Download Medical Notes on OncomiR or Tumor Suppressor-The Duplicity of MicroRNAs in Cancer

OncomiR or Tumor Suppressor-The Duplicity of MicroRNAs in Cancer Medical Notes

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Description:MicroRNAs (miRNA) are short, noncoding RNAs whose dysregulation has been implicated in most, if not all, cancers. They regulate gene expression by suppressing mRNA translation and reducing mRNA stability. To this end, there is a great deal of interest in modifying miRNA expression levels for the treatment of cancer. However, the literature is fraught with inconsistent accounts as to whether various miRNAs are oncogenic or tumor suppressive. In this review, we directly examine these inconsistencies and propose several mechanisms to explain them. These mechanisms include the possibility that specific miRNAs can simultaneously produce competing oncogenic and tumor suppressive effects by suppressing both tumor suppressive mRNAs and oncogenic mRNAs, respectively. In addition, miRNAs can modulate tumor-modifying extrinsic factors, such as cancer-immune system interactions, strom

Tags:MicroRNAs,MicroRNAs in Cancer,Cancer

Published on: Apr 18, 2022 | Views : 1456 | Downloads : 2