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Description : Prematurity, prenatal development, and substance exposure. Zika virus (ZIKV) is an emerging mosquito-transmitted flavivirus that can cause severe disease, including congenital birth defects during pregnancy.

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Prematurity, prenatal development, and substance exposure Daniel Messinger, PhD
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Messinger Class Define prematurity. What factors predict the survival of premature infants How can prematurity be treated? What factors affect disability in the survivors? What types of disability and other outcomes are likely in survivors? How are mortality and morbidity rates of premature infants changing? If a baby is born 8 weeks premature, how long after birth would you conduct a 52 week assessment, after correcting for prematurity? How do socioeconomic status (maternal education) and prematurity to influence developmental outcome? What is the impact of variables such as maternal sensitivity on outcome – on which infants do they have the greatest impact? What interventions might improve the outcomes of premature infants (Kangaroo care, other types of physical contact) – please describe. How do you think public health policy should be structured to prevent negative developmental outcomes? What are the Fetal Origins of Adult Disease?
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Messinger Infant mortality rate (Ascending) The rate in the United States is 5.98, and there are 48 countries with lower rates, although many of those use a less stringent definition of mortality than the US http://en.wikipedia.org/wiki/List_of_countries_by_infant_mortality_rate
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Zika virus (ZIKV) is an emerging mosquito-transmitted flavivirus that can cause severe disease, including congenital birth defects during pregnancy1 http://www.cdc.gov/zika/?s_cid=OADC-Zika-Miami-search-google-ga-001 https://en.wikipedia.org/wiki/Zika_virus Messinger
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mAb treatment markedly reduced tissue pathology, placental and fetal infection, and mortality in mice isolated human monoclonal antibodies (mAbs) in subjects with prior ZIKV subset of mAbs recognized diverse epitopes on the envelope (E) protein and exhibited neutralizing activity. mAbs ZIKV-117, broadly neutralized infection of ZIKV strains…. Neutralizing human mAbs can protect against maternal–fetal transmission, infection, disease. Messinger
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Messinger Infant mortality The rate in the United States is 5.98, and there are 48 countries with lower rates, although many of those use a less stringent definition of mortality than the US http://en.wikipedia.org/wiki/List_of_countries_by_infant_mortality_rate
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Messinger Mortality rate decreasing
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Messinger Predicting prematurity Definition: 37 weeks gestational age or less Associated with low birthweight, > 2,500 g Incidence is linked to social risk and ethnicity socioeconomic status Ethnicity Norway 3 per 1,000 Caucasian American 5.5 per 1,000 African American 13.5 per 1,000
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Messinger Premature infants differ in degree of prematurity, in related medical problems, and social risks
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Messinger More premature - reduced survival (survival rates increase over historical time) Weeks Gestation Survival 21 weeks 0% 22 weeks 0-10%* 23 weeks 10-35% 24 weeks 40-70% 25 weeks 50-80% 26 weeks 80-90% 27 weeks >90% 30 weeks >95% 34 weeks >98% A baby's chances for survival increases 3-4% per day between 23 and 24 weeks of gestation and about 2-3% per day between 24 and 26 weeks of gestation. After 26 weeks the rate of survival increases at a much slower rate because survival is high already. http://www2.medsch.wisc.edu/childrenshosp/parents_of_preemies/toc.html
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Messinger
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Messinger Survival The most important predictors greater gestational age heavier birth weight absence of severe breathing problems, congenital abnormalities, and other diseases like infections
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Messinger At a given age/weight Male infants are slightly less mature and have a slightly higher risk of dying than female infants. African-American babies have a slightly better survival than Caucasian most other groups are intermediate between the two
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Messinger Significant disability Moderate or severe mental retardation, inability to walk without assistance, blindness or deafness More extreme prematurity is associated with greater risk of these conditions. At 23-24 weeks of gestation, risk is about 50%. As gestational age increases, the risk of significant disability declines dramatically.
