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Antiviral Drugs PowerPoint Presentation

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Description : Check out this medical titled "Antiviral Drugs” by S.Bohlooli, PhD.

This medical is about antiviral drugs, medications used to treat viral infections by specifically targeting the virus and inhibiting its ability to replicate or infect host cells. These drugs work by interfering with different stages of the viral life cycle, such as viral entry, viral replication, assembly, and release.

There are several types of antiviral drugs available, including Nucleoside/nucleotide analogs, Protease inhibitors, Entry inhibitors, Polymerase inhibitors, and Immunomodulators.

Tags : Antiviral Drugs, viral infections, virus, influenza, herpes simplex virus, hepatitis B and C, HIV, COVID-19, Neuraminidase inhibitors, Nucleoside analogues, Protease inhibitors, Polymerase inhibitors, Infectious Disease, Infectious Disease

Published on : Jun 01, 2023 | Views : 1285 | Downloads : 3

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Antiviral drugs By S.Bohlooli, PhD School of Medicine, Ardabil University of Medical Sciences
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The major sites of antiviral drug action.
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Chemical structures of some antiviral nucleoside and nucleotide analogs
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Chemical structures of some antiviral nucleoside and nucleotide analogs
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Chemical structures of some antiviral nucleoside and nucleotide analogs
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Agents to treat Herpes Simplex Virus (HSV) & Varicella Zoseter Virus (VZV) infections Acyclovir Valcyclovir Famciclovir Penciclovir Trifluridine
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Agents to treat Cytomegalovirus (CMV) infections Ganciclovir Valganciclovir Cidofovir Foscarnet Fomivirsen
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Anitretroviral agents:Nucloside Reverse Transcriptase Inhibitors (NRTIs) Zidovudine Didanosine Lamivudine Zalcitabine Stavudine Abacavir
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Anitretroviral agents:Nucleutide inhibitors Tenofovir
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Anitretroviral agents:NonNucleoside Reverse Transcriptase Inhibitors (NNRTIs) Nevirapine Delaviridine Efavirenz
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Anitretroviral agents:Protease Inhibitors Saquinavir Ritonavir Lopinavir Ritonavir Indinavir Nelfinavir Ampernavir
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Fusion Inhibitors Enfuvirtide (HIV) Docosanol (HSV)
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Anti-Hepatitis agents Lamivudine Adefovir Interferon alpha Pegylated interferon alpha Ribavirin
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Anti-Influenza Agents Amantadine Rimantadine Zanamivir Oseltamivir
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Other Antiviral agents Palivizumab Imiquimod
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Replicative cycles of herpes simplex virus, an example of a DNA virus, and the probable sites of action of antiviral agents.
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Replicative cycles of influenza, an example of an RNA virus, and the loci for effects of antiviral agents.
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Mechanism of action of antiherpes agents
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Replicative cycle of HIV-1, an example of a retrovirus, showing the sites of action of antiviral agents. Various antiviral agents are shown in blue. Key: RT, reverse transcriptase; cDNA, complementary DNA; mRNA, messenger RNA; Tat, a protein that regulates viral transcription and affects the rate of replication; RNaseH, ribonuclease H; gp120, envelope glycoprotein.
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Life cycle of HIV
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Entry Inhibitors Efuvirtide (T-20) 36-amino acid peptide binds to gp41 viral envelope glycoprotein Resistance can occur but there is no cross resistance Drug administration subcutaneously in combination with other antiretroviral drugs Side effects: Local injection site reaction, hypersensitivity reaction,Eosinophilia Maraviroc binds specifically and selectively to CCR5
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Integrase Inhibitors Raltegravir A pyrimidinone analog that binds integrase
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