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Introduction To Pharmacogenomics And Personalized Medicine PowerPoint Presentation

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Description : Check out this medical PowerPoint presentation titled "Introduction to Pharmacogenomics and Personalized Medicine".
This medical PowerPoint presentation talks about Pharmacogenomics, the study of how genetic variations influence an individuals response to drugs. It involves the analysis of the interplay between a persons genetics and the drugs they take. By studying how genetic variations affect drug metabolism, efficacy, and toxicity, pharmacogenomics can help healthcare professionals tailor treatment plans to each patients individual needs.

Tags : Pharmacogenomics, genetic variations, pharmacology, genomics, Genetics, Genetics PowerPoint presentation

Published on : Mar 27, 2023 | Views : 1218 | Downloads : 0

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Slide 1-

Introduction to Pharmacogenomics and Personalized Medicine By: Mai Mehanna, MS, BCPS
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Interindividual Variability of Drug Responses Variability in treatment response to medications (Efficacy) Variability in adverse effects in response to medications (Toxicity)
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Sources of Variation in Response Variability in Drug Response Age Disease States Environmental Factors Drug Interactions Pregnancy Obesity Gender Adherence Genetic Differences Race Pharmacogenomics
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How Genetic Variations affect Drug’s Response Genetic variations can affect either the drug’s pharmacokinetics (PK) or the pharmacodynamics (PD)
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Pharmacogenetics vs. Pharmacogenomics Pharmacogenetics: SINGLE gene Pharmacogenomics: MULTIPLE genes
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PharmacogeneticsHistorical Perspective First complete report of an inherited difference in response to a xenobiotic in 1932 Primaquine (antimalarial drug)-induced hemolysis in some soldiers during the world war II
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PharmacogeneticsHistorical Perspective
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PharmacogeneticsHistorical Perspective The term ‘Pharmacogenetics’ was coined as ‘the inherited difference in drug response’ by Freidrich Vogel, Germany – 1959
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PharmacogeneticsHistorical Perspective 1970’s-1990s: many drug-gene interactions have been studied and investigated The development of pharmacogenetics over the years ‘Pharmacogenomics’ & the emergence of the Human Genome Project
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Human Genome Project(1990-2003) The world’s largest collaborative biological project, costed about $3-billion 20 universities and research centers around the world Goals determining the sequence of the human DNA and identifying all of the genes (structure, function)
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Genomic Achievements since the Human Genome Project 2005 First FDA approval of a pharmacogenetic test 2006 First direct-to-consumer whole-genome test 2007 the FDA started to recognize the importance of pharmacogenomics, issued black box warnings, incorporated genotype-guided dosing algorithms, and included pharmacogenomic information in drug labeling 2008 Genetic Information Nondiscrimination Act (GINA) passed in U.S
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Published Genome-Wide Association Reports, 2005-2013
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Personalized Medicine Precision Medicine, Individualized Therapy, Stratified Medicine Definition
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Traditional vs. Personalized Treatment
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Potential Benefits of Personalized Medicine Improve drug’s efficacy Decrease drug’s adverse events Savings: time, money, illness
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Personalized Medicine Future
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Precision Medicine Initiative (PMI)2015
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Precision Medicine Initiative (PMI)2015 $ 215 investment in the NIH, FDA, and the National Coordinator for Health Information Technology Aim understand how a person’s genetics, environment, and lifestyle can help determine the best approach to prevent or treat disease Goals: Short-term expanding precision medicine in the area of cancer research Long-term bringing precision medicine to all areas of healthcare on a large scale