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Epigenetics PowerPoint Presentation

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Description : This medical presentation on "Epigenetics" was delivered during Global Wellness Summit. The presentation talks about the Epigenetics Era, genetics, Single Nucleotide Polymorphisms: Common Genetic Variants, SNPs, DNA etc.

Tags : wellness, healthcare, Epigenetics Era, genetics, Single Nucleotide Polymorphisms, Common Genetic Variants, SNPs, DNA

Published on : Jul 19, 2020 | Views : 3961 | Downloads : 6

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Epigenetics Era Health Biomarkers vs Disease Prediction Genomics Study of the entire genome (Sequencing, Mapping & Interactions) Epigenomics Study of post-translational genetics modifications Metabolomics (Genetic Expression) Study of the complete set of metabolites or small molecules (Metabolic Intermediates, Byproducts, Hormones, Signaling Compounds) present in a cell or organism Microbiome: Study of all the microbes in and on a person
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Epigenetics: A Tripartite Assay = = =
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Single Nucleotide Polymorphisms: Common Genetic Variants SNPs SNPs act as a rheostat to express or suppress genetic predisposition Genetic Variation: central to personalized medicine SNPs influence by diet/nutrition, stress/meditation, radiation, physical and psychosocial. environment, Rxs, and sense of purpose >3 million SNPs identified Estimated potential 10+ million SNPs in the human genome SNPedia: 83,452 reference SNPs
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A Tripartite Assay Pilot Study Stool Microbiome, Pathogens, and Infectious Agents Among Olympic, Elite Athletes, and Extremely Healthy Adults DESIGN and PURPOSE: Olympic athletes, non-Olympic elite athletes, and other extremely healthy adults may have genetic and metabolic profiles that are unique. These profiles may contribute to the caliber of their performance, and they may provide keys to understanding select genetic and metabolic conditions. For further details contact: Dan McEvoy, President – Thorne/WellnessFX dmcevoy@thorne.com (917) 859-2505
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What Do We Test? Whole genome base mapping using next generation sequencing technology SNP based and whole gene based analytics Genetics More than 100 key blood biomarkers covering all key health and wellness problems Blood Genome sequencing based microbiome and metabolomics analysis for up to 300 key biomarkers Microbiome
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Genetic biomarker selection criteria: Gene biomarkers are stable from one time of testing to the next by the same laboratory. Genes are stable unless there is a specific intervention that alters them; Changes can be made in the expression of these genes by actionable, modifiable, self care lifestyle interventions; Changes can be detected in a maximum time frame of 10-12 weeks although many change in a matter of hours or days; and Are commercially available. EPIGENESIS Research Project
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EPIGENESIS: 7 Pillars of Optimal Health
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Inﬂamat ion Moderat e IBD High Lact ose Int olerance Glut on Int olerance Low Low There are cert ain known microbial signat ures t hat are closely associat ed with a number of condit ions. Ut iriure t incidunt consect et uer tation macto immitto praemit to ludus venio. Lupt at um minim aut em lobortis vindico fat ua aut em epulae. Dolore parat us olim plaga dolore duis aliquip demoveo import unus import unus defui meus. Ratis roto ad neque wisi ut opto. Phyla Level Relative Abundance & Diversity Ut iriure t incidunt consect et uer tation macto immitto praemit to ludus venio. Lupt at um minim aut em lobortis vindico fat ua aut em epulae. Dolore parat us olim plaga dolore duis aliquip demoveo import unus import unus defui meus. Ratis roto ad neque wisi ut opto. Relat ive Abundance Diversit y Important Genus & Species Diversity Genus Bact eroides Normal Ruminococcaceae Ruminococcaceae Gene GC,rs 2282679 Gene GC,rs 2282679 Folate Folate RBC Magnesium RBC Magnesium Vitamin D Vitamin D Example Phenotype Signature Your Signature Enterobacteriaceae Enterobacteriaceae alpha diversity HbA1c alpha diversity HbA1c Hypot het ical Example Factors Score Signature Map Your data compared to Healthy/ Baseline Factors 21 % down 11 % up 5 % down Insignificant Difference Insignificant Difference 15 % down 25 % down Enterobacteriaceae HBA1c Ruminococcaceae Gene GC, rs 2282679 Folate RBC Magnesium Alpha Diversity Summary Your Data Important Factors for this Phenotype Type 2 Diabetes Enterobacteriaceae HbA1c Ruminococcacea e Gene GC, rs2282679 presence 2 hours Oral intake Blood Glucose PPAR-R Vitamin D Fasting Blood Glucose Microbiome Genetics Blood DATA ANALYTICS: GENETICS, BLOOD, AND MICROBIOME
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THE MICROBIOME: KEY TO LIFE There are about one trillion bacteria living in the GI tract, ten times higher than the total amount of cells composing the human body. GI tract Reproductive tract Skin Eyes Ears
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System Summary Foundation 1 Ingestion Sensor Foundation 2 Wearable Sensor Foundation 3 Mobile Applications What it identifies That a specific pill, tablet or other ingested product (or combination) was ingested. Composed and powered entirely from materials found in the daily diet. What it senses Precise time & identity of ingestions. Certain physiologic responses and consumer behaviors over time. –HR, HRV, activity, sleep, temperature. Acts as communications hub between ingested product and phone. What it influences Consumer reported wellness metrics. Correlations between ingestion adherence, patch physiologic measures, and data from other telemetric devices. Enable collaboration with clinicians and caregivers.
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Tracking Adherence Enables Carers to Identify Patients Who Need Help
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ACCESSIBLE, SIMPLE BLOOD COLLECTION, ANYWHERE Virtually painless No big needles Simple to use Can be self-administered No cold chain required Ease of shipping Anywhere, Anytime Sampling
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Epigenetics – What is Known Tripartate Assay: Genetic, Blood (CBC), and Microbiome Genes predict probabilities not certainties Biomarkers of health not disease prediction Applications of single gene = single disease is very limited Genes work within complex genetic and environmental matrices Human base is @ 21,000 genes – DNA for protein coding is only 5% of this entire genome = “Dark Genome” Genes are turned on or off like a rheostat - Epigenetics Gene expression changes – What we do matters Majority of genes governed by beliefs and lifestyle choices Neanderthal genes are alive and well – Stress Responses
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Genes with No Direct Molecular Correlate in Blood Genes with Direct Molecular Correlates in Blood Genes with Direct Pathway/Network Correlates in Blood Genes with Clinical & Molecular Phenotype Correlates FOUR DISTINCT CLASSES Genes - CBC
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Personalized Nutrition Founded in 2015 by Neil Grimmer with over $32 Million in funding by Campbell’s Soup Based on DNA, fasting blood, a metabolic challenge, and a food behavioral assessment “Challenge Shake” is high fat, high protein, high dairy, and high sugar designed to “challenge” your body finger stick blood draws at baseline, 30 mins after drinking a “Challenge Shake”, and at 120 minutes Test results are converted into 7 recommended diets based on the bell curves generated in the course of your metabolism & a genetic assessment Ongoing R&D with EXOS, Blue Cross/Blue Shield, and a leading healthcare provider

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