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Pharmacogenomics PowerPoint Presentation

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Description : Check out this medical PowerPoint presentation titled "Pharmacogenomics" by Rita Leone, RN, MSN, CMSRN.
This medical PowerPoint presentation talks about Pharmacogenomics is the study of how genetic variations can affect an individuals response to drugs. It combines the fields of pharmacology and genomics to understand how an individuals genetic makeup can impact their ability to metabolize drugs, their susceptibility to side effects, and their overall response to treatment.
By analyzing an individuals genetic profile, healthcare providers can tailor drug therapies to maximize efficacy and minimize adverse effects. Pharmacogenomics has the potential to revolutionize the way drugs are prescribed, making treatments more precise and personalized.
The field of pharmacogenomics is rapidly advancing, and its application has already resulted in significant improvements in patient care. For example, pharmacogenomic testing is now used to determine the appropriate dosage of drugs used in the treatment of cancer, HIV, and mental health conditions. Additionally, the US Food and Drug Administration (FDA) now requires pharmacogenomic testing for certain drugs before they are prescribed.

Tags : Pharmacogenomics, genetic variations, pharmacology, genomics, Genetics, Genetics PowerPoint presentation

Published on : Mar 27, 2023 | Views : 2013 | Downloads : 7

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Slide 1-

Pharmacogenomics Rita Leone, RN, MSN, CMSRN
Slide 2-

Objectives Define Pharmacogenomics/Pharmacogenetics Describe how genetics is used to tailor drug therapies Discuss the RN’s role (r/t pharmacogenomics) Identify barriers to integrating pharmacogenomics into practice Explore current pharmacogenetic testing that affects selection/dosing of drug therapies (Warfarin/Coumadin & Trastuzumab/Herceptin)
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What is Pharmacogenomics? Pharmacogenomics is a rapidly growing field of research into the ways in which genetic variation affects drug response Identifying genetic markers for differences in the way people metabolize drugs Developing genetic tests that predict how individual patients will respond to drugs (i.e. statins, cancer therapies). Goal… To develop precisely targeted, optimal drug therapy Minimizing drug related adverse events
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Pharmacogenetics: Your Doctors New Genetic Tools http://learn.genetics.utah.edu/content/health/pharma/intro/
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Pharmacogenomics: Role of the RN Explaining rationale for genetic testing Provide appropriate patient teaching regarding drug selection Understand drug dosing variances between patients
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Barriers Who pays for the genetic testing if not already standard of care? FDA Insurers (i.e. KRAS) Professional Organizations
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Warfarin (Coumadin): Factors Affecting Dose/Response Age Increased age = decreased dose Height and Weight taller and/or weight more = higher warfarin dose Ethnicity Ancestry plays an important role Asians: may need lower doses than Caucasians African Americans: may need higher doses. Diet Warfarin works by inhibiting vitamin K. consuming large amounts of vitamin K (through foods or supplements) = higher warfarin doses. Other Medications, Herbs, or Supplements Many prescription and over-the-counter medications interact with warfarin. Inform prescribing physician of all medications, herbs, & supplements taking Other Health Conditions Some diseases affect how our bodies respond to medications
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2 more…introducing the CYP2C9 and VKORC1 Genotypes 1) CYP2C9 gene variant Instructs body how to make an enzyme that metabolizes warfarin—an enzyme converts one chemical to another Changes in the CYP2C9 gene can your ability to metabolize or clear warfarin from the body When the body cannot metabolize warfarin at the usual rate, drug level builds up to a potential overdose People with these CYP2C9 variants generally need warfarin doses. 2) VKORC1 gene variant Contains instructions for making an enzyme called vitamin K epoxide reductase, (or VKOR) which plays an important part in making blood-clotting factors. Warfarin stops blood clots by decreasing the effectiveness of VKOR=lowering the amount of VKOR produced Since people with this gene variant have enzyme levels to start with, taking an average warfarin dose may their blood clotting factors too much--putting them at a higher risk for adverse events (bleeding)
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HER2 + Breast Cancer: Target Therapies Affecting Tumor Growth Aggressive form of breast CA Associated with genetic variation leading to overproduction of protein called HER2 Tumor samples tested for high levels of HER2 If yes…Herceptin (Trastuzumab) is indicated
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Using Genetics to Tailor Drug Therapy https://atlantichealth.dnadirect.com/grc/patient-site/warfarin-response/what-affects-warfarin-response.html
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Where are we at?
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To summarize…
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Thank you! Questions?