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Pediatric oncology and hematology PowerPoint Presentation

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Description : Check out this medical PowerPoint presentation titled "Pediatric oncology and hematology”.

This medical PowerPoint presentation is about pediatric oncology and hematology, a medical specialty that focuses on the diagnosis, treatment, and management of cancer and blood disorders in children and adolescents. Pediatric oncologists and hematologists are medical doctors who have received specialized training in the care of children and teens with cancer and blood disorders.

Pediatric oncology involves the treatment of various types of childhood cancers such as leukemia, lymphoma, brain tumors, bone tumors, and sarcomas. The treatment options for pediatric cancers often involve a combination of chemotherapy, radiation therapy, surgery, and immunotherapy.

Pediatric hematology involves the diagnosis and treatment of blood disorders such as sickle cell disease, thalassemia, hemophilia, and various types of anemia. Treatment options for these conditions may include blood transfusions, medications, and bone marrow transplantation.

The care of children with cancer and blood disorders often requires a multidisciplinary approach, involving a team of healthcare professionals such as pediatric oncologists, pediatric hematologists, nurses, social workers, psychologists, and other specialists. This approach helps to ensure that children receive comprehensive care and support throughout their treatment and recovery.

Pediatric oncology and hematology has made significant progress in recent years, resulting in improved outcomes for children with cancer and blood disorders. Advances in technology and research have led to the development of new treatment options and therapies, giving hope to many families affected by these conditions.

Tags : Pediatric oncology and hematology, blood disorders in children and adolescents, Hematology, Hematology PowerPoint presentation

Published on : May 29, 2023 | Views : 1008 | Downloads : 1

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Slide 1-

Programme 1. Hematological malignancies: acute leukemias, lymphomas 2. Solid tumors, part I: Brain tumors, neuroblastoma, Wilms tumor, hepatoblastoma, germ cell tumors 3. Solid tumors, part II: soft tissue sarcomas, osteosarcoma, Ewing sarcoma, late effects after anticancer treatment 4. Anaemias 5. Coagulation disorders
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Pediatric oncology and hematology Hematological malignancies: Acute lymphoblastic leukemia Acute non-lymphoblastic (myeloblastic) leukemia Non-Hodgkin lymphoma Hodgkin lymphoma
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Childhood leukemia
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Uncontrolled proliferation of immature blood cells with a different immunological subtypes which is lethal within 1 –6 months without treatment The disorder starts in the bone marrow, where normal blood cells are replaced by leukemic cells Morphological (FAB), immunological, cytogenetic, biochemical, and molecular genetic factors characterize the subtypes with various response to treatment
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Incidence Most frequent neoplasm in children (28 – 33%) 45/ 1million children under the age of 16 years Incidence peak at 2 – 5 years 75-80%- acute lymphoblastic leukemia -ALL 15-20% - acute myelogenous (non-lymphoblastic) leukemia AML/ ANLL <5% - undifferentiated acute leukemia and chronic myelogenous leukemia -CML
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Ethiology Unknown Higher risk in congenital disorders: -trisomy 21 (14 times higher) and other trisomies -Turner syndrome -Klinefelter syndrome -monosomy 7 -neurofibromatosis type 1 -Fanconi anemia (high fragility of chromosomes) -Bloom syndrome, Kostmann S., Shwachman-Diamond S., -ataxia- teleangiectasia -congenital agammaglobulinemia -Wiskott- Aldrich S.
