Download Free Medical WHAT IS NEW IN HEAD AND NECK CANCERS PowerPoint Presentation

WHAT IS NEW IN HEAD AND NECK CANCERS PowerPoint Presentation

DOWNLOAD MEDICAL POWERPOINT PRESENTATION

About This Presentation

Description : Check out this medical presentation on Pathology, which is titled "WHAT IS NEW IN HEAD AND NECK CANCERS?", to know about the new developments in head and neck cancers.

Tags : Pathology, developments, head, neck cancers

Published on : Aug 06, 2021 | Views : 3225 | Downloads : 1

Shareable Url :

Embed Code :

Comment

Transcript

Slide 1-

Oral Cancer Professor Ravi Kant MS, DNB, FRCS (Edin.) ,FRCS( Glasg.), FACS , FICS, MNAMS,
Slide 2-

WHAT IS NEW IN HEAD AND NECK CANCERS? Dr. K.A.Pathak, MS, Dip NB, FRCS, FRCSEd. Associate Professor in Head & Neck Oncology Tata Memorial Hospital, Mumbai
Slide 3-

New Molecular Model Califano et al , Cancer Research 1996
Slide 4-

What is New in Imaging? Ultrasonography and Guided FNAC Real time Inexpensive Quicker but operator dependent Doppler can show flow characteristics CT Scan with 3 D views Virtual Laryngoscopy
Slide 5-

CT Scan with 3 D views
Slide 6-

Virtual Laryngoscopy
Slide 7-

MRI and MR Angiography
Slide 8-

Residual / recurrent locoregional disease Detection of occult primaries in MUO Occult metastatic disease in the neck Synchronous primaries or metastasis 18FDG-PET
Slide 9-

What is New in Staging ? T4 lesions have been divided into T4a (resectable) and T4b (unresectable) Stage IVA T4a N0 M0 T4a N1 M0 T1-4a N2 M0 Stage IVB T4b Any N M0 Any T N3 M0 Stage IVC Any T Any N M1 (AJCC 6th Ed, 2000)
Slide 10-

What is New in Surgery? Oral cavity: Pattern of Mandibular invasion Mandible Preservation Larynx: Endoscopic Laser Excision Conservative laryngectomy Primary voice rehabilitation PNS Tumors: Endoscopic Sinus Surgery Cranio-facial Excision
Slide 11-

ppt slide no 11 content not found
Slide 12-

What is New in Chemotherapy ? Category Hazard ratio CT effect Abs. benefit (p) 2yrs 5yrs Adjuvant 0.98 0.74 1% 1% Neo-adjuvant 0.95 0.10 2% 2% Concomitant 0.81 <0.0001 7% 8% Total 0.90 <0.0001 4% 4% MACH-NC, LANCET 2000
Slide 13-

Laryngeal Preservation VALCSG 1991 Larynx preserved in 64% patients No change in overall survival EORTC 1996 42% functioning larynx-3 yrs, 35% -5 yrs RTOG 2003 88% functioning larynx at 2 years 22% loco- regional failures
Slide 14-

What is New in Radiotherapy ? Techniques Alt. Fractionation- Accelerated & Hyperfr. 3D Conformal Radiotherapy & IMRT Stereotactic/ Fr. Stereotactic Radiothearpy Neutron Beam/Charged Particle RT Intraoperative Radiotherapy Radiation Induced Xerostomia Pharmacological Agents- Amifostin, GMCSF Submandibular Gland Transfer (Seikaly et al)
Slide 15-

ppt slide no 15 content not found
Slide 16-

Newer Targets of Therapy Photodynamic Therapy: Palliation Curative intent- Small primary tumor Second primary/ Recurrent tumor Premalignant lesions Antibody based Therapy Monoclonal Ab against EGFr-C225 Inhibitors of EGFr-ZD1839, Erlotinib HCl Gene Therapy
Slide 17-

Gene Therapy- Approaches Augmentation therapy Immunotherapy: Cytokine gene transfer- IL-2,IL-12, IFN- g Vaccination Tumor specific antigen Co-stimulator molecule Foreign antigen Chemotherapy: HSV TK Drug sensitization / Drug resistance Gene replacement Replace tumor suppressor gene- p53 Inhibit an oncogene- Antisense c DNA Adjuvant Therapy- Post CT / RT/ Surgery
Slide 18-

Chemoprevention Possible Roles Reversal of oral pre-cancerous lesions Chemoprevention of SPT Primary chemoprevention in high-risk Phamacological Agents Beta Carotene Retinoids- 13cRA,Vitamin A Retinamides a-tocopherol
Slide 19-

Thank You!
Slide 20-

Overview Molecular Basis of Carcinogenesis Imaging- 3-D CT , MR Angio, FDG-PET Staging- Changes in TNM (6th Ed. AJCC) Concurrent Chemo- RT- MACH- NC, RTOG Advances in Radiotherapy Techniques Improved Quality of Life- Post Surgery/RT Newer Targets for therapy Advances in Chemoprevention