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Precision Medicine Initiative - Background PowerPoint Presentation

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Description : Check out this medical presentation on Precision Medicine, which is titled "Precision Medicine Initiative - Background", to know about a new era of medicine through research, technology, and polices that empower patients, researchers, and providers to work together toward development of individualized treatments.

Tags : Precision Medicine, research, technology, individualized treatments

Published on : Jul 20, 2021 | Views : 3592 | Downloads : 1

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Mission: To enable a new era of medicine through research, technology, and polices that empower patients, researchers, and providers to work together toward development of individualized treatments. Precision Medicine Initiative - Background PMI Cohort Program (PMI-CP) WG: Vision and Design for a longitudinal research cohort of ≥1 million volunteers Key Questions: 1) Combine existing cohorts, establish new, or both? 2) How to capture the U.S. population diversity? 3) What data types should be included? 4) What policies needed for maximal benefit to all stakeholders? Information Input: 4 Workshops between April and July 2015 –Unique Scientific Opportunities for the National Research Cohort – Digital Health Data in a Million-Person Precision Medicine Initiative – Participant Engagement and Health Equity – Mobile and Personal Technologies in Precision Medicine Requests for Information – Building the cohort – Strategies to address community engagement and health disparities FNIH Survey of public perceptions of precision medicine cohort White House Privacy and Trust Principles
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Scientific Opportunities Discover new biomarkers predictive of future disease risk Discover determinants of individual variation in response to therapeutics Determine quantitative risk estimates in the population by integrating environmental exposures, genetic factors, and gene-environment interactions Integrate mHealth and sensor technologies Determine clinical impact of loss-of-function mutations on clinical outcome Discover new classifications and relationships among diseases Enable targeted clinical trials of subjects with rich clinical data Make ‘big data’ broadly available to investigators
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PMI Cohort Answer to Key Question 1 : Establish New Cohort One million or more volunteers: – Recontactable – Collect EHR data, provide biospecimen, survey, and complete a baseline exam Longitudinal cohort, with continuing interactions, recontactable for secondary studies Two methods of recruitment – Direct volunteers - Anyone can sign up – Healthcare provider organizations (incl. FQHCs) : HPO choice depends on diversity, EHR robustness, and patient follow-up
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PMI Cohort Answer to Key Question 2 : Diversity Sources Groups that are underrepresented All states of health and disease All areas of the U.S. All life-stages Special policy considerations – enrolling children – decisionally impaired – participants who become incarcerated
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Information Flow In Information Flow Out
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Informatics Opportunities: Information Flow Between the CC and Sites
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Initial Core Data Set – Informatics Opportunities
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Next Steps Principles: Utilize innovative ways to implement the cohort Stay flexible, nimble, cutting edge Priorities: Act quickly to bring in a PMI Director & to “staff up” Quickly build infrastructure to support enrollment – Communications & engagement – Single IRB and consent – Data storage & acquisition infrastructure – Biobank Begin enrollment ASAP