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Ionizing radiation (atomic bomb developed high incidence of leukemia) Chemical and drugs: -benzene -chloramphenicol -alkylating agents Infection (viral –HTLV, EBV, HIV) Immunodeficiency: agamma/hypogammaglobulinemia, Wiskott-Aldrich S, HIV infection
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Acute lymphoblastic leukemia 80% of leukemias Girl – to- boy ratio is 1: 1.2 Peak incidence 2 – 5 years Incidence in white children is twice as high as in nonwhite children
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Clinical manifestation General aspects: - history and symptoms reflect: the degree of bone marrow infiltration by leukemic cells and the extramedullary involvement of the disease - the duration of symptoms is days to several weeks, occasionally – several months - often: low –grade fever, signs of infection, fatigue, bleeding, pallor
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The symptoms depend on the degree of cytopenia: - anemia: pallor, fatigue, tachycardia, dyspnea, occasionally- cardiovascular decompensation - leukopenia:infections, temperature elevation - thrombocytopenia: petechiae, mucosal bleeding, epistaxes, prolonged menstrual bleeding
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Specific signs and symptoms Eye: bleeding, infiltration of local vessels,
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CNS: at time of diagnosis less than 5% have CNS leukemia with meningeal signs (morning headache, vomiting, papilla edema, focal neurological signs)
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Laboratory: Lk 3,91 Er 2,91 Hb 9,2 Ht 25,1 Blood smear: neutr-9% ly- 45% bl-46% LDH 976 Ear, nose, throat: -lymph nodes infiltration (isolated or multiple) -Mikulicz syndrome (infiltration of salivary glands and/or tear glands)
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Skin: maculopapular skin infiltration, often of deep red color (infants)
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Cardiac involvement: -leukemic infiltration or hemorrhage -occasionally cardiac tamponade due to pericardial infiltration -tachycardia, low blood pressure or other signs of cardiac insufficiency Mediastinum: -enlargement due to leukemic infiltration by lymph nodes and /or thymus (observed in T-cell leukemia) Pleura/and pericardium: effusion Kidney enlargement
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Lymphadenopathy Gastrointestinal involvement: -hepato- and/or splenomegaly
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Testicular involvement: enlargement of one or both testes without pain , hard consistency Penis: priapism is occasionally associated with elevated WBC Bone and joint involvement: -bone pain initially present in 25 % to 50% of patients ! -bone or joint pain, sometimes with swelling and tenderness due to leukemic infiltration of the periosteum. Differential diagnosis: rheumatic fever, rheumatoid arthritis -radiological changes: diffuse demineralization, osteolysis,
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Laboratory findings Red cells: -hemoglobin – normal/ moderate /markedly low -low number of reticulocytes White blood cell : - normal/ low/ high -in children with high WBC- leukemic blast cells present Platelets: -usually low
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Coagulopathy: -in children with hyperleukocytosis -more common in AML -low levels of prothrombin, fibrinogen, factors V, IX, and X may be present Chemistry: -the serum uric acid is often high initially - the serum potassium level may be high (cell lysis) -serum hypocalcemia or hypercalcemia (in marked leukemic bone infiltration) abnormal liver function > increased level of transaminases
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Bone marrow analysis: >25% blasts -characterize the blast cells -determine the degree of reduction of normal hematopoiesis -morphological, immunological, biochemical, and cytogenetic analyses Differential diagnosis: aplastic anemia, myelodysplastic syndrome, neoplastic infiltrations (neuroblastoma, NHL)
Slide 22-

