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Acid-Base Disorders PowerPoint Presentation

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Description : Check out this medical PowerPoint presentation titled "Acid-Base Disorders”.

This medical PowerPoint presentation is about acid-base disorders, a group of medical conditions that are caused by an imbalance of the bodys pH, which is the measure of the acidity or alkalinity of a solution. The pH of the bodys fluids is normally tightly regulated to maintain a balance between acids and bases.

The four primary types of acid-base disorders are Respiratory acidosis, Respiratory alkalosis, Metabolic acidosis and Metabolic alkalosis.

Some common causes of acid-base disorders include kidney disease, diabetes, lung disease, dehydration, and certain medications.

Symptoms of acid-base disorders can vary depending on the type and severity of the condition, but may include difficulty breathing, confusion, fatigue, nausea, and vomiting.

Treatment for acid-base disorders typically involves addressing the underlying cause of the condition and restoring the bodys pH balance. This may include medications, changes in diet and lifestyle, and in some cases, hospitalization for more severe cases.

Tags : Acid-Base Disorders, Respiratory acidosis, Respiratory alkalosis, Metabolic acidosis, Metabolic alkalosis, Nephrology, Nephrology PowerPoint presentation

Published on : Jun 07, 2023 | Views : 1387 | Downloads : 2

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Slide 1-

Acid-Base Disorders
Slide 2-

Close regulation of PH is necessary for cellular enzymes and other metabolic processes,which function optimally at a normal PH (7.35 to 7.45).
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The lungs and the kidneys maintain a normal acid-base balance. Carbon dioxide (CO2) generated during normal metabolism is a weak acid. The lungs prevent an increase in the partial pressure of CO2 (Pco2) in the blood by excreting the CO2 that the body produces. CO2 production varies depending on the body's metabolic needs. The rapid pulmonary response to changes in CO2 concentration occurs via central sensing of the Pco2 and a subsequent increase or decrease in ventilation to maintain a normal Pco2 (35 to 45 mm Hg).
Slide 4-

The kidneys excrete endogenous acids. An adult normaly produces about 1 to 2 mEq/kg/day of hydrogen ions. Children normaly produce 2 to 3 mEq/kg/day of hydrogen ions. The hydrogen ions from endogenous acid production are neutralized by bicarbonate ,potentially causing the bicarbonate concentration to fall. The kidneys regenerate this bicarbonate by secreting hydrogen ions, maintaining the serum bicarbonate concentrarion in the normal range (20 to 28 mEq/L).
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CLINICAL ASSESSMENT OF ACID-BASEDISORDERS Acidemia is a pH below normal (<7.35), and alkalemia is a pH above normal (>7.45). An acidosis is a pathologic process chat causes an increase in the hydrogen ion concentration, and an alkalosis is a pathologic process that causes a decrease in the hydrogen ion concentration.
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A simple acid-base disorder is a single primary disturbance. During a simple metabolic disorder, there is respiratory compensation; the Pco2 decreases during a metabolic acidosis and increases during a metabolic alkalosis. With metabolic acidosis, the decrease in the pH increases the ventilatory drive, causing a decrease in the Pco2. The fall in the CO2 concentration leads to an increase in the pH. This appropriate respiratory compensation for a metabolic process happens quickly and is complete within 12 to 24 hours.
Slide 7-

During a primary respiratory process, there is a slower metabolic compensation, mediated by the kidneys. The kidneys respond to a respiratory acidosis by increasing hydrogen ion excretion, increasing bicarbonate generation, and raising the serum bicarbonate concentration. The kidneys increase bicarbonate excretion to compensate for a respiratory alkalosis; the serum bicarbonate concentration decreases. In contrast to a rapid respiratory compensation, it takes 3 to 4 days for the kidneys to complete appropriate metabolic compensation.
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However, there is a small and rapid compensatory change in the bicarbonate concentration during a primary respiratory process. The expected appropriate metabolic compensation for a respiratory disorder depends on whether the process is acute or chronic.
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A mixed acid-base disorder is present when there is more than one primary acid-base disturbance. An infant with bronchopulmonary dysplasia may have a respiratory acidosis from chronic lung disease and a metabolic alkalosis from a diuretic used to treat the chronic lung disease. Formulas are available for calculating the appropriate metabolic or respiratory compensation for the six primary simple acid-base disorders. Appropriate compensation is expected in a simple disorder; it is not optional. If a patient does not have appropriate compensation, a mixed acid-base disorder is present.
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METABOLIC ACIDOSIS Metabolic acidosis occurs frequently in hospitalized children; diarrhea is the most common cause. For a patient with an unknown medical problem, the presence of a metabolic acidosis is often helpful diagnostically because it suggests a relatively narrow differential diagnosis.
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Causes of Metabolic Acidosis NORMAL ANION GAP Diarrhea Renal tubular acidosis Urinary tract diversions Posthypocapnia Ammonium chloride intake INCREASED ANION GAP Lactic acidosis (shock) Ketoacidosis (diabetic, starvation, or alcoholic) Kidney failure Poisoning (e.g., ethylene glycol, methanol, or salicylates) Inborn errors of metabolism
Slide 14-

