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Blood - Bone Marrow PowerPoint Presentation

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Description : Bone and bone marrow PowerPoint presentation is one of MedicPresents' medical PowrPoint presentations. This bone PPT presentation gives an introduction to bone and bone marrow along with Erythrocytes, RBCs, cells, Biconcave discs, NUCLEUS, Hemoglobin, Platelets, Megakaryocytes etc.

Tags : Blood, Peripheral, Erythrocytes, RBCs, cells, Biconcave discs, NUCLEUS, Hemoglobin, Platelets, Megakaryocytes, bone, marrow, Leukocytes, GRANULOCYTES, Neutrophils, Basophils, Eosinophils, WBCs, WBC, RBC, Band Cell

Published on : Aug 15, 2016 | Views : 6733 | Downloads : 20

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Slide 1-

Blood - Bone Marrow Presented by: Khushbu Shrivastava Gupta Editor, MedicPresents Master of Technology (M.Tech.), Biotechnology - Vellore Institute of Technology (VIT)
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Formed Elements of the Blood
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Peripheral Blood: Erythrocytes RBCs constitute the largest number of cells in the blood Biconcave discs NO NUCLEUS Contain Hemoglobin
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Peripheral Blood: Platelets Derived from Megakaryocytes in bone marrow – formed from small bits of Megakaryocyte cytoplasm Function in blood clotting
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Peripheral Blood: Leukocytes GRANULOCYTES Neutrophils Basophils Eosinophils AGRANULOCYTES Lymphocytes (T and B cells) Monocytes (Macrophages)
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Peripheral Blood: Leukocytes GRANULOCYTES Neutrophils Basophils Eosinophils
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Granulocytes: Neutrophils Most numerous WBC in blood Multilobed nucleus Granules: Azurophilic granules Specific granules Function 1st wave of cells in acute inflammation; can phagocytose bacteria
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Granulocytes: Basophils Rare! Lobulated nucleus often obscured by granules Dark Blue Granules Hydrolytic enzymes, heparin sulfate, histamine, SRS Function Role in hypersensitivity and anaphylaxis
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Granulocytes: Eosinophils Bilobed nucleus Bright pink Granules Arginine rich major basic protein, peroxidase, histaminase, arylsulfatase Function: Important in allergic rxns, parasitic infections, and phagocytosis of Ab-Ag complexes
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Agranulocytes: Monocytes Largest WBCs in blood smear Migrate through blood to the tissues; once in tissues they differentiate into phagocytes (macrophages)
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Agranulocytes: Lymphocytes About size of RBCs Function Main functional cells of adaptive immune system T cells B cells
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Questions Which of the following cell types would be expected to be increased in number with a bacterial infection? Viral? Parasitic?
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RBC Development Watch for trends!
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Proerythroblast Biggest in lineage Large central nucleus with one or two nucleoli Basophilic cytoplasm b/c ribosomes Look for Golgi ghost
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Basophilic Erythroblast Smaller than proerythroblast Checkerboard nucleus (heterochromatic) Intense basophilia (lots of ribosomes!)
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Proerythroblast vs Basophilic Erythroblast
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Polychromatophilic Erythroblast Smaller than basophilic erythroblast Smaller intensely heterochromatic nucleus Purple/lilac cytoplasm mix of basophilia from ribosomes and growing eosinophilia from hemoglobin LAST MITOTIC STAGE!
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Normoblast Smaller than polychromatophilic erythroblast Small, compact, intensely staining nucleus that is getting ready to be extruded Eosinophilic cytoplasm due to abundant hemoglobin
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Reticulocyte Immature RBC that has polyribosomes Appear as polychrom-atophilic erythrocyte on blood smear When stained with a special (supravital) stain  Reticulocyte
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Erythrocyte Smallest Eosinophilic due to hemoglobin NO NUCLEUS!
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Erythropoiesis
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Development of Granulocytes
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What are the Granulocytes? These are cells of the immune system (White Blood Cells) that contain vesicles. The vesicle contents vary among cell lines and stain differently. Neutrophils (polymorphonuclear or PMN cells) Eosinophils Basophils
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Trend of Development Larger to smaller Azure granules to specific granules Round nucleus to altered shape nucleus Granulocyte Lineage: Myeloblast → Promyelocyte → Myelocyte → Metamyelocyte → Band → Granulocyte (Erythroid: Proerythroblast →Basophilic erythroblast → Polychromatophilic erythroblast → Normoblast → Reticulocyte → Erythrocyte)
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Myeloblast Prominent nucleoli
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PROmyelocyte Details Golgi ghost Can’t distinguish type of granulocyte yet Eccentric nucleus Don’t confuse with proerythroblast or basophilic erythroblasts
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Myelocyte Last stage in which mitosis can occur Begin to see who’s a neutrophil, who’s an eosinophil (who’s a basophil) Golgi ghost
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Neutrophilic Myelocyte vs Eosinophilic Myelocyte
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METAmyelocyte nucleus changing shape, not spherical Soooo . . . No more mitosis
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Band Cell Immature granulocyte Elongated nucleus of nearly uniform width; horseshoe/U-shaped
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Finally . . .
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Myeloblast – no granules capable of mitosis Promyelocyte – azurophilic granules Mylocyte – specific granules Metamylocyte – specifc granules nucleus changes shape Band cell – (PMN only) specific granules Mature Granulocyte – specific granules
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Compare what you see . . .
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Megakaryocyte Huge Platelets form from invaginations of this Multilobular nucleus
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Megakaryocyte
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Thank You