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Using Bioinformatics-Genetic Research PowerPoint Presentation

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Description : Check out this medical titled "Using Bioinformatics: Genetic Research”.

This medical tells us how bioinformatics is an important tool in genetic research and allows researchers to analyze vast amounts of genetic data quickly and accurately.

Here are some ways in which bioinformatics is used in genetic research:

Genome Sequencing: Bioinformatics tools are used to analyze large volumes of data generated from genome sequencing experiments. This includes the assembly and annotation of the genome, identification of genetic variants and mutations, and understanding the functions of genes.

Functional Genomics: Bioinformatics is used to study the functions of genes and their interactions with other genes, proteins, and biological processes. This includes analyzing gene expression patterns, identifying regulatory elements, and predicting protein-protein interactions.

Comparative Genomics: Bioinformatics tools are used to compare and analyze the genomes of different organisms to identify similarities and differences. This allows researchers to understand the evolution of genes and biological processes across different species.

Pharmacogenomics: Bioinformatics is used to study how genetic variation affects drug response in individuals. This includes identifying genetic markers that can predict drug response and developing personalized medicine approaches.

Proteomics: Bioinformatics is used to analyze large-scale data generated from proteomics experiments. This includes identifying protein-protein interactions, post-translational modifications, and predicting protein structures.

Tags : Bioinformatics, Genetic Research, Genome Sequencing, Functional Genomics, Comparative Genomics, Pharmacogenomics, Proteomics, Medical Genetics, Medical Genetics

Published on : Jun 01, 2023 | Views : 1510 | Downloads : 1

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Slide 1-

LESSON 1: What is Genetic Research? PowerPoint slides to accompany Using Bioinformatics: Genetic Research
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Genetic Research Deals with Inherited Traits DNA isolation. Use bioinformatics to research differences in DNA sequences. Genetic researchers study inherited traits by analyzing DNA sequences. How are we similar? How are we different?
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Scientific Practices Ask a Question Based on Observations: Plants grow in soil. What do plants use to grow larger? Hypothesis & Prediction: If – and – then Hypothesis: Plants use materials in the soil to gain mass. Prediction: If my hypothesis is correct, and I measure the mass of soil & plants over time, then I predict the soil mass will decrease as plant mass increases. Gather and Analyze Data (Methods): Measure mass of bean seeds and soil at Day 1 and Day 15. Results: Bean plants increased in mass by 24.6 grams. Soil mass stayed the same. Conclusions: Minerals from the soil do not affect the mass of plants. Hypothesis is contradicted. New Hypothesis: Plants use something in the air to gain mass. Image Source: Wikipedia Commons
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The Practices of Scientific Research Hypothesis and Prediction Data Collection and Analysis Interpretation and Evaluation Observations of Nature
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What is Bioinformatics? Bioinformatics is the application of computer science and information technology to biology and medicine. Bioinformatics makes it possible to analyze large quantities of complex biological data and can be used to search biological databases, compare sequences, and draw molecular structures.
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Bioinformatics Tools Help Scientists:Organize, Process, and Make Sense of Complex Biological Data Sets Protein Bioinformatics Tools: DNA Sequencing Identify Mutations in DNA. DNA RNA Bioinformatics Tools: RNA Sequencing Identify tissue specific gene expression. Bioinformatics Tools: Protein 3D Structure visualization. Question: What kinds of scientific questions can we answer with bioinformatics tools? Image Source: Wikipedia Commons
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The Practices of Scientific Research Hypothesis and Prediction Data Collection and Analysis Interpretation and Evaluation Observations of Nature DNA sequences from tumors contain genetic mutations. Genetic differences contribute to the development of cancer. Comparisons of genomes from different cancers identify variants in genes X and Y. Studies by other scientists demonstrate that genes X and Y are involved in DNA repair, which could explain the increased cancer risk. Do families with higher rates of cancer also have higher rates of DNA damage?
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DNA Sequencing Core Lab ManagerELLEN SISK, MS Place of Employment: Seattle Biomedical Research Institute Type of Work: Manages the DNA Sequencing “Core.” The Core lab is a centralized facility that provides DNA sequencing for all the researchers at the Institute. The Seattle BioMed Sequencing Core facility has been in operation for over 18 years and offers DNA sequencing and analysis to Seattle's scientific community, as well as international scientists and organizations. Our service provides cost-effective solutions for small laboratories that lack access to sequencing technology.
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Which Animals are Most Closely Related to One Another? Gray wolf Jack Russell Toy Poodle Labradoodle Coyote English Shepherd Cocker Spaniel Red fox Image Source: Wikipedia Commons
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Reference …TTCACCAACATGCCCACA… F T N M P T Patient …TTCACCAACAGGCCCACA… F T N R P T …TTCACCAACAGGCCCACA… Extract DNA from Cells. Sequence DNA. Compare Patient DNA Sequence to Reference Sequence. Search Database to Determine if Patient Mutation is Associated with Disease. Patient Sample: Blood or Saliva. Inside the Gene Machine: How Information from DNA is Acquired and Used for Genetic Testing Genetic Counselors work with patients to help them decide whether or not to have a genetic test, and help them understand the results of the test. Lab Technicians work with patient samples in the lab, purifying and sequencing the DNA. Bioinformatics programmers create computer programs to help biologists analyze data. Biomedical Researchers perform experiments with patient samples to find different variations of genes that might cause disease. Bioinformatics tools like BLAST and ClustalW are used to compare sequences. Medical Doctors and Veterinarians use the knowledge gained from genetic testing to care for their patients. Image Source: Microsoft Clip Art
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How DNA Sequence Data is Obtained for Genetic Research Genetic Data …TTCACCAACAGGCCCACA… Extract DNA from Cells. Sequence DNA. Compare DNA Sequences to One Another. Obtain Samples: Blood , Saliva, Hair Follicles, Feathers, Scales. TTCAACAACAGGCCCAC TTCACCAACAGGCCCAC TTCATCAACAGGCCCAC Image Source: Wikipedia Commons
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Which Animals are Most Closely Related to One Another? Gray wolf Jack Russell Toy Poodle Labradoodle Coyote English Shepherd Cocker Spaniel Red fox Image Source: Wikipedia Commons
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Multiple Sequence Alignment of Canine DNA Sequences
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Color Coding Reveals Differences
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DNA Sequencing Core Lab ManagerELLEN SISK, MS Place of Employment: Seattle Biomedical Research Institute Type of Work: Manages the DNA Sequencing “Core.” The Core lab is a centralized facility that provides DNA sequencing for all the researchers at the Institute. The Seattle BioMed Sequencing Core facility has been in operation for over 18 years and offers DNA sequencing and analysis to Seattle's scientific community, as well as international scientists and organizations. Our service provides cost-effective solutions for small laboratories that lack access to sequencing technology.
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CAREERS IN SPOTLIGHT:DNA Sequencing Core Lab Manager What do they do? The manager oversees the core lab facility. These types of facilities make it possible to perform DNA sequencing reactions and analysis for many different researchers at a given institution, company, or university. The Core lab facility makes it possible for many researchers to share the same DNA sequencing facility and expertise of technicians and the Core Lab Manager. What kind of training is involved? Bachelor’s degree in biology, molecular biology, biochemistry, or related discipline. Some have a Master’s degree or a PhD. What is a typical salary for a Core Manager? Salaries vary with experience and range from $50-$100,000 per year ($25-$50/hour). Source: Genome Technology Salary Survey 2010