Diarrhea Diarrhea causes a loss of bicarbonate from the body. The amount of bicarbonate lost in the stool depends on the volume of diarrhea and the bicarbonate concentration of the stool, which tends to increase with more severe diarrhea. Diarrhea often causes volume depletion because of Iosses of sodium and water, potentially exacerbating the acidosis by causing hypoperfusion (shock) and a lactic acidosis.
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RTA There are three forms of renal tubular acidosis (RTA): Distal (type I) Proximal (type II) Hyperkalemic (type IV)
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In distal RTA, children may have accompanying hypokalemia, hypercalciuria, nephrolithiasis, and nephrocalcinosis; rickets is a less common finding. Failure to thrive, resulting from chronic metabolic acidosis, is the most common presenting complaint. Autosomal dominant and autosomal recessive forms of distal RTA exist. The autosomal dominant form is relatively mild. Autosomal recessive distal RTA is more severe and often associated with deafness secondary to a defect in the gene for a H+-ATPase that is present in the kidney and the inner ear.
Slide 17-

Distal RTA also may be secondary to medications or congenital or acquired renal disease. Patients with distal RTA cannot acidify their urine and have a urine pH greater than 5.5, despite a metabolic acidosis.
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Proximal RTA is rarely present in isolation. In most patients, proximal RTA is part of Fanconi syndrome, a generalized dysfunction of the proximal tubule. Along with renal wasting of bicarbonate,Fanconi syndrome causes glycosuria , aminoaciduria , and excessive urinary losses of phosphate and uric acide.
Slide 19-

The chronic hypophosphatemia is more clinically significant because it ultimately leads to rickets in children. Rickets or failure to thrive may be the presenting complaint. Fanconi syndrome is rarely an isolated genetic disorder, with pediatric cases usually secondary to an underlying genetic disorder, most commonly cystinosis. Toxic medications, such as ifosfamide or valproate, may cause Fanconi syndrome. The ability to acidify the urine is intact in proximal RTA, and untreated patients have a urine pH less than 5.5. However, bicarbonate therapy increases bicarbonate losses in the urine, and the urine pH increases.
Slide 20-

In hyperkalemic RTA, renal excretion of acid and potassium is impaired due to either an absence of aldosterone or an inability of the kidney to respond to aldosterone.
Slide 21-

Lactic acidosis most commonly occurs when inadequate oxygen delivery to the tissues leads to anaerobic metabolism and excess production of lactic acid. Lactic acidosis may be secondary to shock, severe anemia, or hypoxemia. Inborn errors of carbohydrate metabolism produce a severe lactic acidosis. Diabetes mellitus Renal failure
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A variety of toxic ingestions cause a metabolic acidosis. Acute salicylate intoxication Ethylene glycole Methanol
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Clinical manifestation The underlying disorder usually produces most of the signs and symptoms in children with a mild or moderate metabolic acidosis. The clinical manifesrations of the acidosis are related to the degree of acidemia; patients with appropriate respiratory compensation and less severe acidemia have fewer manifestations than patients with a concomitant respiratory acidosis.
Slide 24-

At a serum pH less than 7.20, there is impaired cardiac contractility and an increased risk of arrhythmias, especially if underlying heart disease or other predisposing electrolyte disorders are present. With acidemia there is a decrease in the cardiovascular response to catecholamines ,potentially exacerbating hypotension in children with volume depletion or shock.
Slide 25-

Acidemia causes vasoconstriction of the pulmonary vasculature, which is especially problematic in newborns with persistent fetal circulation. The normal respiratory response to metabolic acidosis-compensatory hyperventilation-may be subtle with mild metabolic acidosis, but it causes discernible increased respiratory effort with worsening acidemia. Chronic metabolic acidosis causes failure to thrive.
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Diagnosis The plasma anion gap is useful for evaluating patients with a metabolic acidosis. It divides patients into two diagnostic groups: normal anion gap and increased anion gap. The following formula determines the anion gap: Anion gap: Na - cl - HCO3
Slide 27-

A normal anion gap is 3 to 11. A decrease in the albumin concentration of 1 g/dL decreases the anion gap by roughly 4 mEq/L. Similarly, albeit less commonly, an increase in unmeasured cations, such as calcium, potassium, or magnesium, decreases the anion gap. Conversely , a decrease in unmeasured cations is a rare cause of an increased anion gap.
Slide 28-

