Download Free Medical Immunodeficiency PowerPoint Presentation

Immunodeficiency PowerPoint Presentation

DOWNLOAD MEDICAL POWERPOINT PRESENTATION

About This Presentation

Description : Check out this medical presentation on Ataxia-Telangiectasia, which is titled "Immunodeficiency", to know about immunodeficiency, its classification (specific non specific & primary and secondary), B cell deficiency & examples, T Cell deficiency & examples, SCID, and drug induced immunodeficiency.

Tags : Ataxia-Telangiectasia, Immunodeficiency, classification, B cell deficiency, T Cell deficiency, SCID, drug induced

Published on : May 10, 2021 | Views : 2738 | Downloads : 1

Shareable Url :

Embed Code :

Comment

Transcript

Slide 1-

IMMUNODEFICIENCY Lecture Outlines Define immunodeficiency Classification Specific non specific Primary and secondary B cell deficiency & Examples T Cell deficiency & Examples SCID Drug induced immunodeficiency
Slide 2-

ppt slide no 2 content not found
Slide 3-

It is the absence or failure of normal function of one or more elements of the immune system Results in immunodeficiency disease Can be specific or non specific Specific = Abnormalities of B & T cells Non specefic = Abnormalities of non specific components PRIMARY OR SECONDARY
Slide 4-

PRIMARY IMMUNODEFICIENCIES Primary immunodeficiencies are inherited defects of the immune system These defects may be in the specific or nonspecific immune mechanisms They are classified on the basis of the site of lesion in the developmental or differentiation pathway of the immune system
Slide 5-

B CELL DEFICIENCY X liked a gammaglobuinemia IgA deficiency IgG subclass deficiency Immunodeficiency with increased Igm Common variable immundeficiency Transient hypogammaglobulinaemia of infancy
Slide 6-

1- X-linked a gammaglobulinaemia In X-LA early maturation of B cells fails Affect males Few or no B cells in blood Very small lymph nodes and tonsils No Ig Small amount of Ig G in early age Recurrent pyogenic infection
Slide 7-

2- IgA and IgG subclass defeciency IgA deficiency is most common Patients tend to develop immune complex disease About 20% lack IgG2and IgG4 Susceptible to pyogenic infection Result from failure in terminal differentiation of B cells
Slide 8-

3- Immunodfeiciency with increased IgM (HIgM) Results in patients with IgA and IgG deficiency Production of large amount of IgM >200mg/dl of polyclonal IgM Susceptible to pyogenic infection Treatment by iv gamma globulin Formation of IgM to neutrophils, platelets and other blood components Due to inability of B cells to isotype switching
Slide 9-

4- Common Variable Immunodeficiency (CVID) There are defect in T cell signaling to B cells Acquired a gammaglobulinemia in the 2nd or 3rd decade of life May follow viral infection Pyogenic infection 80% of patients have B cells that are not functioning B cells are not defective. They fail to receive signaling from T lymphocytes Unknown
Slide 10-

5- Hypogamaglobulinaemia of infancy Due to delay in in IgG synthesis approximately up to 36 months In normal infants synthesis begins at 3 months Normal B lymphocytes Probably lack help of T lymphocytes
Slide 11-

DISORDERS of T CELLS DiGeorge's syndrome: It the most understood T-cell immunodeficienc Also known as congenital thymic aplasia/hypoplasia Associated with hypoparathyroidism, congenital heart disease, fish shaped mouth. Defects results from abnormal development of fetus during 6th-10th week of gestation when parathyroid, thymus, lips, ears and aortic arch are being formed
Slide 12-

T cell deficiencies with variable degrees of B cell deficiency 1- Ataxia-telangiectasia: Associated with a lack of coordination of movement (ataxis) and dilation of small blood vessels of the facial area (telangiectasis). T-cells and their functions are reduced to various degrees. B cell numbers and IgM concentrations are normal to low.
Slide 13-

IgG is often reduced IgA is considerably reduced (in 70% of the cases). There is a high incidence of malignancy, particularly leukemia in these patients. The defects arise from a breakage in chromosome 14 at the site of TCR and Ig heavy chain genes
Slide 14-