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Messinger More developmental problems as birth weight decreases ELBW infants more mild (<85) to significant (<70) delays on Mental (MDI) & Psychomotor Scales (PDI) of Bayley (BSID-II) 66% and 57% of ELBW children below normative range on MDI and PDI,, 18 - 22 months corrected age Shankaran, 2004; 5 Vohr, B.R. 2000; 6 Vohr, B.R. 2005; 3 Walsh, M.C. 2005 Poor performance on these measures may reflect early deficits in behavior regulation among ELBW infants including difficulty adapting to change, difficulty sustaining attention, increased activity level, increased need for examiner support and less persistence in attempting to complete tasks Anderson, P. 2003; 27 Leonard, C.H. 2001; 9 Saigal, S. 2001; 19 Sajaniemi, N. 2001; 26 Weiss, S.J. 2004; 10 Whitfield, M.F. 1997
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Messinger ELBW infants at risk at 18 months 25% had an abnormal neurologic exam; 37% had a Bayley II Mental MDI <70; 29% had a Psychomotor PDI <70, 9% had vision & 11% had hearing impairment Increased morbidity: decreasing birth weight; lung disease; IVH 3-4 (brain hemorrhage), necrotizing enterocolitis Decreased morbidity: female gender, higher maternal education, and white race. Vohr, B. R. et al., (2000). Neurodevelopmental and Functional Outcomes of Extremely Low Birth Weight Infants in the National Institute of Child Health and Human Development Neonatal Research Network, 1993-1994. Pediatrics, 105(6), 1216-1226.
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Messinger Big picture Continuous advances in medical technology mean that younger and lighter babies can be saved Does this mean an increase in the proportion of surviving infants who have disabilities?
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Messinger Survival improving—illness constant? Survival in infants 501-1500 g improved, 84% (1995-1996), 80% in 1991, 74% in 1988. Increased survival not associated with increased major morbidities 1991-1996 CLD (chronic lung disease; 23%), proven NEC (7%), and severe ICH (11%)—did not change Mortality & major morbidity remain high for smallest: <600 g at birth. Lemons, J. A., Bauer, C. R., et al. & Network, N. N. R. (2001). Very Low Birth Weight Outcomes of the National Institute of Child Health and Human Development Neonatal Research Network [14 participating centers], January 1995 Through December 1996. PEDIATRICS, 107(1), e1.
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Messinger, Lambert, Bauer et al., 2010 Behavior predicts cognitive/motor development in ELBW children. 18 month Behavior Record Scale (BRS) 30 month MDI and PDI Controlling for gender, birth weight, maternal income, maternal education, 18-month MDI and 18 month PDI, In identical models, 18 month BRS Motor Quality predicted both 30-month MDI and 30-month PDI.
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Messinger What’s corrected age? If baby born 10 weeks early 52 weeks after birth comes 10 weeks early Only 30 weeks gestation Not 40 weeks So its 82 – not 92 – weeks of development after conception Solution: Correct (wait) 10 weeks Gives premies a chance to get on course Correct until 2 or 3 years
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Messinger Predictors of disability Identifiable brain abnormalities such as more severe intraventricular hemorrhages (IVH) may occur before birth or in the nursery Babies who have been the sickest and/or remained sick for long periods of time (several weeks).
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Messinger Mortality and disability Among premature (low birth weight) babies mortality and disability survival and normal development may be predicted by different factors Messinger, D., Dolcourt, J., King, J., Bodnar, A., & Beck, D. (1996). The survival and developmental outcome of extremely low birthweight infants. Infant Mental Health Journal, 17(4), 375-385.
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Messinger Mortality predicted by Lower birthweight Five minute Apgar < 3 Infant viability at 5 minutes No administration of surfactant A common treatment for lung immaturity These factors predict mortality correctly for 78% of the babies But if a baby makes it, they do not predict disability . . .
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Messinger Disability Lower Bayley scores (worse cognitive functioning) and cerebral palsy predicted by brain abnormalities specifically more severe brain bleeds grade III or IV intraventricular hemorrhage Messinger, D., Dolcourt, J., King, J., Bodnar, A., & Beck, D. (1996). The survival and developmental outcome of extremely low birthweight infants. Infant Mental Health Journal, 17(4), 375-385.
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Messinger Prematurity in context Prematurity is a biological risk factor but outcome is also associated with social risk factors
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The effects of biological and social risk factors on special education placement: Birth weight and maternal education as an example Hollomon, H.A. Dobbins, D. R., & Skott, K.G. (1998). Research in Developmental Disabilities, 19(3), 281-294.
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Messinger Background Children born LBW are at an increased risk for placements in special education. Between 30% to 60% of LBW children receive some remedial academic services. Even after controlling for socioeconomic status, maternal education, and intelligence, LBW children are placed in special education more often than their normal birthweight peers.