Treatment The most effective therapeutic approach for patients with a metabolic acidosis is correction of the underlying disorder, if possible. The administration of insulin in diabetic ketoacidosis or restoration of adequate perfusion in lactic acidosis eventually results in normalization of acid-base balance. The use of bicarbonate therapy is indicated when the underlying disorder is irreparable; examples include RTA and chronic renal failure.
Slide 29-

METABOLIC ALCALOSIS The causes of a metabolic alkalosis are divided into rwo categories based on the urinary chloride. The alkalosis in patients with a low urinary chloride is maintained by volume depletion. They are called chloride responsive because volume repletion with fluid containing sodium chloride and potassium chloride is necessary to correct the metabolic alkalosis. Emesis, which causes loss of hydrochloride and volume depletion, is the most common cause of a metabolic alkalosis.
Slide 30-

CHLORIDE RESPONSIVE (URTNARYCHLORTDE <15 MEQ/L) Gastric losses (emesis or nasogastric suction) Pyloric stenosis Diuretics (loop or thiazide) Chloride-losing diarrhea Chloride-deficient formula Cystic fibrosis (sweat losses of chloride) Posthypercapnia (chloride loss during respiratory acidosis)
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CHLORIDE RESISTANT(URINARY CHLORIDE> 2O MEQ/L) High blood pressure Adrenal adenoma or hyperplasia Glucocorticoid-remediable aldosteronism Renovascular disease Renin-secreting tumor l7Alfa-Hydroxylase deficiency 11Beta-Hydroxylase deficiency Cushing syndrome 1 1 Beta-Hydrorysteroid dehydrogenase deficiency Licorice ingestion Liddle syndrome Normd blood pressure Gitelman syndrome Bartter syndrome Base administration
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Clinical Manifestation The symptoms in patients with a metabolic alkalosis often are related to the underlying disease and associated electrolyte disturbances. Hypokalemia is often present, and occasionally severe in all the diseases that cause a metabolic alkalosis.
Slide 33-

Children with chloride responsive causes of metabolic alkalosis often have symptoms related to volume depletion. In contrast, children with chloride-unresponsive causes may have symptoms related to hypertension. Alkalemia may cause arrhythmias, hypoxia secondary to hypoventilation, or decreased cardiac output.
Slide 34-

Diagnosis Measurement of the urinary chloride concentration is the most helpful test in differentiating among the causes of a metabolic alkalosis. The history usually suggests a diagnosis, although no obvious explanation may be present in the patient with bulimia, surreptitious diuretic use, or an undiagnosed genetic disorder, such as Bartter syndrome or Gitelman syndrome.
Slide 35-

Treatment The approach to therapy of metabolic alkalosis depends on the severity of the alkalosis and the underlying etiology. In children with a mild metabolic alkalosis (HCO3<32mEq/Lit), intervention is often unnecessary.
Slide 36-

Patients with chloride – responsive metabolic alkalosis respond to correction of hypokalemia and volume repletion with sodium and potassium chloride, but aggressive volume repletion may be contraindicated if mild volume depletion is medically necessary in the child receiving diuretic therapy.
Slide 37-

In children with chloride-resistant causes of a metabolic alkalosis that are associated with hypertension, volume repletion is contraindicated because it exacerbates the hypertension and does not repair the metabolic alkalosis. Treatment focuses on eliminating or blocking the action of the excess mineralocorticoid. In children with Bartter syndrome or Gitelman syndrome, therapy includes oral potassium supplementation and potassium-sparing diuretics.
Slide 38-

RESPIRATORY ACID- BASE DISTURBANCES During a respiratory acidosis,there is a decrease in the effectiveness of CO2 removal by the lungs. The causes of a respiratory acidosis are either pulmonary or nonpulmonary.
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Causes of Respiratory Acidosis Central nervous system depression (encephalitis or narcotic overdose) Disorders of the spinal cord, peripheral nerves, or neuromuscular junction (botulism or Guillain-Barre syndrome) Respiratory muscle weakness (muscular dysrrophy) Pulmonary disease (pneumonia or aschma) Upper airway disease (laryngospasm)
Slide 40-

A respirarory alkalosis is an inappropriate reduction in the blood CO2 concentration. A variety of stimuli can increase the ventilatory drive and cause a respiratory alkalosis.
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Causes of Respiratory Alkalosis Hypoxemia or tissue hypoxia (carbon monoxide poisoning or cyanotic heart disease) Lung receptor stimulation (pneumonia or pulmonary embolism) Central stimulation (anxiety or brain tumor) Mechanical ventilation Hyperammonemias
Slide 42-

Treatment of respiratory acid-base disorders focuses on correction of the underlying disorder. Mechanical ventilation may be necessary in a child with a refractory respiratory acidosis.