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Description : Check out this medical presentation on Skin Condition, which is titled "Oats in Skin Care", to know about the benefits of oats in skin care.

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Published on : Jul 05, 2021 | Views : 1912 | Downloads : 3

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Slide 1-

Oats in Skin Care USE OF OATS IN SKIN CARE
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Historic Perspectives on Oats Brown DJ, Dattner AM. Arch Dermatol. 1998;134(11):1401-1404. Baumann L. Skin & Allergy News. 2004;35:44-45. Kurtz ES, Wallo W. J Drugs Dermatol. 2007;6(2):167-170. Common or wild oat (Avena sativa) has a long history of traditional folk use, particularly in poultices or soaks The use of oats in skin care dates back to 2000 BC in Egypt and the Arabian peninsula Colloidal oatmeal acknowledged by the Food and Drug Administration (FDA) 1989: safe and effective (Category I ingredient) 2003: skin protectant monograph
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Attributes of Colloidal Oats in Skin Care
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avenanthramides
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Active Phytochemicals in Oats Eichenfield LF, et al. Cutis. 2007;80(6 suppl):2-16.
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Avenanthramides vs other oat fractions Vollhardt J, Fielder DA, Redmont MJ. Identification and cosmetic application of powerful anti-irritant constituents of oat grain. XXI IFSCC International Congress 2000, Berlin. Proceedings; 395-402. Separated oat fractions tested in a skin erythema model/Patients received 1.5 MED of UVB/Products applied 24 hours after irradiation/Clinical erythema evaluation 24 hours after product application % of redness attenuation per gram after UV irradiation. Measure 24h after application Avenanthramides Flavonoids Saponins 0 50 100 150 200 250 The avenanthramide fraction is the most effective oat component in reducing UV-induced redness 24 hours after dermal application
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Avananthramides Inhibit Topical Skin Irritation IL-8 Release (pg/mL) from Keratinocytes 150 180 210 240 270 Unstimulated Avenanthramide (μg/mL) Stimulated 1 10 100 IL-8=interleukin-8. Wallo W, et al. Poster presented at: 65th annual meeting of the AAD. February 2-6, 2007; Washington, DC.
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Antioxidant Properties Have Been Shown to Reduce Erythema The purified avenanthramide fractions were applied to a skin erythema model. Significant reduction in skin redness (P<0.05) 24 hours after application when applied in concentrations as low as 1.5 ppm Vollhardt J, Fielder DA, Redmont MJ. Identification and cosmetic application of powerful anti-irritant constituents of oat grain. XXI IFSCC International Congress 2000; Berlin. Proceedings; 395-402. Greatest activity against UV-induced skin erythema 24 hours after application
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Oat lipids
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Composition of Oat Lipids Total lipid content of oats: from 2%–11.8% dry weight Triglycerides Phospholipids Lecithin Glycolipids Free fatty acids Oleic, Linoleic, Palmitic, Stearic Zhou M, et al. J American Oil Chem Soc. 1999;76(2):159-169.
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Oat Oil Reduces TEWL Compared to Control Sites Potter RC et al. US Patent 5620692. April 15, 1997. TEWL=transepidermal water loss.
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Whole Oat Oil Lipid Class Composition Southall M, et al. The Dermatologist. September 2012 (suppl):1-4.
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Fatty Acid (%) Composition of Oat Oil Southall M, et al. The Dermatologist. September 2012 (suppl):1-4.
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Clinical Evidence Supporting the Use of Oat-Containing Products in Skin Care
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Skin Conditions Where Colloidal Oatmeal Has Been Shown Well Tolerated Kurtz ES, Wallo W. J Drugs Dermatol. 2007;6(2):167-170. Matheson JD, et al. J Burn Care Rehabil. 2001;22(1):76-81. Alexandrescu DT, et al. Clin Exp Dermatol. 2006;32(1):71-74. Talsania N, et al. Clin Exp Dermatol. 2007;33(1):97-108. *Shown in both children and adults.
