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Renal Disease: Overview and Acute Renal Failure PowerPoint Presentation

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Description : This medical presentation on cancer titled "Renal Disease: Overview and Acute Renal Failure" provides information on kidney sites susceptible to renal disease, its categorization, glomerular capillary (normal versus pathology), nephrotic versus nephritic disorders, and acute renal failure.

Tags : Cancer, Renal Disease, Overview, Acute Renal Failure, kidney, categorization, glomerular capillary, normal, pathology, nephrotic, nephritic, disorder, disorders

Published on : Apr 28, 2021 | Views : 1982 | Downloads : 6

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Slide 1-

RENAL DISEASE: OVERVIEW AND ACUTE RENAL FAILURE Pathophysiology of Disease: Chapter 16 (388-394) Jack DeRuiter, PhD Department of Pharmacal Sciences
Slide 2-

Kidney Sites Susceptible to Renal Disease (page 388) General: Renal medulla: Low oxygen environment: Ischemia Glomerulus: Structure predisposes it to immune complex deposition and complement fixation Tubules: “Post-Renal” Structures (ureters, bladder) Malformations, Obstruction, Masses (i.e. cancer)
Slide 3-

CATEGORIZATION Generalized Site of Disease: Prerenal: Inadequate renal blood flow Intrarenal: Nephron damae Postrenal: Obstruction, Structural defects Site of Renal Lesion (Intrarenal) Glomerulopathy Nephritic: Nephrotic: Tubulointerstitial Disease Etiologic Factors: Infection, Diabetes, etc.
Slide 4-

Glomerular Capillary: Normal versus Pathology
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Glomerular Capillary Pathology (see previous slide) 1. Membranous nephropathy: Subepithelial deposits 2. Post-infectious glomerulonephritis: Subepithelial 3. Lupus glomerulonephritis: Subendothelial deposits 4. IgA Nephropathy: Mesangial deposits 5. Goodpasture’s Syndrome: Antibody binding to GBM 6. Glomerular injury with proteinuria: Podocyte effacement
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Nephrotic vs Nephritic Disorders Nephrotic: profound proteinuria Immune complex deposits: Epithelial NO cellular inflammatory reaction Nephritic: Variable proteinuria Immune complex deposits: Subendothelial or GBM Cellular inflammatory reaction
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ACUTE RENAL FAILURE: Clinical Presentation (pages 389-390) Heterogeneous group of disorders characterized by rapid deterioration in renal function (Decreased GFR) Rapid elevation of BUN and serum creatinine Oliguria: Variable Other: Henaturia, proteinuria, edema, hypertension
Slide 8-

ACUTE RENAL FAILURE: Etiology (page 390 and Table 16-3) Prerenal: CV and volume depletion Drug-induced or related (NSAIDs, ACEIs, diuretics) Intrarenal: Inflammatory disease: Vasculitis, glomerulo-nephritis, drug-induced Acute tubular necrosis Postrenal: Obstruction, Cancer, congenital abnormalities
Slide 9-

ACUTE RENAL FAILURE: Pathology (pages 390-392) Acute tubular necrosis (ATN): Tubular cell sloughing Reversibility/Irreversibility: Dependent on time of intervention ATN Pathogenesis Tubular occlusion theory and cast formation Vascular hypoperfusion theory: Afferent vasoconstriction with Efferent vasodilation Role of renal mediators?
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ACUTE RENAL FAILURE: Early Clinical Manifestations (pages 392-394) Symptoms depend on degree and cause of renal failure (See Table 16-5) Initial Symptoms: Fatigue and malaise: Loss of excretory capacity and accumulation of water, electrolytes and nitrogenous wastes Prerenal azotemia: Elevated BUN/SrCr (20-30:1) with normal SrCr Urinalysis: No casts detected Maximal urinary concentration: 1500 mosm/L Fractional Na Excretion (99%) May progress to ATN without proper treatment
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ACUTE RENAL FAILURE: Later Clinical Manifestations (pages 392-394) Later Symptoms (frank ATN): dyspnea, orthopnea, heart (sound S3), edema Normal BUN/SrCr, profressive elevation of SrCr Casts (protein, RBC, epithelial cells) Urine osmolality Fractional excretion of Na (as low as 1%)