressants Mechanism of Action Tricyclic antidepressants potentiate the action of biogenic amines (mainly NA and 5-HT) by inhibiting their presynaptic uptake after release which leads to increased concentrations of these neurotramsmitters at the synapse.
Slide 18-

Side Effects: They block Cholinergic and histamine receptors, it has marked anticholinergic & sedative effects. Advantage: They are safer than MAOI , used with no diet control and used for children (bed wetting).
Slide 19-

1) Imipramine used in the treatment of major depression and enuresis (Nocturnal Enuresis) bed wetting. it has marked anticholinergic & sedative effects It is an Azepine Derivative
Slide 20-

Imipramine Synthesis
Slide 21-

SAR
Slide 22-

2) Desipramine It is a demethylated metabolite of imipramine with less anticholinergic, less sedative , more stimulatory
Slide 23-

Metabolism
Slide 24-

Clomipramine It is up to 50 Times as potent as imipramine
Slide 25-

4) Amitriptyline Double bond is responsible for rigidification. No geometric isomers. More potent than imipramine
Slide 26-

5) Nortriptyline less anticholinergic, less sedative & more stimulant action than amitriptyline. Nortriptyline is a SNERI
Slide 27-

Amitryptiline, Dothepine & Doxepine are bio- isosters
Slide 28-

Tetracyclic Antidepressants Morprotilin less cardiac side effects It can be viewed as a TCA with an ethylene-bridged central ring
Slide 29-

Selective Serotonin reuptake inhibitor Fluoxetine Synthesis :
Slide 30-

Metabolism
Slide 31-

Selective Norepinephrine Reuptake Inhibitors
Slide 32-

Lab 2.1