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Messinger Special education placements Low birthweight infants are typically at risk for Learning disability Speech impaired Emotionally handicapped Mentally handicapped Educable, trainable, severely Physical Impairment
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Messinger Risk of special education placement As birthweight decreases, the risk for special education placement increases. Low maternal education also increases the risk of special education placement
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Messinger Minor disabilities Often not recognized until school age: e.g., short attention span; specific learning problems; poorer than average coordination; needing glasses at an early age. Occur in approximately half of infants weighing less than 3 1/2 pounds at birth. Children with minor disabilities usually lead normal lives. Early identification of these problems helps make learning easier.
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Messinger Relative risk of special education by mom education & baby birth weight Individual Risk
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Messinger Policy: What’s the biggest population risk?
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Messinger Public policy: Target Low Maternal Education Low Maternal Education associated with almost one fifth of the children in special education & highest percentage of special education placements. ~One third of children born to mothers with less than 12 years of education. 22% of the sample had mothers with LME in the Metropolitan Atlanta Developmental Disabilities Study (Satcher, 1995). Less than 1% of children receiving special education services can be attributed to being VLBW because it is a low prevalence condition. Agree or disagree?
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Messinger How prevalent is low birth weight? The linked sample (total N = 27,951): children born in FL in 1979/80 and in FL public schools during the 1992/93. 500-999g 1000-1499g 1500-1999g 2000-2500g 2500g or greater n = 188 n = 902 n = 2,349 n = 8,396 n = 158,431
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Messinger Relative risk of special education by mom education & baby birth weight
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Messinger Conclusions Birthweight Maternal education great dichotomous predictor Interaction: Impact of low birthweight greater when mother does not have high school diploma How does maternal education influence baby?
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Theoretical Framework Social Interaction Quality -Preterm infants showed limited amount and poorer quality of Interactions with parents Infant factors Gestational age Birth weight Physiological regulation (HRV) Romero Maternal factors -Less interactive -SES -Feeding route
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Poehlmann et al Study Study Design 5 timepoints NICU, 4 months, 9 months, 16 months, 24 months Sample 120 infants and their mothers Infants ≤ 35 weeks gestation or < 2500 grams at birth No congenital or neurological problems Infants were from 3 NICU centers in southeastern Wisconsin 2002-2005 Variables and Measures Romero
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Positive affect, Social/Communicative Competence at 4 Months Higher vagal regulation  less positive affect & communication at 4 months but greater increases over time exceed those infants with lower vagal regulation. Fewer SES risks more optimal interactions at 4 months. More neonatal health risks showed more positive affect at 4 months. Quality of Play, Interest, and Attention: Higher in infants born closer to term. Lower in infants with more SES risks Dysregulation and Irritability: Higher vagal regulation implied less dysregulation and irritability. Romero
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Messinger
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HRV & SESAffect/communic Messinger
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Interventions for the premature infant: Kangaroo Care (KC) ‘Holding a diaper-clad infant in skin-to-skin contact, prone and upright on the chest of the parent. Subsequent text from http://www.adhb.govt.nz/newborn/guidelines/developmental/KangarooCare.htm Initiated after acute risk has passed Developing and developed world? http://www.youtube.com/watch?v=gQwdlMnkhbA&feature=related http://www.youtube.com/watch?v=5yl-prEacIM&feature=related daddy Wrap Instructions: Kangaroo Care with a Wrap Messinger
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Administer Kangaroo Care to medically stable infants Messinger Exclusion Criteria First 5 days for infants less than 30 weeks gestation… Unstable on respiratory support (CPAP or ventilation) After major procedures or treatment e.g extubation
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Reported Benefits of Kangaroo Care Decreased variation in heart/respiratory rates, improved oxygenation, less bradycardia… Maintains skin and core temperatures through conduction of heat from the parent. Promotes optimal growth and development. Beneficial for sleep-wake organization. Increases milk production and access to breast. Messinger
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Sample study Reduction hypothermia (10/44 vs 21/45) higher oxygen saturations (95.7 vs 94.8) decrease in respiratory rates (36.2 vs 40.7) No differences in hyperthermia, sepsis, apnea, onset of breastfeeding and hospital stay in two groups. Randomized controlled trial was performed over one year: kangaroo mother care (KMC) vs. conventional 1: Indian J Pediatr. 2005 Jan;72(1):35-8. Feasibility of kangaroo mother care in Mumbai.Kadam S, Binoy S, Kanbur W, Mondkar JA, Fernandez A. Messinger
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Family involvement, massage therapy “Massage therapy has been notably effective in preventing prematurity, enhancing growth of infants, increasing attentiveness, decreasing depression and aggression, alleviating motor problems, reducing pain, and enhancing immune function. “ Massage therapy research.Field, Tiffany; Diego, Miguel; Hernandez-Reif, Maria. Developmental Review. Vol 27(1), Mar 2007, 75-89. Messinger
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Messinger Sensitive parenting helps children at highest medical risk Parenting (6 & 12 months) sensitive to infant focus of interest and not highly controlling  Greater increases & faster rates of cognitive-language & social development @ 6, 12, 24, 40 mos. Relations stronger for high risk (HR; n = 73) Vs. full-term n=112 & medically low risk but low birth weight, n=114 Sensitive behaviors may support HR children learning despite early attentional and organizational problems. Landry, S. H., Smith, K. E., Miller-Loncar, C. L., & Swank, P. R. (1997). Predicting cognitive-language and social growth curves from early maternal behaviors in children at varying degrees of biological risk. Developmental Psychology, 33(6), 1040-1053. Confounds?
