Download Free Medical ADVERSE DRUG REACTIONS PowerPoint Presentation

ADVERSE DRUG REACTIONS PowerPoint Presentation

DOWNLOAD MEDICAL POWERPOINT PRESENTATION

About This Presentation

Description : Check out this medical presentation on Adverse Drug Events, which is titled "ADVERSE DRUG REACTIONS", to know about Adverse Drug Reactions, any noxious change which is suspected to be due to a drug.

Tags : Adverse Drug Events, Adverse Drug Reactions

Published on : Jul 20, 2021 | Views : 2852 | Downloads : 7

Shareable Url :

Embed Code :

Comment

Transcript

Slide 1-

ADVERSE DRUG REACTIONS Prof . R . K. DIXIT Dept. of Pharmacology & Therapeutics King George’s Medical University, Lucknow dixitkumarrakesh@gmail.com
Slide 2-

ADVERSE DRUG REACTION Any noxious change which is Suspected to be due to a drug At doses normally used in man May requires treatment or decrease in dose or Caution in the future use of the same drug
Slide 3-

ADVERSE DRUG EVENT (ADE) Any untoward occurrence that may present during medical treatment, But Does not necessarily have a causal relationship with the treatment
Slide 4-

Incidence of ADR more Polypharmacy Elderly Children Patient with multiple diseases Pregnancy Malnourished Immunosuppression Drug Abusers and addicts Develop Immediately or Prolonged medication or After stopping.
Slide 5-

GRADING OF SEVERITY OF ADVERSE DRUG REACTIONS : Minor : No therapy, antidote or prolongation of hospitalization is required. Moderate: Requires change in drug therapy, specific treatment or prolongs hospital stay. Severe: Potentially life-threatening, causes permanent damage or requires intensive medical treatment. Lethal : Directly or indirectly contributes to death of the patient.
Slide 6-

CLASSIFICATIONS OF ADR A (Augmented) B (Bizarre) C (Continuous) D (Delayed) E (Ending Use) F (Failure of Efficacy) Broadly Type- A (Predictable)- Based on pharmacological properties Type- B (Non-predictable) – Based on Immunological response and genetic makeup of person
Slide 7-

TYPE A- AUGMENTED These are based on the pharmacological properties of the drug so can be predicted. They are common and account for 75% of ADRs Dose related and preventable mostly reversible. Examples:- Anticoagulants (e.g., warfarin, heparin) – bleeding Anti-hypertensives (e.g.. α1-antagonists) – hypotension Anti-diabetics (e.g. insulin) - hypoglycemia Predictable
Slide 8-

TYPE B- BIZZARE OR UNPREDICTABLE Have no direct relationship to the dose of the drug or the pharmacological mechanism of drug action. Develop on the basis of: Immunological reaction on a drug (Allergy) Genetic predisposition (Idiosyncratic reactions) More serious clinical outcomes with higher mortality and morbidity. Mostly require immediate withdrawal of the drug. Un-predictable
Slide 9-

TYPE C – CHRONIC (CONTINOUS) USE They are mostly associated with cumulative-long term exposure Example:- Analgesic (NSAID)– interstitial nephritis, papillary sclerosis, necrosis Predictable
Slide 10-

TYPE D – DELAYED They manifest themselves with significant delay Teratogenesis -Thalidomide – Phocomelia (flipper-like fore limbs) Mutagenesis/Cancerogenesis Others: Tardive dyskinesis – during L-DOPA Parkinson disease treatment Predictable
Slide 11-

TYPE E – END OF USE Drug withdrawal syndromes and rebound phenomenons Example – sudden withdrawal of long term therapy with -blockers can induce rebound tachycardia and hypertension Predictable
Slide 12-

PHARMACOVIGILANCE (DAUP) The 'science and activities relating to the detection, assessment, understanding and prevention of adverse effects or any other drug related problems’ The information generated is useful in educating doctors and in the official regulation of drug use. It has an important role in rational use of medicines, as it provides the basis for assessing safety of medicines.
Slide 13-

Various activities involved in pharmacovigilance are: Postmarketing surveillance and other methods of ADR monitoring such as voluntary reporting by doctors prescription event monitoring. Dissemination of ADR data through 'drug alerts', 'medical letters,' advisories sent to doctors by pharmaceuticals and regulatory agencies. Changes in the labelling of medicines indicating restrictions in use or statuary warnings, precautions, or even withdrawal of the drug.
Slide 14-

