Download Free Medical Genetics: For this Generation and the Next PowerPoint Presentation

Genetics: For this Generation and the Next PowerPoint Presentation

DOWNLOAD MEDICAL POWERPOINT PRESENTATION

About This Presentation

Description : Check out this medical presentation on Familial Pancreatic Cancer, which is titled "Genetics: For this Generation and the Next", to know how genetics can help us identify the people who have risks for disease that go far above the general risks.

Tags : Familial Pancreatic Cancer, Genetics, risks, disease

Published on : May 18, 2021 | Views : 2487 | Downloads : 3

Shareable Url :

Embed Code :

Comment

Transcript

Slide 1-

Genetics: For this Generation and the Next Andrea Forman, MS, LCGC Fox Chase Cancer Center Risk Assessment Program Department of Clinical Genetics
Slide 2-

Common Diseases Cancer Heart disease Diabetes Hypertension Stroke Alzheimer's Arthritis Osteoporosis
Slide 3-

Common Risk Factors Age Family history Ethnicity Lifestyle Diet Alcohol Smoking
Slide 4-

Top 5 Reasons to Know Your Family History 5. Family recipes should be kept secret — family medical history should not. 4. Knowing your risk might save your life. 3. It’s free and you don’t have to leave home. 2. It’s a priceless gift to leave to your children. 1. Because every family has a story, but not every family has YOUR story. https://www.yahoo.com/health/10-reasons-you-should-dig-into-your-family-medical-118232923367.html
Slide 5-

Genetic information is key
Slide 6-

ppt slide no 6 content not found
Slide 7-

What is a Gene?
Slide 8-

DAD MOM
Slide 9-

ppt slide no 9 content not found
Slide 10-

ppt slide no 10 content not found
Slide 11-

ppt slide no 11 content not found
Slide 12-

Cancer and Genetics
Slide 13-

Fortune Cookie Tip #1 Family history was the first genetic test
Slide 14-

Clues: Genetic Risk for Cancer YOUNG Breast <45, Colon <50 RARE Examples include Ovarian, Male Breast, Pancreatic MULTIPLE Two or more different cancers in the same person FAMILY Two or more family members with the same or related types of cancer. Breast/Ovary. Breast/Thyroid/Uterine. Breast/Sarcoma/Brain
Slide 15-

Colon, 72 Sporadic Family History Risk for cancer is AVERAGE
Slide 16-

Familial Family History Prostate, 75 Lung, 65 coal miner Stomach, 55 H. pylori Liver, 50 alcohol abuse Cervix HPV, smoker Lung, 58 smoker Basal Cell sun exposure Risk for cancer is MODERATE
Slide 17-

Hereditary Family History Breast, 55 Ovarian, 44 Breast, 34 Prostate, 59 Breast, 50 Risk for cancer is HIGH
Slide 18-

Fortune Cookie Tip #2 Don’t forget to look at both sides of the family!
Slide 19-

Why would I want to know? Possible risk of another, new cancer Risks to your children Risks to other family members Screening and prevention are often available and may save a life
Slide 20-

ppt slide no 20 content not found
Slide 21-

ppt slide no 21 content not found
Slide 22-

Family history of breast cancer? Who is the best person to test? New yellow apple Red apple tree growing one yellow apple Courtesy of Kallie Weinan, MS, CGC Red apple tree growing red apples
Slide 23-

Fortune Cookie Tip #3 When searching for something rare, start the search with the most likely target.
Slide 24-

BRCA1 + BRCA1 - Does not want testing BRCA1 + BRCA1 -
Slide 25-

Cancer Risks with HBOC
Slide 26-

What Can You Do? Increased screening Start Earlier 25yo for breast screening More Often Alternating imaging every 6 months More Aggressive Mammogram + Breast MRI Prevention Medication Tamoxifen (breast cancer risk) Birth control pills (ovarian cancer risk) Surgery Risk reducing mastectomy Salpingo-oophorectomy (removal of ovaries and fallopian tubes)
Slide 27-

Guess what?
Slide 28-

You won’t be seeing many tests for just BRCA1/2 anymore
Slide 29-

ppt slide no 29 content not found
Slide 30-

ppt slide no 30 content not found
Slide 31-

Multi-Gene (NGS) Panels Genetic tests to look at dozens of genes related to cancer Similar cost and turn around time as gene specific testing Higher risk of uncertain results
Slide 32-

NGS Panels- Breast Walsh et. al. 2013 (ASHG Platform Presentation) 800 families with negative BRCA1/2 testing 206 tested positive with NGS BROCA panel (26%) Of the 26% with a new positive results 39% (80/206) had BRCA1/2 mutations 37% carried mutations in CHEK2, PALB2, or TP53 20% carried mutations in 10 less characterized genes
Slide 33-

ppt slide no 33 content not found
Slide 34-

Ms. Smith 46 year old woman with a newly diagnosed left breast cancer ER/PR+ invasive ductal carcinoma Referred to Risk Assessment as patient wants risk estimate to help her make a decision about bilateral mastectomy
Slide 35-

NGS Test Result Positive for a gene mutation CHEK2 Variants of Uncertain Significance BRCA 2 STK11
Slide 36-

Fortune Cookie Tip #4 Sometimes, in our quest for answers, we end up with more questions
Slide 37-

Moderate Risk Genes Cancer risks may not be very high How high does risk need to be before we pursue surgery or medications? Cancer risks may be unclear How do we make medical decisions when we don’t know the risks? We’re still learning The recommendations you get today may be different in 5 years
Slide 38-

NGS Test Result Positive for a gene mutation CHEK2 Variants of Uncertain Significance BRCA 2 STK11
Slide 39-

N=398
Slide 40-

ppt slide no 40 content not found
Slide 41-

Rates of Uncertain Variants Eggington et. al. Current Variant of Uncertain Significance Rates in BRCA1/2 and Lynch Syndrome Testing (MLH1, MSH2, MSH6, PMS2, EPCAM), March 2012, ACMG Poster Presentation.
Slide 42-

Isn’t it just a blood test? Positive results with limited information Inconclusive results Results that don’t “fit” Worry/anxiety
Slide 43-

Consider This… Unclear results Limited data Limited usefulness Changes in technology BENEFITS Anxiety/ distress Privacy Appropriate follow-up? Clarification of risk Guidance for medical management Information for family RISKS LIMITATIONS
Slide 44-

ppt slide no 44 content not found
Slide 45-

What can you do? Know your family history Educate your family about its history Talk to your doctor or a genetic counselor
Slide 46-

What is a Genetic Counselor?
Slide 47-

I am a translator
Slide 48-

NSGC: www.nsgc.org
Slide 49-

ppt slide no 49 content not found
Slide 50-

Questions? Andrea Forman, MS, LCGC Genetic Counselor Department of Clinical Genetics, Fox Chase Cancer Center 1-877-627-9684 www.fccc.edu/rap rapinfo@fccc.edu