Download Free Medical Blood - Bone Marrow PowerPoint Presentation

Blood - Bone Marrow PowerPoint Presentation

DOWNLOAD MEDICAL POWERPOINT PRESENTATION

About This Presentation

Description : Bone and bone marrow PowerPoint presentation is one of MedicPresents' medical PowrPoint presentations. This bone PPT presentation gives an introduction to bone and bone marrow along with Erythrocytes, RBCs, cells, Biconcave discs, NUCLEUS, Hemoglobin, Platelets, Megakaryocytes etc.

Tags : Blood, Peripheral, Erythrocytes, RBCs, cells, Biconcave discs, NUCLEUS, Hemoglobin, Platelets, Megakaryocytes, bone, marrow, Leukocytes, GRANULOCYTES, Neutrophils, Basophils, Eosinophils, WBCs, WBC, RBC, Band Cell

Published on : Aug 15, 2016 | Views : 6978 | Downloads : 20

Shareable Url :

Embed Code :

Comment

Transcript

Slide 1-

Blood - Bone Marrow Presented by: Khushbu Shrivastava Gupta Editor, MedicPresents Master of Technology (M.Tech.), Biotechnology - Vellore Institute of Technology (VIT)
Slide 2-

Formed Elements of the Blood
Slide 3-

Peripheral Blood: Erythrocytes RBCs constitute the largest number of cells in the blood Biconcave discs NO NUCLEUS Contain Hemoglobin
Slide 4-

Peripheral Blood: Platelets Derived from Megakaryocytes in bone marrow – formed from small bits of Megakaryocyte cytoplasm Function in blood clotting
Slide 5-

Peripheral Blood: Leukocytes GRANULOCYTES Neutrophils Basophils Eosinophils AGRANULOCYTES Lymphocytes (T and B cells) Monocytes (Macrophages)
Slide 6-

Peripheral Blood: Leukocytes GRANULOCYTES Neutrophils Basophils Eosinophils
Slide 7-

Granulocytes: Neutrophils Most numerous WBC in blood Multilobed nucleus Granules: Azurophilic granules Specific granules Function 1st wave of cells in acute inflammation; can phagocytose bacteria
Slide 8-

Granulocytes: Basophils Rare! Lobulated nucleus often obscured by granules Dark Blue Granules Hydrolytic enzymes, heparin sulfate, histamine, SRS Function Role in hypersensitivity and anaphylaxis
Slide 9-

Granulocytes: Eosinophils Bilobed nucleus Bright pink Granules Arginine rich major basic protein, peroxidase, histaminase, arylsulfatase Function: Important in allergic rxns, parasitic infections, and phagocytosis of Ab-Ag complexes
Slide 10-

Agranulocytes: Monocytes Largest WBCs in blood smear Migrate through blood to the tissues; once in tissues they differentiate into phagocytes (macrophages)
Slide 11-

Agranulocytes: Lymphocytes About size of RBCs Function Main functional cells of adaptive immune system T cells B cells
Slide 12-

Questions Which of the following cell types would be expected to be increased in number with a bacterial infection? Viral? Parasitic?
Slide 13-

ppt slide no 13 content not found
Slide 14-

RBC Development Watch for trends!
Slide 15-

Proerythroblast Biggest in lineage Large central nucleus with one or two nucleoli Basophilic cytoplasm b/c ribosomes Look for Golgi ghost
Slide 16-

Basophilic Erythroblast Smaller than proerythroblast Checkerboard nucleus (heterochromatic) Intense basophilia (lots of ribosomes!)
Slide 17-

Proerythroblast vs Basophilic Erythroblast
Slide 18-

Polychromatophilic Erythroblast Smaller than basophilic erythroblast Smaller intensely heterochromatic nucleus Purple/lilac cytoplasm mix of basophilia from ribosomes and growing eosinophilia from hemoglobin LAST MITOTIC STAGE!
Slide 19-

Normoblast Smaller than polychromatophilic erythroblast Small, compact, intensely staining nucleus that is getting ready to be extruded Eosinophilic cytoplasm due to abundant hemoglobin
Slide 20-

Reticulocyte Immature RBC that has polyribosomes Appear as polychrom-atophilic erythrocyte on blood smear When stained with a special (supravital) stain  Reticulocyte
Slide 21-

Erythrocyte Smallest Eosinophilic due to hemoglobin NO NUCLEUS!
Slide 22-

Erythropoiesis
Slide 23-

ppt slide no 23 content not found
Slide 24-

Development of Granulocytes
Slide 25-

What are the Granulocytes? These are cells of the immune system (White Blood Cells) that contain vesicles. The vesicle contents vary among cell lines and stain differently. Neutrophils (polymorphonuclear or PMN cells) Eosinophils Basophils
Slide 26-

Trend of Development Larger to smaller Azure granules to specific granules Round nucleus to altered shape nucleus Granulocyte Lineage: Myeloblast → Promyelocyte → Myelocyte → Metamyelocyte → Band → Granulocyte (Erythroid: Proerythroblast →Basophilic erythroblast → Polychromatophilic erythroblast → Normoblast → Reticulocyte → Erythrocyte)
Slide 27-

Myeloblast Prominent nucleoli
Slide 28-

PROmyelocyte Details Golgi ghost Can’t distinguish type of granulocyte yet Eccentric nucleus Don’t confuse with proerythroblast or basophilic erythroblasts
Slide 29-

Myelocyte Last stage in which mitosis can occur Begin to see who’s a neutrophil, who’s an eosinophil (who’s a basophil) Golgi ghost
Slide 30-

Neutrophilic Myelocyte vs Eosinophilic Myelocyte
Slide 31-

METAmyelocyte nucleus changing shape, not spherical Soooo . . . No more mitosis
Slide 32-

Band Cell Immature granulocyte Elongated nucleus of nearly uniform width; horseshoe/U-shaped
Slide 33-

Finally . . .
Slide 34-

Myeloblast – no granules capable of mitosis Promyelocyte – azurophilic granules Mylocyte – specific granules Metamylocyte – specifc granules nucleus changes shape Band cell – (PMN only) specific granules Mature Granulocyte – specific granules
Slide 35-

Compare what you see . . .
Slide 36-

Megakaryocyte Huge Platelets form from invaginations of this Multilobular nucleus
Slide 37-

Megakaryocyte
Slide 38-

ppt slide no 38 content not found
Slide 39-

Thank You