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Change Your Genes – Change Your Life Sorting Hope from Hype in Genetics PowerPoint Presentation

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Description : This medical presentation on "Change Your Genes – Change Your Life Sorting Hope from Hype in Genetics " was delivered during Global Wellness Summit. The presentation talks about Epigenetics Era, Single Nucleotide Polymorphisms, Common Genetic Variants, SNPs etc.

Tags : wellness, medical, healthcare, Genes, DNA, Epigenetics Era, Single Nucleotide Polymorphisms, Common Genetic Variants, SNPs

Published on : Jul 19, 2020 | Views : 1583 | Downloads : 2

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Change Your Genes – Change Your Life Sorting Hope from Hype in Genetics Global Wellness Summit (GWS) Kenneth R. Pelletier, PhD, MD Clinical Professor of Medicine Clinical Professor of Family & Community Medicine Professor of Public Health University of Arizona School of Medicine University of California School of Medicine, San Francisco (UCSF Med)
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Epigenetics Era Health Biomarkers vs Disease Prediction Genomics Study of the entire genome (Sequencing, Mapping & Interactions) Epigenomics Study of post-translational genetics modiﬁcations Metabolomics (Genetic Expression) Study of the complete set of metabolites or small molecules (Metabolic Intermediates, Byproducts, Hormones, Signaling Compounds) present in a cell or organism Microbiome: Study of all the microbes in and on a person
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Epigenetics: A Tripartite Assay = = =
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Single Nucleotide Polymorphisms: Common Genetic Variants SNPs SNPs act as a rheostat to express or suppress genetic predisposition Genetic Variation: central to personalized medicine SNPs inﬂuence by diet/nutrition, stress/meditation, radiation, physical and psychosocial. environment, Rxs, and sense of purpose >3 million SNPs identiﬁed Estimated potential 10+ million SNPs in the human genome SNPedia: 83,452 reference SNPs
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A Tripartite Assay Pilot Study Stool Microbiome, Pathogens, and Infectious Agents Among Olympic and Elite Athletes PURPOSE: Olympic athletes, non-Olympic elite athletes, and other active adults may have genetic and metabolic profiles that are unique. These profiles may contribute to the caliber of their performance, and they may provide keys to understanding select genetic and metabolic conditions. For further details: Ms Kathrin E. Nikolussi Chief Business Development Officer kathrin.nikolussi@wellnessfx.com
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What Do We Test? Whole genome base mapping using next generation sequencing technology SNP based and whole gene based analytics Genetics More than 100 key blood biomarkers covering all key health and wellness problems Blood Genome sequencing based microbiome and metabolomics analysis for up to 300 key biomarkers Microbiome
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Genetic biomarker selection criteria: Gene biomarkers are stable from one time of testing to the next by the same laboratory. Genes are stable unless there is a speciﬁc intervention that alters them; Changes can be made in the expression of these genes by actionable, modiﬁable, self care lifestyle interventions; Changes can be detected in a maximum time frame of 10-12 weeks although many change in a matter of hours or days; and Are commercially available. EPIGENESIS Research Project
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EPIGENESIS: 7 Pillars of Optimal Health Methylation: Inﬂammation: Oxidative Stress: Detoxiﬁcation: Immunity: Lipid Metabolism: Mineral Metabolism: Methyl (CH3) molecules with genes on and oﬀ to govern DNA expression Acute vs. chronic and destructive Excessive oxidation (PON1 and SOD2) Phase one and Phase two breakdown and excretion of toxins Diﬀerentiate self from not self with hypo- and hyper- immunity Genetic expressions govern optimal lipid metabolism Govern metabolism of nutrients and trace element from whole foods
