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Outer Hair Cells PowerPoint Presentation

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Description : The role outer hair cells play in our ability to hear.

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Published on : May 17, 2021 | Views : 1515 | Downloads : 5

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Slide 1-

Outer Hair Cells By E. L. Hyland
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Where Are They? Inner Ear -> Cochlea -> Scala Media -> organ of Corti Settled on top of the Dieter cells. Distal to the pillar cells. Sits on Basilar Membrane. Courtesy www.ifd.mavt.ethz.ch Courtesy www.neuroreille.com
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Supporting Cells Deiter cells Hensen cells Claudius cells Boettcher Cells Courtesy quizlet.com
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Parts Cell Body- cylindrical Cuticular Plate Endolymph Cortilymph Stereocilia Tiplinks Move together No kinocelia in humans Instead: Basal body Resting potential Courtesy michaeldmann.net
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Afferent and Efferent Nerves Spiral Ganglion Afferent nerves Type II Non-myelenated Efferent nerves Myelenated SOC Contralateral MSO Courtesy quizlet.com
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Active Amplification Inside the cochlea, the traveling wave creates metabolic mechanisms that amplify signals. Outer hair cells at the base of the basal membrane are more tuned to high frequencies and OHC at the apex are more tuned to low frequencies. Two Purposes: Resonant system becomes more highly tuned. Amplification
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Cochlear Microphonic Similar to OHC, a microphone takes auditory information and changes it into electrical information. A gross potential is generated by cochlear hair cells that can be recorded. These recordings are found on ABRs. Reflects the transduction current flowing through the outer hair cells
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OHC Motility/Prestin Depolarization Hyperpolarization Prestin Courtesy quizlet.com
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Shearing Mechanical energy to electrochemical energy Stereocilia Tiplinks Basil Membrane and tectorial membrane Courtesy bms.ed.ac.uk
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Frequency Selectivity Most apparent between 0 and 50 dB SPL Best frequencies enhance low sound levels approximately 40-60 dB SPL. >60 dB SPL gains lessen and selectivity declines Damaged cochlea- no gain
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OHC Damage Ototoxic drugs Presbycusis Loud noise Courtesy dontlosethemusic.co.nz
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Resources Ashmore, J. (2008). Cochlear outer hair cell motility. Physiological Reviews, 88(1), 173-210. Dallos, P. (2008). Cochlear amplification, outer hair cells and prestin. Current Opinion in Neurobiology, 18(4), 370-376. Santarelli, R., Scimemi, P., Dal Monte, E., & Arslan, E. (2006). Cochlear microphonic potential recorded by transtympanic electrocochleography in normally-hearing and hearing-impaired ears. Acta Otorhinolaryngologica Italica : Organo Ufficiale Della Società Italiana Di Otorinolaringologia e Chirurgia Cervico-Facciale, 26(2), 78-95. Zenner, H. P. (1997). The role of outer hair cell damage in the loss of hearing. Ear, Nose, & Throat Journal, 76(3), 140, 143.