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Myastenia gravis PowerPoint Presentation

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Description : a comprehensive body of information on MG with the following headlines : Brief look Classification Signs and symptoms Pathology Diagnosis a) Physical examination b) Blood test c) Electrodiagnostics Management a) Medicine b) Surgery c) Physical activity and Inspiratory muscle therapy

Tags : Myastenia gravis

Published on : May 22, 2021 | Views : 4054 | Downloads : 9

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Slide 1-

In The Name Of GOD Myasthenia Gravis Mana Jameie Shahid Beheshti Unversity Of Medical Sceinces And Health Services
Slide 2-

Outline Brief look Classification Signs and symptoms Pathology Diagnosis a) Physical examination b) Blood test c) Electrodiagnostics Management a) Medicine b) Surgery c) Physical activity and Inspiratory muscle therapy
Slide 3-

Brief Look Autoimmune neuromuscular disease Fluctuating muscle weakness and fatigue Circulating antibodies and acetylcholin receptors Treatment a) Acetylcholinesteras inhibitors b) Immunosuppressants c) Thymectomy incidence
Slide 4-

Classification
Slide 5-

Signs And Symptoms Fatigability Eye and eyelid muscles a) Especially susceptible Facial expression muscles Chewing muscles Talking muscles Swallowing muscles Breathing muscles b) Can also be affected Neck and limbs muscles
Slide 6-

Signs And Symptoms (cont.) The first symptom : a) In most cases: weakness of eye muscle b) In others: difficulty in swallowing and slurred speech Asymmetrical ptosis Diplopia Unstable or waddling gate
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Signs And Symptoms (cont.) Weakness in arms, hands, etc. Change in facial expression Dysphagia Shortness of breath Dysarthria Paralysis of the respiratory muscles in myasthenic crisis
Slide 8-

Pathophysiology Autoimmune channelopathy No relation to cross-reaction Antibodies' acting against nAchR: a) Impairing the ability of acetylcholine to bind to receptors b) Destruction of receptors Complement fixation Elimination of the receptors Antibodies acting against MuSK proteins : Decreasing in patency of the NMJ
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Pathophysiology (cont.) Association with various autoimmune diseases a)Thyroid disease b)Diabetes type 1 c)Rheumatiod arthritis d)Lupus e)Demyelinating CNS diseases
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Diagnosis Physical examination Blood test Electrodiagnostics
Slide 12-

Diagnosis-Physical Examination Looking upward and sideward for 30 seconds: ptosis and diplopia Looking at the feet while lying on the back for 60 seconds Keeping the arms stretched forward for 60 seconds Ten deep knee bends Walking 30 steps on both the toes and the heels Five sit-ups, lying down and sitting up completely
Slide 13-

Diagnosis-Blood Test Identifying certain antibodies: a)Ab against AchR B)Ab against MuSK protein
Slide 14-

Diagnosis-Electrodiagnostics Mal-response of muscles to repeated stimulation Measurement of muscle fatigability
Slide 15-

Management Medication Surgery Physical activation and inspiratory muscle therapy
Slide 16-

Management-Medication Acethylcholinesteras inhibitors Immunosuppressive drugs
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Management-Surgery Thymectomy
Slide 18-

Management-physical activity and Inspiratory muscle therapy Exercise precipitation Diaphragmatic breathing Pursed lip breathing
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