Download Free Medical Thyroid Disorders PowerPoint Presentation

Thyroid Disorders PowerPoint Presentation

DOWNLOAD MEDICAL POWERPOINT PRESENTATION

About This Presentation

Description : Produces, stores, and releases metabolically active hormones

Tags : Thyroids,Thyroids disorder

Published on : Dec 14, 2023 | Views : 686 | Downloads : 1

Shareable Url :

Embed Code :

Comment

Transcript

Slide 1-

Thyroid Disorders Mikael Jones, Pharm.D., BCPS Assistant Professor University of Kentucky College of Pharmacy
Slide 2-

Thyroid Gland Produces, stores, and releases metabolically active hormones Maintains metabolic stability Maintains growth and development Maintains body temperature and energy use
Slide 3-

Thyroid Gland
Slide 4-

Thyroid Hormones
Slide 5-

Thyroid Hormones
Slide 6-

Thyroid Hormones
Slide 7-

Hypothalamus-Pituitary-Thyroid axis Hypothalamus Anterior Pituitary Gland Thyroid Gland Target Organs TRH TSH T3/T4    T3/T4 binds to thyroid hormone receptors which regulates the transcription of genes   
Slide 8-

FT4/ FT3 + Low TSH Normal TSH Range FT4 w/in range Low FT4 + Elevated TSH FT4 w/in range + TPOab Overt Hyperthyroidism Overt Hypothyroidism Subclinical Hyperthyroidism Subclinical Hypothyroidism 1 4.5 10 100 0.4 0.1 0.01 TSH U/L TSH and Spectrum of Thyroid Disorders
Slide 9-

Hyperthyroidism
Slide 10-

Clinical Presentation
Slide 11-

Clinical Presentation
Slide 12-

Hypothyroidism
Slide 13-

Clinical Presentation
Slide 14-

ppt slide no 14 content not found
Slide 15-

Subclinical Thyroid Disease Controversial on when to treat Patients have few to no symptoms of thyroid dysfunction Subclinical Hypothyroid TSH >4.5 mIU/L Free T4 =WNL (0.8-1.5 ng/dL) Subclinical Hyperthyroid TSH below the reference range Free T4 and T3 = WNL
Slide 16-

Subclinical Thyroid Disease Subclinical Hypothyroidism Typically do not treat Consider treatment if Pregnant or considering pregnancy TSH >7-10 mIU/L Increased risk for CHF in elderly Increased risk in developing hypothyroid Elderly Clinical sxs present Subclinical Hyperthyroidism Typically treat if patient has TSH <0.1 mIU/L and any of the following Heart disease (CHF, A-fib, arrhythmias) Osteoporosis Age >60 Typically monitor patient if TSH 0.1-0.45 mIU/L
Slide 17-

Euthyroid Sick Syndrome Nonthyroidal Illness Acute and Chronic Illness can decrease T3 concentrations TSH will not change Decrease in T4 to T3 conversion Possible body adaptation Do not treat unless true hyperthyroidism is present
Slide 18-

Myxedema Coma End stage of long-standing, uncorrected hypothyroidism Clinical s/sxs Hypothermia Advanced hypothyroid symptoms Altered sensorium Delirium to coma High Mortality
Slide 19-

Myxedema Coma Treatment Thyroxine 300-500 mcg IV bolus 75-100 mcg IV daily Hydrocortisone 100mg IV q8h until adrenal suppression is ruled out Supportive Therapy Maintain ventilation, euglycemia, BP, and body temperature
Slide 20-

Thyroid Storm Life-threatening medical emergency Severe thyrotoxicosis High fever Tachycardia Tachypnea Dehydration Delirium Coma N/V/D Precipitating Factors Infection Trauma Surgery RAI treatment Withdrawal of antithyroid drugs Occurs at any age Average duration 72 hours with treatment Mortality 20%
Slide 21-

Thyroid Storm Therapeutic Measures Suppression of thyroid hormone formation and secretion Antiadrenergic activity Corticosteroids Treatment of complications or coexisting factors that may have precipitated the storm PTU is preferred 900-1200mg/day Can be given rectally or through NG tube Iodides Give after PTU Propranolol 40-80mg q6h Esmolol if cardiac disease or risk of pulmonary disease or cardiac failure No NSAIDS or aspirin APAP to treat fever