The Uppsala Monitoring Centre (Sweden) is the international collaborating centre. In India, National centre is located at Ghaziabad Peripheral Centres at Medical college levels and tertiary and above hospitals Reports generated by doctors, paramedical staff--to peripheral centre...National centre...Uppsala Monitoring Centre...Compilation of data..analysis of data..causal association is confirmed..guidelines issued regarding the safe use of medicine or (restricted use or withdrawal from the market)
Slide 15-

PREVENTION OF ADVERSE EFFECTS TO DRUGS Avoid inappropriate use of drugs . Appropriate drug administration (Rational Therapeutics) Dose Dosage form Duration Route Frequency Technique Ask for previous history of drug reactions and allergies Always suspect ADR when new symptom arises after initiation of treatment. ( No new drug for new symptom). Ask for laboratory findings like serum creatinine etc.
Slide 16-

Categorized into: Side effects- Secondary effects Toxic effects Intolerance Idiosyncrasy Drug allergy Photosensitivity Drug dependence Drug withdrawal reactions Teratogenicity Mutagenicity and Carcinogenicity Drug induced diseases (Iatrogenic disorders or Iatrogenicity) Beware of – Iatrogenic, Idiosyncrasy, Idiopathic, Intolerance
Slide 17-

SIDE EFFECTS Unwanted often unavoidable Pharmaco-dynamic effects. Occur at therapeutic doses. Predictable Examples. Benzodiazepines- Motor in coordination H1 Anti-histaminics- Sedation An effect may be therapeutic in one context but side effect in another context Depression of A-V conduction is the desired effect of digoxin in atrial fibrillation, but the same may be undesirable when it is used for CHF. Constipation by codeine is side effect but can be used as therapeutic effect in patient with loose motions
Slide 18-

SECONDARY EFFECTS Indirect consequences of a primary action of the drug. E.g. corticosteroids weaken host defence mechanisms so that latent tuberculosis gets activated.
Slide 19-

TOXIC EFFECTS (Poisonous effect) It is the dose and duration which makes a poison.... Paracelsus Over dose or prolonged use. The effects are predictable and dose related. The CNS, CVS, kidney, liver, lung, skin and bone marrow are most commonly involved in drug toxicity.
Slide 20-

Toxicity may result from extension of the therapeutic effect itself, e.g. complete A-V block by digoxin, bleeding due to heparin. Poisoning: Poison is a substance which endangers life by severely affecting one or more vital functions.
Slide 21-

Specific antidotes such as receptor antagonists, chelating agents or specific antibodies are available for few poisons. For others as well as for those poisons which have a selective antagonist general supportive and symptomatic treatment should be done. These measures are: 1. Resuscitation and maintenance of vital functions: maintenance of ABC , body temperature and blood glucose. 2.Termination of exposure (decontamination) 3. Prevention of absorption of ingested poisons. 4. Hastening elimination of the poison by inducing diuresis or altering urinary pH
Slide 22-

INTOLERANCE It is the appearance of characteristic toxic effects of a drug in an individual at therapeutic doses It indicates a low threshold of the individual to the action of a drug Example:- Only few doses of carbamazepine may cause ataxia in some people Un-Predictable
Slide 23-

IDIOSYNCRASY It is genetically determined abnormal reactivity to a chemical. The drug interacts with some unique feature of the individual, not found in majority of subjects, and produces the uncharacteristic reaction. Example :- Chloramphenicol produces nondose-related serious aplastic anaemia in rare individuals. Barbiturates cause excitement and mental confusion in some individuals Un-Predictable
Slide 24-

DRUG ALLERGY It is also called drug hypersensitivity. It is an immunologically mediated reaction producing stereotype symptoms which are unrelated to the pharmacodynamic profile of the drug. It generally occur even with much smaller doses and have a different time course of onset and duration. Un-Predictable
Slide 25-

Allergic reactions occur only in a small proportion of the population exposed to the drug . History of prior sensitization may or may not be evident. The drug or its metabolite acts as antigen (AG) or more commonly hapten (incomplete antigen) and induce production of antibody (AB)/sensitized lymphocytes.
Slide 26-

