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Pathology of Atherosclerosis PowerPoint Presentation

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Description : The Pathology of Atherosclerosis: Microscopic features

Tags : Atherosclerosis,Microscopic,atheromatous,lumen,arterial lesions

Published on : Jun 01, 2022 | Views : 3560 | Downloads : 11

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Slide 1-

The Pathology of Atherosclerosis:Microscopic features Farah, pathology postgraduate Supervisor: Professor Gang Chen
Slide 2-

Atherosclerosis and the Arterial Wall From Stary HC. Atlas of Atherosclerosis: Progression and Regression. 2nd ed. New York: Parthenon Publishing; 2003. Insull W Jr. Am J Med. 2009;122:S3S14. Lumen Lipid-Rich Necrotic Core Fibrous Cap Atheroma Normal Media Adventitia Intima Definition Progressive luminal narrowing of coronary arteries caused by development of atheromatous plaque composed of lipids, inflammatory cells and connective tissue
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Developmental Pathology of Arterial Lesions Thin fibrous cap atheroma. From Virmani R et al. Arterioscler Thromb Vasc Biol. 2000;20:1262-1275; used with permission. Healed plaque rupture. From Stary HC. Atlas of Atherosclerosis: Progression and Regression. 2nd ed. New York: Parthenon Publishing; 2003; used with permission. Stenosis (cross section of anterior descending coronary artery). From Stary HC. Atlas of Atherosclerosis: Progression and Regression. 2nd ed. New York: Parthenon Publishing; 2003; used with permission. Thin fibrous cap Lipid-rich necrotic core Older fibrous cap Newer fibrous cap Insull W Jr. Am J Med. 2009;122:S3S14.
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Summary: Pathology of Atherosclerosis ACS = acute coronary syndromes. From Virmani R et al. Arterioscler Thromb Vasc Biol. 2000;20:1262–1275.Insull W Jr. Am J Med. 2009;122:S3S14.
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Development of atherosclerosis follows a predictable path from initiation phase to progression and development of lipid rich atheromatous plaque to complications leading to ischemic events Numerous risk factors for the development of coronary artery disease are common among patients, including obesity, smoking, dyslipidemia and hypertension Typical atherosclerotic plaque shows a well-formed necrotic core and overlying fibrous cap; smooth muscle cells, macrophages, lymphocytes, connective tissue components and calcification are variably present
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Acknowledgement I'm extremely grateful to Professor Zi-Li Lv (吕自力) for making these microscopic slides available to us online. I’d also like to express my deepest thanks to Professor Gang Chen (陈罡) for his supervision and guidance. Finally, I would also like to thank colleagues and other teachers for their support and help.
Slide 7-

Thank You