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ECZEMA (N=33) SENILE SKIN WINTER ITCH SENILE PRURITUS PH NORMAL pH RANGE 4.2-5.5 pH LEVEL IMMEDIATELY AFTER TREATMENT WITH COLLOIDAL OATMEAL pH LEVEL BEFORE TREATMENT Grais M. AMA Arch Derm Syphilol.1953;68(4):402-407. pH measured on forearm (N=33) (N=16) (N=14) Buffering Capacity of Colloidal Oatmeal Restores the pH of Damaged Skin to Within the Normal Range
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Colloidal Oatmeal Cream vs Rx Barrier Emulsion for Improving Skin Barrier in Moderate-to-Severe Dry Skin -35 -15 -20 -30 4 -25 9 Days 1 7 Percent Mean Reduction in Water Loss Regression Period Colloidal Oatmeal Cream Rx Skin Barrier Emulsion Nebus J, et al. J Am Acad Dermatol. 2011;64:AB71.
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Oatmeal Lotion Use for Moderate-to-Severe Xerosis Transepidermal Water Loss (TEWL) Visual Dryness Nebus J, Schmalenberg K, Wallo W. The effectiveness of an oatmeal lotion in improving and maintaining barrier function and moisture levels of moderate to severe xerosis. P1608.
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*Colloidal oatmeal with ceramides and dexpanthenol. Wallo W, et al. Poster presented at: 65th annual meeting of the AAD; February 2–6, 2007; Washington DC. Colloidal Oatmeal Bath* in the Treatment of Dry and Sensitive Skin in Atopic Dermatitis 0 1.2 Before After Itching Burning Grading Score 0.2 0.6 1.0 0.4 0.8 4-week, investigator-blinded, crossover study (N=25) 50% 67%
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Daily Oat-Based Skin Care Regimen for Atopic Skin: IGA and Itch Severity Dermatologist Assessment: IGA and Itch Severity (ages 12–60 years) *Significant improvement (P<0.01). IGA=Investigator’s Global Assessment. Fowler JF, et al. J Drugs Dermatol. 2012;11(7):804-807. * * * * * *
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Dermatologist Assessment: EASI Composite Score (ages 12–60 years) EASI=eczema area and severity index . *Significant improvement (P<0.001). Fowler JF, et al. J Drugs Dermatol. 2012;11(7):804-807. Daily Oat-based Skin Care Regimen for Atopic Skin: EASI Composite Score
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Daily Oat-Based Skin Care Regimen for Atopic Skin: Improvement in IGA Over Time IGA=Investigator’s assessment Fowler JF, et al. J Drugs Dermatol. 2012;11(7):804-807. Dermatologist Assessment: IGA Over Time (Ages 12–60 years)
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Colloidal Oatmeal Regimen for Babies and Children with Atopic Dermatitis Fowler JF, et al. J Drugs Dermatol. 2012;11(7):804-807. N=23 children aged 2 months to 6 years. *P<0.001. †P<0.05
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Dermatologist Assessments: (age 2 months–6 years) P<0.05 vs baseline for all comparisons. VAS=visual analog scale. Lee PW, et al. Poster presented at: 34th Annual Meeting of the Society of Pediatric Dermatology, July 2008. Tolerability and Efficacy of a Colloidal Oatmeal Cream and Cleanser in Infants and Children with mild to moderate Atopic Dermatitis 0 60 50 40 30 20 10 Roughness Week 2 Week 4 Percent Mean Improvement * * Dryness * * * * Itch (VAS)
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Tolerability and Efficacy of a Colloidal Oatmeal Cream and Cleanser in Infants and Children with Atopic Dermatitis Dermatologist Assessments: IGA and EASI Composite Score P<0.05 vs baseline for all comparisons. IGA=Investigator’s Global Assessment; EASI=eczema area severity index. Lee PW, et al. Poster presented at: 34th Annual Meeting of the Society of Pediatric Dermatology, July 2008. 0 60 50 40 30 20 10 Week 4 Percent Mean Improvement Week 2
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Colloidal Oatmeal Cream for Eczema: Study Methods Usual moisturizer stopped Use of basic moisturiser Patient enrolment 1 month washout NOVEMBER 2010 MAY 2011 T0 baseline assessment Colloidal Oatmeal Cream 2 x day Face, body, & eczema areas 1 month Colloidal Oatmeal Cream 2 x day Face, body, & eczema areas Colloidal Oatmeal Cream 2 x day Face, body, & eczema areas 2 months 3 months T4 weeks assessment T8 weeks assessment T12 weeks assessment Patients with a score of 0 at T0 did not enter trial Any patients with a score of 0 did not enter the analysis Colloidal Oatmeal Cream was used as part of the patient’s normal skin regimen; no other product changes were made Data on file. Johnson and Johnson, 2012.
