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Challenges in Personalised Medicine PowerPoint Presentation

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Description : Check out this medical PowerPoint presentation titled "Challenges in Personalised Medicine".

This medical PowerPoint presentation is about personalized medicine is an approach to medical treatment that considers an individuals unique genetic, environmental, and lifestyle factors to determine the best course of treatment. While it has the potential to revolutionize healthcare, there are several challenges that must be addressed for personalized medicine to become widely adopted. Some of these challenges are listed in this presentation.

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Published on : Jun 23, 2023 | Views : 806 | Downloads : 0

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Challenges in Personalised Medicine
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Personalised medicine (PM) is a medical model that proposes to customise medical decisions, practices, and treatments for the individual patient. Personalised medicine will require the development of targeted medicines. For personalised medicine to make progress, new findings from molecular research, and new technologies (such as ‘omics’ technologies), must be translated (adapted) for use in medicines development and approved therapy. 2 Personalised Medicine
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An advantage of developing targeted medicines is the increase in the efficiency of clinical trials. Fewer new medicines should fail at each stage of the development process if they are targeted at a known cause of the disease. The use of biomarkers will be central to personalised medicine. Validation of unique and predictive biomarkers measuring treatment outcomes will need to be in place before medicines developed in this way can be authorised. 3 Advantages
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Companion diagnostics are necessary tests that select patients before a medicine is given. They may: show who is likely to respond to the medicine (‘responders’ and ‘non-responders’); identify patients at high risk for adverse reactions; and help the doctor to select an appropriate dose that is both safe and effective. 4 Companion Diagnostics
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Proper design and validation of the diagnostic test is essential to get the best outcome from the medicine and for the patient. Companion diagnostics should have an ‘intended use’ or ‘indications for use’. Companion diagnostics may include tests directly on the patient such as electrocardiography (ECG) or diagnostic imaging such as MRI. Tests carried out on samples taken from a patient (such as DNA tests) are generally considered by regulatory authorities to provide the most valid evidence. 5 Validation and Intended Use
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Companion Tests should include the following elements: the target population for whom the test is intended (such as individuals with particular genotypes(genetic make-up) or phenotypes (characteristics), why the measurement is being done – the ‘clinical purpose’ such as to help with diagnosis, assessing how the disease is likely to develop (prognosis), and monitoring, what is measured, identified, or detected such as a specific gene or protein, 6 Companion Tests
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what kind of measurement the test makes, including whether the test is qualitative (looks at observations and descriptions), or semi-quantitative and quantitative (looks at numbers), the sample type and where it is taken from e.g. whole blood, cerebrospinal fluid, the setting in which the diagnostic device is meant to be used, for example, in a laboratory or at ‘point-of-care’ and what type of equipment is required to perform the test, the target condition, a particular disease, disease stage, health status, or other identifiable condition or event. 7 Companion Tests
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There are particular ethical challenges for researchers who work with genetic and genomic data. It is important that they consider privacy and keeping data confidential and making sure participants in trials understand what they are agreeing to - ‘informed consent’. 8 Challenges
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Even when medicine is targeted for a specific sub-population of patients, it is still possible that patients with the ‘same disease’ but in different sub-groups might be prescribed the medicine. This could lead to: a lack of response to the treatment, a delay in the patient receiving a treatment that is better for them, a waste of the medicine itself, an adverse reaction that could have been avoided. 9 Challenges
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With personalised medicine, the patient with a disease should have more reassuring information prior to treatment, for example: that a medicine is likely to work well for them, that they are unlikely to suffer from side effects with a particular treatment, where side effects are unavoidable, better knowledge about them and how severe they might be should make it easier for the patient to decide and plan for the treatment and to fit it into their daily life. 10 Patient Experience
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Are patients ready for this? Are healthcare professionals skilled enough and ready to communicate about it with their patients? With personalised medicine, there may exist more or even different information about the available treatment options for the patient and doctor to understand and discuss. Patients who find this difficult will need good support from their doctors. 11 Personalised Medicine
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Patients and their doctors will need to discuss the pros and cons when making decisions about testing. It may be necessary to do more tests than patients are used to in order to make personalised medicine possible. If a test predicts how likely a patient is to respond to a medicine, the result might be expressed for example as a ratio (1 in 3) or as a percentage (33 %). People have different ways of interpreting risk, and doctors will need to support them in interpretation of risks. 12 Supporting Patients
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Genomics England Nuffield Council on Bioethics (2010) Medical Profiling and online medicine: the ethics of personalised healthcare in a consumer age Corpet, A. & Almouzni, G. (Dec 2006-Jan 2007). Sciences et Avenir, 149 13 References