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Messinger Mom maintaining vs. restrictiveness Landry et al., 1997
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Messinger For both LBW & NBW ‘Mothers' maintaining children's interests supported 2- & 3½-yr skills 4½-yr cognitive and social independence Directiveness supported children's early cognitive and responsiveness skills but by 3½ yrs, high levels of this behavior had a negative influence on cognitive and social independence at 4½ yrs. High levels of maintaining interests across these ages support later independence, but directiveness needs to decrease in relation to children's increasing competencies.’ Landry, S. H., Smith, K. E., Swank, P. R., & Miller-Loncar, C. L. (2000). Early maternal and child influences on children's later independent cognitive and social functioning. Child Development, 71, 358-375.
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Responsive Parenting: Establishing Early Foundations for Social, Communication, and Independent Problem-Solving Skills (Landry, Swift, & Swank, 2006) Responsive parenting: Contingent responding Emotional-affective support Support for infant foci of attention Language input that supports developmental needs Intervention: PALS (Playing and Learning Strategies) v. DAS (Developmental Assessment Screening) 263 infants, 10 home visits between 6-10 months of age Mothers reviewed weekly experience, visitor described purpose of visit, discussed educational videotapes, videotaped mothers, mothers critiqued own behavior, discussed responsive strategies Infants were videotaped and assessed at each visit Nayfeld
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Influence of responsive parenting on infant behavior: Intervention Increases in mother’s responsive behaviorsincrease in infant skills in first year Responsiveness in all aspects improved more in target mothers Greater changes in infant behaviors (cooperation, use of words, affect, problem solving) in PALS Both with mother and novel adult Responsiveness mediates impact on infant development General responsiveness construct, with 4 distinct factors Contingent responsiveness, verbal encouragement, and restrictiveness are mediators Fully mediated relationship intervention became non-significant Nayfeld
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Messinger Catch-up facilitated by more optimal social environment Brain plasticity Median PPVT-R increased from 88 (36 months) to 99 at (96 months) in 296 VLBW infants (600 to 1250 g) 45% of children gained 10 points or more Increasing age, 2-parent household, higher levels of maternal education all associated with higher scores children with early-onset IVH and subsequent CNS injury had lowest initial scores & the scores declined over time (interaction). Change in cognitive function over time in very low-birth-weight [VLBW] infants (Ment et al, 2003, JAMA, 289, 705-71
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Long-term: Educational disadvantage but lower risk-taking 242 very-low-birth-weight (VLBW) infants (born ‘77-79 at 1179 g) vs 233 normal birth weight 74% vs 83% VLBW adults graduate hi school: VLBW men, but not women, significantly less likely than controls to be in postsecondary study (30% vs. 53%, P=0.002). VLBW lower IQ (87 vs 92) & academic achievement (10% vs. <1%) neurosensory impairments and subnormal height (10% vs. 5%, P=0.04). VLBW report less alcohol & drug use & lower pregnancy differences in those without neurosensory impairment? Hack, M., Flannery, D. J., Schluchter, M., Cartar, L., Borawski, E., & Klein, N. (2002). Outcomes in Young Adulthood for VLBW Infants. New England Journal of Medicine, 346(3), 149-157. Messinger Why?