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Inflamation Moderate High IBD Lactose Intolerance Gluton Intolerance Low Low There are certain known microbial signatures that are closely associated with a number of conditions. Ut iriure tincidunt consectetuer tation macto immitto praemitto ludus venio. Luptatum minim autem lobortis vindico fatua autem epulae. Dolore paratus olim plaga dolore duis aliquip demoveo importunus importunus defui meus. Ratis roto ad neque wisi ut opto. Phyla Level Relative Abundance & Diversity Ut iriure tincidunt consectetuer tation macto immitto praemitto ludus venio. Luptatum minim autem lobortis vindico fatua autem epulae. Dolore paratus olim plaga dolore duis aliquip demoveo importunus importunus defui meus. Ratis roto ad neque wisi ut opto. Relative Abundance Diversity Firmicutes Evenness Richness Normal Important Genus & Species Diversity Genus Bacteroides Normal Moderate Good Tenericutes Normal Bacteroidetes Cyanobacteria Amino Acid that aids in… Proteobacteria Low Low Low Present Fusobacteria Breaks down food Actinobacteria Normal Verrucomicrobia High Ruminococcaceae Ruminococcaceae Gene GC,rs 2282679 Gene GC,rs 2282679 Folate Folate RBC Magnesium RBC Magnesium Vitamin D Vitamin D Example Phenotype Signature Your Signature Enterobacteriaceae Enterobacteriaceae alpha diversity HbA1c alpha diversity HbA1c Hypothetical Example Factors Score Signature Map Your data compared to Healthy/Baseline 21 % down 11 % up 5 % down Insignificant Difference Insignificant Difference 15 % down Factors Enterobacteriaceae HBA1c Ruminococcaceae Gene GC, rs 2282679 Folate RBC Magnesium Alpha Diversity 25 % down Summary Your Data Important Factors for this Phenotype Type 2 Diabetes Enterobacteriaceae HbA1c Ruminococcacea e Gene GC, rs2282679 presence 2 hours Oral intake Blood Glucose PPAR-R Vitamin D Fasting Blood Glucose Microbiome Genetics Blood DATA ANALYTICS: GENETICS, BLOOD, AND MICROBIOME
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THE MICROBIOME: KEY TO LIFE There are about one trillion bacteria living in the GI tract, ten times higher than the total amount of cells composing the human body. GI tract Reproductive tract Skin Eyes Ears
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System Summary Foundation 1 Ingestion Sensor Foundation 2 Wearable Sensor Foundation 3 Mobile Applications What it identiﬁes That a speciﬁc pill, tablet or other ingested product (or combination) was ingested. Composed and powered entirely from materials found in the daily diet. What it senses Precise time & identity of ingestions. Certain physiologic responses and consumer behaviors over time. –HR, HRV, activity, sleep, temperature. Acts as communications hub between ingested product and phone. What it inﬂuences Consumer reported wellness metrics. Correlations between ingestion adherence, patch physiologic measures, and data from other telemetric devices. Enable collaboration with clinicians and caregivers.
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Tracking Adherence Enables Carers to Identify Patients Who Need Help
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ACCESSIBLE, SIMPLE BLOOD COLLECTION, ANYWHERE Virtually painless No big needles Simple to use Can be self-administered No cold chain required Ease of shipping Anywhere, Anytime Sampling
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Epigenetics – What is Known Tripartate Assay: Genetic, Blood (CBC), and Microbiome Genes predict probabilities not certainties Biomarkers of health not disease prediction Applications of single gene = single disease is very limited Genes work within complex genetic and environmental matrices Human base is @ 21,000 genes – DNA for protein coding is only 5% of this entire genome = “Dark Genome” Genes are turned on or oﬀ like a rheostat Genes change – What we do matters Majority of genes governed by beliefs and lifestyle choices Neanderthal genes are alive and well – Stress Responses
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Genes with No Direct Molecular Correlate in Blood Genes with Direct Molecular Correlates in Blood Genes with Direct Pathway/Network Correlates in Blood Genes with Clinical & Molecular Phenotype Correlates FOUR DISTINCT CLASSES Genes - CBC
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