Leukemic cell characterization and classification: Morphology: FAB classification: ALL - L1, ALL-L2, ALL-L3 AML M0 – M7 chemistry: ALL: + periodic acid Schiff(PAS) AML: + Sudan black, + peroxidase
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Immunological characterization: -monoclonal antibodies to leukemia-associated antigens differentiate between types of leukemic cells: * lympoid stem cells: CD19, HLA-DR, CD 24 (+/-) * early pre-B cells: CD19, HLA-DR, CD24 * pre-B cells: CD19, HLA-DR, CD24, CD10, CD20(+/-) * B-precursors cell: CD19, HLA-DR, CD24, CD10, CD20 * T-cell lineage: CD7, CD2, CD1, CD4, CD8,CD3
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Cytogenetic characterization: - in 85% of children abnormal karyotype in the malignant clone *t(9;22) (BCR-ABL) –unfavorable prognosis *t (4;11) in infants , poor prognosis -ploidy and structure of chromosomes (rearrangements) -hypoploidy- poor prognosis -DNA index (DI)
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Prognostic factors Favorable: WBC <10x10 9/l Age 2-7 Female Response on steroid (+) Pre-B-ALL Hyperploid FAB L1 ↑LDH moderate Unfavorable: WBC >50 x 10 9/L Age < 2 and >10 Male Response on treatment (-) Hypoploid, t(9;22)/t(9;11) FAB L2/L3 ↑↑LDH high visceromegaly
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Differential diagnosis Leukemic reaction in bacterial infection, acute hemolysis,tuberculosis, sarcoidosis, histoplasmosis Lymphocytosis: pertussis Infectious mononucleosis Aplastic anemia Idiopathic thrombocytopenia Bone marrow infiltration by a solid tumor (NBL,NHL, RMS) Rheumatoid arthritis, rheumatoid fever
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Therapy In experienced center Subdivided into: -remission induction -consolidation with CNS prophylaxis -maintenance phase Prognosis Rate of first remission in ALL: more than 90% 80% of children survive without relapse
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Response on treatment Reaction on steroids (7.day) Reaction on chemotherapy (15. and 33. day) Minimal residual disease - MRD (-)
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Acute myelogenous leukemia Heterogeneous group of malignant hematological precursor cells of the myeloid, monocytic, erythroid or megakaryocytic cell lineage Epidemiology: 15-20% of all leukemias in children Frequency remains stable throughout childhood with slight increase during adolescence No difference in incidence between boys and girls
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FAB classification M0: immature myeloblastic leukemia M1: myeloblastic leukemia M2: myeloblastic leukemia with signs of maturation M3: promyelocytic leukemia M4: myelomonocytic leukemia M5: monocytic leukemia M6: erythroleukemia M7: megakaryocytic leukemia
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Cytogenetics
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Prognostic factors
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Clinical presentation Bleeding: thrombocytopenia + coagulopathy (DIC) Leukostasis in the lungs or CNS Tumor lysis syndrome Granulocytic sarcoma (chloroma) Infection (fungal, opportunistic)
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Therapy Induction/ consolidation/ intensification/ maintenance - in AML3 + ATRA Allogeneic/ autologous stem cell transplantation Prognosis 5+year survival rate 50-60 %
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Non-Hodgkin lymphoma (NHL)
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Neoplasia of the lymphatic system and its precursor cells with genetically disturbed regulation, differentiation and apoptosis If marked bone marrow involvement is present the clinical condition is equal of leukemia Incidence 5 –7 % of all neoplasias in childhood Peak incidence between 5 and 15 years Ratio of boys to girls 2:1 Burkitt lymphoma (BL): endemic form in Africa 10:100,000 children and sporadic form in Europe and USA
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Etiology, pathogenesis and molecular genetics Often chromosomal alterations are detecable: in B-cell NHL translocation of chromosome 14 - t(18;14) Predisposing factors for NHL: Acquired immunodeficiency: autoimmune disorders, HIV infection EBV infection Congenital B-cell defect, congenital T-cell defect with thymus hyperplasia Bloom syndrome, Chedak-Higashi syndrome, SCID, ataxia teleangiectasia, Wiskott-Aldrich syndrome Exposure to irradiation Drug induced, after immunosuppressive treatment
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WHO classification
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Burkitt lymphomaBurkit-like lymphoma About 50% of NHL Localization: abdomen, lymphatic tissue of adenoids and tonsils 80% with translocation t(8;14) or t(8;2) and t(22;8) with c-MYC on chromosome 8q24 which stimulates proliferation 40% with a p53 mutation
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Large B-cell lymphoma 7-8% of NHL Localization: abdomen, peripheral lymph nodes, skin, bone Lymphoblastic lymphoma 30% of NHL Usually mediastinal localization Anaplastic Large Cell Lymphoma 7-8% of NHL
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Clinical manifestations Duration of symptoms: usually a few days to weeks Non-specific symptoms: fatigue, nausea, anorexia, loss of weigth and/or fever In relation to localisation of NHL: Abdomen: especially the ileocecal region, mesentery, retroperitoneum, ovaries > painfull, spasms, vomiting Obstipation, intussusception Apendicitis-like Ileus, ascites
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Mediastinum: Mostly anterior or middle part of mediastinum > cough, stridor, dyspnea, wheezing Edema of the neck and face with marked dyspnea may indicate SVCS Pain of the back or abdomen Pleural effusion
