Download Free Medical About Non Hodgkins lymphoma (NHL) PowerPoint Presentation

About Non Hodgkins lymphoma (NHL) PowerPoint Presentation

DOWNLOAD MEDICAL POWERPOINT PRESENTATION

About This Presentation

Description : This medical presentation on cancer titled "About Non Hodgkin’s lymphoma (NHL)" is about Non-Hodgkin’s lymphomas, a heterogeneous group of malignant lymphomas. The presentation also tells about different types NHL.

Tags : Cancer, Non-Hodgkin’s Lymphoma, NHL, heterogeneous, malignant lymphomas, subtypes, morphology, immunophenotype, molecular, cytogenetics, diagnosis, Treatment, indolent, aggressive

Published on : Apr 28, 2021 | Views : 2287 | Downloads : 17

Shareable Url :

Embed Code :

Comment

Transcript

Slide 1-

Non Hodgkin’s lymphoma Rakesh Biswas MD, Professor, Department of Medicine, People's College of Medical Sciences, Bhanpur, Bhopal, India
Slide 2-

ppt slide no 2 content not found
Slide 3-

ppt slide no 3 content not found
Slide 4-

ppt slide no 4 content not found
Slide 5-

Staging Stage I : Involvement of single LN region (I) or extra lymphatic site (IAE ) Stage II : Two or more LN regions involved (II) or an extra lymphatic site and lymph node regions on the same side of diaphragm Stage III : Involvement of lymph node regions on both sides of diaphragm, with (IIIE) or without (III) localized extra lymphatic involvement or involvement of the spleen (IIS) or both (IISE) Stage IV : Involvement outside LN areas (Liver, bone marrow) A : Absence of ‘B’ symptoms B : B symptoms present
Slide 6-

ppt slide no 6 content not found
Slide 7-

Non Hodgkin’s lymphoma Incidence is increasing NHL>HD Median age of presentation is 65-70 yrs M>F More often clinically disseminated at diagnosis B-cell-70% ; T-cell-30%
Slide 8-

Clinical features Widely disseminated at presentation Nodal involvement: Painless lymphadenopathy, often cervical region is the most common presentation Hepatospleenomegaly Extranodal : Intestinal lymphoma ( abdominal pain, anemia, dysphagia); CNS ( headache, cranial nerve palsies, spinal cord compression) ; Skin, Testis; Thyroid; Lung Bone marrow (low grade): Pancytopenia
Slide 9-

Clinical features contd Systemic symptoms Sweating, weight loss, itching Metabolic complications: hyperuricemia, hypercalcemia, renal failure Compression syndrome: Gut obstruction Ascites SVC obstruction S/C Compression
Slide 10-

Classification REAL Clinical / Working Formulation Low grade Intermediate grade High grade
Slide 11-

Classification Low grade Proliferation: Low Course: Indolent Symptoms: -ve Treatment: Not curable High grade High Rapid, fatal(un-Rx) +ve Potentially Curable
Slide 12-

Etiology Cannot be attributed a single cause Chromosomal translocations: t (14, 18) Infection: Virus:EBV, HTLV,HHV-8, HIV Bacteria: H.Pylori - Gastric lymphoma Immunology: Congenital immunodeficiency, Immunocompromised patients - HIV, organ transplantation
Slide 13-

Management Low grade: Asymptomatic : No treatment ; Radiotherapy for localised disease (Stage 1); Chemotherapy: mainstay is Chlorambucil; Initial response good , but repeated relapses, median survival 6-10 yrs; Newer: Fludarabine, 2-CdA (Chlorodeoxyadenosine) Monoclonal antibody: Rituximab SCT/BMT
Slide 14-

Aggressive ( high / intermediate grade): Chemotherapy: mainstay CHOP -every 3 weeks, at least 6 cycles Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine, Prednisolone
Slide 15-

High risk cases with poor prognostic factors or relapse : High dose chemotherapy combined with autologous BMT / SCT Monoclonal antibody With CNS involvement / leukemic relapse : Similar to ALL
Slide 16-

Prognosis Low grade : Median survival –10 yrs High Grade: Increasing age, advanced stage, concomitant disease, raised LDH,T- cell phenotype : Poor prognosis