TYPES OF ALLERGIC REACTIONS A) HUMORAL 1. Type I/ anaphylactic reactions. 2. Type-II / cytolytic reactions. 3. Type-Ill / retarded or Arthus reactions. B) CELL MEDIATED Type-IV (delayed hypersensitivity) reactions.
Slide 27-

PHOTOSENSITIVITY It is a cutaneous reaction resulting from drug induced sensitization of the skin to UV radiation. The reactions are of two types: Photo-toxic :- (T-S) Drug or its metabolite Accumulates in the skin, absorbs light and undergoes a Photochemical reaction followed by Photobiological reaction resulting in Tissue damage (sunburn-like), i.e. erythema, edema, blistering , hyper pigmentation, desquamation. The shorter wave lengths (290-320 nm, UVB) are responsible
Slide 28-

(b) Photo-allergic: (A-L) Drug or its metabolites induce a cell mediated immune response which on exposure to Light of longer wave lengths (320-400 nm, UV -A) Produces a papular or eczematous contact dermatitis like picture. Drugs involved are sulfonamides, sulfonylureas, griseofulvin, chloroquine, chlorpromazine
Slide 29-

DRUG DEPENDENCE Use of drugs for personal satisfaction Higher priority than other basic needs, often in the face of known risks to health. Physical dependence It is an altered physiological state produced by repeated administration of a drug which necessitates the continued presence of the drug to maintain physiological equilibrium. Discontinuation of the drug results in a characteristic withdrawal (abstinence) syndrome. Drugs producing physical dependence are opioids, barbiturates and other depressants including alcohol and benzodiazepines
Slide 30-

Drug abuse : Refers to use of a drug by self medication in a manner and amount that deviates from the approved medical and social patterns in a given culture at a given time. Drug addiction It is a pattern of compulsive drug use characterized by overwhelming involvement with the use of a drug. Procuring the drug and using it takes precedence over other activities
Slide 31-

Drug habituation (Psychological dependence) It denotes less intensive involvement with the drug, so that its withdrawal produces only mild discomfort. Consumption of tea, coffee, tobacco, social drinking are regarded habituating, physical dependence is absent
Slide 32-

DRUG WITHDRAWAL REACTIONS Sudden interruption of therapy with certain other drugs results in adverse consequences, mostly in the form of worsening of the clinical condition for which the drug was being used Example: Acute adrenal insufficiency may be precipitated by abrupt cessation of corticosteroid therapy.
Slide 33-

TERATOGENICITY (Teratos- Monster) Drug to cause foetal abnormalities when administered to the pregnant mother. Drugs can affect the foetus at 3 stages- (i) Fertilization and implantation-conception to 17 days-failure of pregnancy which often goes unnoticed. (ii) Organogenesis-18 to 55 days of gestation most vulnerable period, deformities are produced. (iii) Growth and development-56 days onwards developmental and functional abnormalities can occur, e.g. ACE inhibitors , Thalidomide, Warfarin, Barbiturates,...............................
Slide 34-

MUTAGENICITY AND CARCINOGENICITY Cause genetic defects and cancer respectively. Reactive intermediates which affect genes and may cause structural changes in the chromosomes Even without interacting directly with DNA, certain chemicals can promote malignant change in genetically damaged cells, resulting in carcinogenesis. Examples- anticancer drugs, radioisotopes, estrogens, tobacco...................................................
Slide 35-

DRUG INDUCED DISEASES These are also called iatrogenic (physician induced) diseases, and are functional disturbances (disease) caused by drugs . Hepatitis by isoniazid and Rifampicin Peptic ulcer by salicylates and corticosteroids Retinal damage by chloroquine
Slide 36-

MCQ on ADR Which of the following drugs is teratogenic in nature Warfarin Ampicillin Paracetamol Adrenaline Warfarin
Slide 37-

MCQ on ADR ADRs which are due to typical genetic make of person are known as Side Effects Secondary Effects Iatrogenic disorders Idiosyncratic disorders Iatrogenic disorders
Slide 38-

MCQ on ADR Withdrawal symptoms are common in which of the following drugs Caffenine Paracetamol Opioids Cocaine Opioids
Slide 39-

MCQ on ADR The most dangerous period regarding teratogenic effect is First trimester Second trimester Third trimester Early neonatal life First Trimester
Slide 40-

MCQ on ADR International collaborating centre of Pharmacovigilance is situated at United States of America Australia Sweden United Kingdom Sweden
Slide 41-

Thanks