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SCORAD and EASI Severity Scoring of Atopic Dermatitis (SCORAD) Composite index Assesses spread of lesion area, intensity of lesions, and symptoms Calculated score classifies atopic skin as mild, moderate, or severe Eczema Area and Severity Index (EASI) Composite index Assesses percent of body surface area involved and skin pathology Calculated score ranges from 0 to 72 European Task Force on Atopic Dermatitis. Dermatology. 1993;186:23-31. Hanifin JM, et al. Exp Dermatol. 2001;10:11-18.
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All Signs of Mild-to-Moderate Eczema Improved as Skin Hydration Increased *All patients, visual assessment by dermatologist Percentage of patients with improvement in clinical parameters Percent Mean Improvement Data on file. Johnson and Johnson, 2012.
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Colloidal Oatmeal Cream Was Effective in the Younger Age Group* From Week 4 *Children from 6 months to 5 years; visual assessment by dermatologist T4W T8W T12W T4W T8W T12W T4W T8W T12W T4W T8W T12W * ** * * ** ** ** * ** ** Dryness Itching Scaling Redness All parameters improved either significant* or highly significant** * Percent Mean Improvement Data on file. Johnson and Johnson, 2012.
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And in Older Children and Adolescents Subjects from 6–20 years, visual assessment by dermatologist T4W T8W T12W T4W T8W T12W T4W T8W T12W T4W T8W T12W * * * * ** ** * ** ** Dryness Itching Scaling Redness * Percentage improvement compared with baseline visit (6–20 years old) *Significant improvement; **Highly significant improvement Percent Mean Improvement Data on file. Johnson and Johnson, 2012.
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More than 80% of Patients in All Age Groups Saw Improvement in Their Skin Condition Percentage of patients with improvement in skin condition at Week 12 **Assessment by parents for the very young Data on file. Johnson and Johnson, 2012.
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Improvement in SCORAD (Week 12) At Week 12, more than 90% of patients had improvement in SCORAD scores Overall, SCORAD scores improved by a mean of 48.4% In infants and young children (≤5 years of age), the mean improvement in SCORAD scores was 37.1% In children and adolescents (6–20 years of age), the mean improvement in SCORAD scores was 57.7% Data on file. Johnson and Johnson, 2012.
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Colloidal Oatmeal Cream Effect on Corticosteroid use As skin conditions improved with regular use of the colloidal oatmeal cream, subjects reported a decreased need for corticosteroid use. During the washout period, patients averaged 5.5 grams of corticoids After 4 weeks of using colloidal oatmeal cream Measured corticosteroid use declined by 39.4% (9.24 grams/patient)* 63% of patients felt that they used less corticoids/immunomodulators†. *N=19, based on subset of individuals using topical corticosteroids prior to study start. Average use, 2.4 tubes over 12 week study period. †Self assessment questionnaire. Data on file. Johnson and Johnson, 2012.
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Safety Oat Sensitization
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Reports of Oat Sensitization APT=atopy patch testing; OFC=oral food challenge; RMA-repeated and maximized applications; ROAT-repeated open application test; SPT=skin prick test. Boussault P, et al. Allergy. 2007;62(11):1251-1257. Pigatto P, et al. Am J Contact Dermat. 1997;8(4):207-209. Grimalt R, et al. Dermatology. 2007;214(1):61-67. Goujon C, et al. Dermatology. 2009;218(4):327-333.
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Conclusions on Topical Oat Safety While some foods may trigger disease flares in atopics, more so in infants, it is not a common occurrence When foods do cause flares, oats have not been reported as common offenders The majority of studies of topical oat-based products, either in atopics or non atopics, show no propensity toward adverse events While rare cases of clinically important oat allergy may exist, oat-based products are safe and effective in the treatment of the vast majority of individuals
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Summary Colloidal oatmeal is acknowledged by the Food and Drug Administration (FDA) as a safe and effective skin protectant The efficacy of colloidal oatmeal for soothing a range of dermatoses has been established for approximately 50 years Much of the recognized benefit of oats are a result of strong skin protectant benefits and from its phenolic components, especially avenanthramides Oats also contain a mixture of lipids, including phospholipids that are also found in the outer bilayer of the skin Whole oat oil reduces TEWL by as much as 56% The majority of studies of topical oat-based products, either in atopics or nonatopics, show no propensity toward adverse events