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Involvement of adenoid and tonsils, nasopharyngeal lymph nodes, parotid gland swelling
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Peripheral lymph nodes: Mostly cervical, supraclavicular and inguinal Lymph nodes are firm, not usually tender, but involving multiple lymph nodes that usually occur unilaterally Other locations: CNS, cranial and peripheral nerves, skin, muscles, bone, thorax, gonads, parotid gland, epidural region→ spinal cord compression
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Differential diagnosis Lymph node enlargement in infectious diseases Autoimmune lymphoproliferative syndrome Hodgkin Lymphoma metastatic disease of sarcomas or neuroblastomas ALL: if more than 25% blasts = ALL, if less= NHL IV stage
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Diagnosis:-histology-stage Histological (lymph nodes, peripheral blood, bone marrow or fluid resulting from pleural effusion or ascites) In abdominal stage: laparotomy In SVCS- emergency situation, noninvasive biopsy or pretreatment with chemotherapy or/and radiotherapy Morphological, immunophenotypical and molecular /cytogenetic analyses Serum lactate dehydrogenase (LDH) Serum uric acid Bone marrow aspiration CSF analysis
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Radiological diagnosis Ultrasound Conventional X-ray CT of the thoracic, abdomen and skeletal disease MRI for CNS PET (positron –emmision tomography) Bone scan
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Staging ( Murphy/St.Jude) I- a single tumor (extranodal) or single anatomical area (nodal), excluding mediastinum or abdomen II- a single tumor (extranodal) with regional involvement On same side of diaphragm a/ two or more nodal areas b/ two single (extranodal) tumors with or without regional node involvement A primary gastrointestinal tract tumor (usually ileocecal) with or without associated mesenteric node involvement; gross complete resection
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III- On both sides of the diaphragm: a/two single tumors (extranodal) b/two or more nodal areas ALL primary intrathoracic tumors (mediastinal, pleural, thymic) All extensive primary intra-abdominal disease, unresectable All primary paraspinal or epidural tumors regardless of other sites IV- Any of the above with initial CNS or bone marrow involvement (less than 25%)
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Stages I + II: 10 – 20% of all NHL Stages III+ IV: 80 – 90% of all NHL
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Treatment Induction therapy should be begun as soon as possible! Tumor lysis syndrome prophylaxis or treatment Chemotherapy (in Poland -according to BFM protocols) Surgical procedure: total resection in I or II stage with localized masses only BMT ( auto) Overall long-term survival >80%
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Hodgkin Disease
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Progressive, painless enlargement of lymph nodes with continuous extension between lymph node region Pathogmonic histologically :Reed-Sternberg cells Incidence: 5-7% of all neoplasia in childhood Boys more than girls Rare before 5 years; increasing until the age of 11 years Peak incidence between 15 and 35 years of age
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Etiology and pathogenesis Correlation with EBV infection, genetic predisposition, disturbed humoral and cellular immune response High incidence in patients with LE, rheumatoid disorders, ataxia teleangiectasia, agammaglobulinemia
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Clinical presentation Painless enlargement of lymph nodes, mostly in the cervical and supraclavicular regions Swollen lymph nodes are firm, not inflammatory and painfull to palpation Most common involved lymph nodes: cervical (75%), supraclavicular(25%), axillary, infradiaphragmatic Extranodal involvement: lung, bone, liver In mediastinal involvement: a cough, sometimes with dyspnea, dysphagia and enlargement of the vessels of the neck (SVCS)
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B symptoms (in 20 -30%) Fever higher than 38° C Night sweats Loss of more than 10% body weight Sometimes: pruritus and/or nausea
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Open biopsy Not fine-nedle biopsy!!! Histological classification: Lymphocyte predominance Nodular sclerosing Lymphocyte-depleted Mixed cellular
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Laboratory analyses Blood Bone marrow Ferritin, LDH Immunological analyses Stage- Radiological evaluation Chest (x-ray, CT) Abdomen (usg, CT) Bone scintigraphy PET-CT
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HL
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Staging classification I: involvement of a single lymph node region(I) or a single extralymphatic organ (IE) II:two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of an extralymphatic organ or site one or more lymph node regions on the same side of the diaphragm III: involvement of lymph node regions on both sides of the diaphragm (III) which may be accompanied by involvement of an extralymphatic organ (IIIe) or site, or both (IIIES) IV: diffuse or disseminated process A: absence of B symptoms B: presence of:loss of 10% or more body weight in 6 months preceding diagnosis, unexplained fever, drenching night-sweat, pruritus
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Differential diagnosis Toxoplasmosis, tuberculosis, atypical infections NHL Mononucleosis Metastatic disease Thymus hyperplasia Rheumatoid arthritis, LE Sarcoidosis
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Treatment Procedure depends on stage and histopathology Chemo- and radiotherapy (EuroNet protocol) Prognosis Stage I/II EFS >90% Stage III/IV EFS 70-80%