2- Wiskott-Aldrich syndrome: Associated with normal T cell numbers with reduced functions, which get progressively worse. IgM concentrations are reduced but IgG levels are normal Both IgA and IgE levels are elevated. Boys with this syndrome develop severe eczema. They respond poorly to polysaccharide antigens and are prone to pyogenic infection.
Slide 15-

MHC DEFICIENCY (Bare leukocyte syndrome): Due to defect in the MHC class II transactivator (CIITA) protein gene, which results in a lack of class-II MHC molecule on APC. Patients have fewer CD4 cells and are infection prone !. There are also individuals who have a defect in their transport associated protein (TAP) gene and hence do not express the class-I MHC molecules and consequently are deficient in CD8+ T cells.
Slide 16-

Defects of the phagocytic system Defects of phagocytic cells (numbers and/or functions) can lead to increased susceptibility to a variety of infections. 1- Cyclic neutropenia: It is marked by low numbers of circulating neutrophil approximately every three weeks. The neutropenia lasts about a week during which the patients are susceptible to infection. The defect appears to be due to poor regulation of neutrophil production.
Slide 17-

2- Chronic granulomatous disease (CGD): CGD is characterized by marked lymphadenopathy, hepato- splenomegaly and chronic draining lymph nodes. In majority of patients with CGD, the deficiency is due to a defect in NADPH oxidase that participate in phagocytic respiratory burst.
Slide 18-

3- Leukocyte Adhesion Deficiency: Leukocytes lack the complement receptor CR3 due to a defect in CD11 or CD18 peptides and consequently they cannot respond to C3b opsonin. Alternatively there may a defect in integrin molecules, LFA-1 or mac-1 arising from defective CD11a or CD11b peptides, respectively. These molecules are involved in diapedesis and hence defective neutrophils cannot respond effectively to chemotactic signals.
Slide 19-

4- Chediak-Higashi syndrome: This syndrome is marked by reduced (slower rate) intracellular killing and chemotactic movement accompanied by inability of phagosome and lysosome fusion and proteinase deficiency. Respiratory burst is normal. Associated with NK cell defect, platelet and neurological disorders
Slide 20-

Disorders of complement system: Complement abnormalities also lead to increased susceptibility to infections. There are genetic deficiencies of various components of complement system, which lead to increased infections. The most serious among these is the C3 deficiency which may arise from low C3 synthesis or deficiency in factor I or factor H.
Slide 21-

SEVERE COMBINED IMMUNODEFICENCY In about 50% of SCID patients the immunodeficiency is x-linked whereas in the other half the deficiency is autosomal. They are both characterized by an absence of T cell and B cell immunity and absence (or very low numbers) of circulating T and B lymphocytes. Patients with SCID are susceptible to a variety of bacterial, viral, mycotic and protozoan infections.
Slide 22-

The x-linked SCID is due to a defect in gamma-chain of IL-2 also shared by IL-4, -7, -11 and 15, all involved in lymphocyte proliferation and/or differentiation. The autosomal SCIDs arise primarily from defects in adenosine deaminase (ADA) or purine nucleoside phosphorylase (PNP) genes which results is accumulation of dATP or dGTP, respectively, and cause toxicity to lymphoid stem cells
Slide 23-

Diagnosis Is based on enumeration of T and B cells and immunoglobulin measurement. Severe combined immunodeficiency can be treated with bone marrow transplant
Slide 24-

SECONDARY IMMUBODEFICIENCY
Slide 25-

IMMUNODEGECIENCY CAUSED BY DRUGS CORTICOSTEROIDS Cause changes in circulating leukocytes Depletion of CD4 cells Monocytopenia Decreased in circulating eosinophils and basophils Inhibition of T cell activation and B cell maturation Inhibit cytokine synthesis
Slide 26-

METHOTREXATE Structural analogue of folic acid Blocks folic acid dependent synthetic pathways essential for DNA synthesis Prolonged use for treatment reduces immunoglobulin synthesis
Slide 27-

CYCOLOSPORIN Have severe effects on T cell signaling and functions It binds to immunophilins which are believed to have a critical role in signal transduction Also inhibit IL 2 dependent signal transduction
Slide 28-

OTHER CAUSES Malnutrition Minerals Vitamins Obesity