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Messinger Lower risk-taking…Why? Details from Hack, M., Flannery, D. J., Schluchter, M., Cartar, L., Borawski, E., & Klein, N. (2002). Outcomes in Young Adulthood for VLBW Infants. New England Journal of Medicine, 346(3), 149-157.
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The fetal origins of adult disease “…the 20th century epidemic of coronary heart disease in Western countries might have originated in fetal life…. The epidemic coincided with improved standards of living and nutrition, yet …its greatest impact was in the most deprived areas… early in the 20th century these areas had the highest rates of neonatal mortality and by inference the highest rates of low birth weight... impaired fetal growth might have predisposed the survivors to heart disease in later life.” BMJ 2001;322:375-376 ( 17 February ) Messinger
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Fetal Origins of Adult Disease: Concepts and Controversies Association of low birthweight with increased risk of coronary heart disease, stroke, and type 2 diabetes. controlling for lifestyle factors such as smoking, physical activity, occupation, income, dietary habits, and childhood socioeconomic status. NeoReviews Vol.5 No.12 2004 e511 © 2004 American Academy of Pediatrics. Rebecca Simmons* Infants compensating for earlier weight loss in a way that does not bode well long-term Messinger
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Mechanism of effects? Combination of small size at birth and during infancy, followed by accelerated weight gain from age 3 to 11 years, predicts large differences in CHD, type 2 diabetes and hypertension. Mechanisms: developmental plasticity and compensatory growth. Int J Epidemiol. 2002 Dec;31(6):1235-9. Links. Fetal origins of adult disease: strength of effects and biological basis. Barker DJ, Eriksson JG, Forsén T, Osmond C. Messinger
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Prenatal acoustic communication programs offspring for high posthatching temperatures in a songbird by Mylene M. Mariette, and Katherine L. Buchanan Science Volume 353(6301):812-814 August 19, 2016 Published by AAAS
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Fig. 1 Incubation calling behavior in relation to incubation stage and ambient temperatures. Mylene M. Mariette, and Katherine L. Buchanan Science 2016;353:812-814 Published by AAAS
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Fig. 2 Nestling mass on day 13 (i.e., at the end of the nestling phase) in relation to nest temperature above ambient. Mylene M. Mariette, and Katherine L. Buchanan Science 2016;353:812-814 Published by AAAS
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Fig. 3 Probability of calling while begging in relation to nest temperature experienced since hatching (nest temperature above ambient + mean daily maximum temperature) for nestlings that heard incubation calls (green) or control calls (blue) as embryos. Mylene M. Mariette, and Katherine L. Buchanan Science 2016;353:812-814 Published by AAAS
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Fig. 4 Effect of incubation calling as late-stage embryos on individuals’ reproductive success and thermal preferences in their first year. Mylene M. Mariette, and Katherine L. Buchanan Science 2016;353:812-814 Published by AAAS
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Messinger Additional readings Messinger, D., Dolcourt, J., King, J., Bodnar, A., & Beck, D. (1996). The survival and developmental outcome of extremely low birthweight infants. Infant Mental Health Journal, 17(4), 375-385. Hollomon, H.A. Dobbins, D. R., & Skott, K.G. (1998). The effects of biological and social risk factors on special education placement: Birth weight and maternal education as an example. Research in Developmental Disabilities, 19(3), 281-294. Infant Health and Development Project (1990). Enhancing the outcomes of low-birth-weight, premature infants: A multisite, randomized trial. Journal of the American Medical Association, 263(22), 3035-3042. Brooks-Gunn, J., McCarton, C., McCormick, M. C., & Klebanov, P. K. (1998). The contribution of neighborhood and family income to developmental test scores over the first three years of life. Child Development, 69(5), 1420-1436. Vohr, B. R., Wright, L. L., Dusick, A. M., Mele, L., Verter, J., Steichen, J. J., Simon, N. P., Wilson, D. C., Broyles, S., Bauer, C. R., Delaney-Black, V., Yolton, K. A., Fleisher, B. E., Papile, L.-A., & Kaplan, M. D. (2000). Neurodevelopmental and Functional Outcomes of Extremely Low Birth Weight Infants in the National Institute of Child Health and Human Development Neonatal Research Network, 1993-1994. Pediatrics, 105(6), 1216-1226. Susan Landry, Developmental Psychology. Zeanah, C. on developmental risk. J am acad child and adol psychiatry '97 362.
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Messinger Change in cognitive function over time in very low-birth-weight [VLBW] infants (Ment et al, 2003, JAMA, 289, 705-711)