Download Free Medical Mitochondria PowerPoint Presentation

Mitochondria PowerPoint Presentation

DOWNLOAD MEDICAL POWERPOINT PRESENTATION

About This Presentation

Description : Check out this medical presentation on Genetics, which is titled "Mitochondria", to learn about Mitochondria, a double membrane-bound organelle found in most eukaryotic organisms.

Tags : Genetics, Mitochondria, double membrane-bound organelle, eukaryotic organisms

Published on : Aug 29, 2021 | Views : 3144 | Downloads : 4

Shareable Url :

Embed Code :

Comment

Transcript

Slide 1-

Mitochondria 90% of ATP generated there 10 to 1000s per cell (highest in brain, skeletal muscle, heart, kidney, liver) About 50 known mutations of human mitochondrial DNA Chapter 12 (pp. 349-354)
Slide 2-

ppt slide no 2 content not found
Slide 3-

About 90 different proteins make up the Electron Transport Chain Figure 12.2
Slide 4-

Endosymbiosis
Slide 5-

Mitochondrial DNA …the “25th chromosome”? 16,568 bp 2 Ribosomal RNAs 22 Transfer RNAs 13 Proteins 2-10 copies per organelle Figure 12.3
Slide 6-

13 of the 90 Electron Transport Chain proteins are encoded by mitochondrial DNA. The other 77 (plus about 1000 other mitochondrial proteins) are encoded by nuclear DNA. ...So, mitochondria truly are a cooperative venture between two genetic systems!
Slide 7-

Mitochondrial Division
Slide 8-

Sperm mitochondria destroyed once in egg cell…
Slide 9-

Figure 12.4 Affected females have affected offspring Affected males don’t Called “Maternal Inheritance”
Slide 10-

≈ 100,000 mitochondria in an immature egg cell, but only 100 in a mature egg cell
Slide 11-

Homoplasmy = Same mitochondrial genome in all tissues of a body. Heteroplasmy = More than one mitochondrial genome in a body, but can have various ratios in different tissues.
Slide 12-

Homoplasmy = Same mitochondrial genome in all tissues of a body. Heteroplasmy = More than one mitochondrial genome in a body, but can have various ratios in different tissues. This one is more common !
Slide 13-

If a mutation occurs in the mitochondrial DNA of the mother, the severity of the disease in the offspring depends on: Amount of mutant mitochondria inherited by child Partitioning of mutant mitochondria to different tissues of the body Energy needs of different tissues (higher in heart, muscle, brain, liver)
Slide 14-

Mitochondrial Encephalomyopathy with Lactic Acidosis & Strokelike Episodes = ‘MELAS’ (pp. 355-357) Most common mitochondrial disease Recurrent strokes before age of 40 Myopathy (muscle weakening) Lower pH (due to lactic acid build-up) Deafness Droopy eyelids Short stature Diabetes
Slide 15-

ppt slide no 15 content not found
Slide 16-

MELAS mutation is in the gene for the tRNA for Leucine 80% of mutations reduced protein synthesis shorter tRNA half-life no new proteins < See clumps of deformed mitochondria in arteries of brain….stroke?
Slide 17-

ppt slide no 17 content not found
Slide 18-

Kearns-Sayre Syndrome = KSS (pp. 358-359) Ophthalmoplegia (paralysis or weakness of one or more eye muscles) Degeneration of pigment layer of retina Cardiac abnormalities Neurological abnormalities Onset at age 20 (fatal in few years) Large deletions (1000s bp) of mito DNA; duplications Is not typically inherited, but rather is ‘sporadic’ (meaning it just seems to show up in people)
Slide 19-

Ophthalmoplegia
Slide 20-

Mitochondrial DNA 16,568 bp Figure 12.3 ¼ of chromosome often deleted
Slide 21-

ppt slide no 21 content not found
Slide 22-

Free-Radical “atom or molecule with an unpaired electron” They are very reactive.
Slide 23-

Skin aging/wrinkling
Slide 24-

Skin aging/wrinkling
Slide 25-

What can you do to prevent Free-Radical damage? Get your Vitamins-E and-C and β-Carotene (Vitamin-A precursor). These are ‘anti-oxidants’. Regular exercise. Although exercise generates free-radicals if you do it enough your body responds by absorbing them. Eat less. Lab rats on limited diets lived 50% longer, Fruitflies lived 30% longer. Reduce smoking, drinking alcohol, fatty foods Get less sun exposure.
Slide 26-

Mitochondrial DNA 16,568 bp Figure 12.3 This region doesn’t code for anything
Slide 27-

Mitochondria DNA can be used to study our past: Maternally inherited only No recombination Non-coding region collects mutations more quickly than nuclear DNA (less of a repair mechanism) Applications: Evolution & Forensics
Slide 28-

Shot in 1882. Buried on his parent’s farm in Missouri.
Slide 29-

2000
Slide 30-

DNA testing was done on the remains of a Vietnam soldier who was buried in the Tomb of the Unknowns at Arlington National Cemetery Remains of unidentified soldiers from WW I and WW II, Korea & Vietnam
Slide 31-

In this case, they did RFLP analysis of DNA from the mitochondria. Extracted mito DNA from the buried bones and compared that to the DNA of the supposed mother and siblings
Slide 32-

It matched those of United States Air Force First Lieutenant Michael Joseph Blassie. Lieutenant Blassie's remains were returned to his family in July 1998, and were buried in his hometown of St. Louis, Missouri. Remains of unidentified soldiers from WW I and WW II, Korea & Vietnam