Download Free Medical Metalloid and Metal-Based Drugs PowerPoint Presentation

Metalloid and Metal-Based Drugs PowerPoint Presentation

DOWNLOAD MEDICAL POWERPOINT PRESENTATION

About This Presentation

Description : Check out this medical presentation on Pharmacology, which is titled "Metalloid and Metal-Based Drugs", to know about Metalloid and Metal-Based Drugs.

Tags : Pharmacology, Metalloid, Metal-Based, Drugs

Published on : Jul 20, 2021 | Views : 3012 | Downloads : 2

Shareable Url :

Embed Code :

Comment

Transcript

Slide 1-

Metalloid and Metal-Based Drugs Hiroyuki Kobayashi Zakarian Group Meeting
Slide 2-

Metalloid-based drugs Zakarian Group Meeting
Slide 3-

Definition of metalloids Metalloids are the elements which possess the qualities of metals as well as non metals, hence they are also known as semimetals. Metalloids in the periodic table are placed between the metals and the non metals and are located in a step-like structure. Zakarian Group Meeting
Slide 4-

Metalloids are usually characterized as metallic-looking brittle solids with intermediate to relatively good electrical conductivities, and each has the electronic band structure of a semimetal or semiconductor. Properties of metalloids Zakarian Group Meeting
Slide 5-

Metalloids are usually characterized as metallic-looking brittle solids with intermediate to relatively good electrical conductivities, and each has the electronic band structure of a semimetal or semiconductor. Chemically, they behave as non metals when they react with metals and behave as metals when they react with non metals.They are amphoteric oxides which means they can behave as basic oxides as well as acidic oxides. Properties of metalloids Zakarian Group Meeting
Slide 6-

Metalloids are too brittle to have any structural uses in their pure forms. Typical applications have instead encompassed their presence in, or specific uses as, glasses, fire retardants, alloying components, semiconductors, electronics, and optical storage media. Uses of Metalloids Zakarian Group Meeting
Slide 7-

Metalloids are too brittle to have any structural uses in their pure forms. Typical applications have instead encompassed their presence in, or specific uses as, glasses, fire retardants, alloying components, semiconductors, electronics, and optical storage media. They are also used in many biological processes. B, Si, As and Se are essential trace elements. All metalloid elements have toxic and medicinal properties to greater or lesser degrees. Uses of Metalloids Zakarian Group Meeting
Slide 8-

Application of metalloids in medicinal chemistry Zakarian Group Meeting
Slide 9-

Arsenic compounds resemble in some respects those of phosphorus, which occupies the same group of the periodic table. Arsenic disrupts ATP production through several mechanisms. By competing with phosphate, arsenate uncouples oxidative phosphorylation. The toxicity of arsenic to insects, bacteria and fungi led to its use as a wood preservative or as a feed additive. Arsenic was also used in various agricultural insecticides, termination and poisons. Arsenic (As) Zakarian Group Meeting
Slide 10-

Salvarsan Salvarsan was the first chemotherapeutic compound that was introduced in 1910 as the effective treatment for syphilis. Salvarsan came with considerable risk of side effects, nevertheless demand for this compound remained very strong until 1943 when penicillin became available. Angew. Chem. Int. Ed., 2005, 44, 941
Slide 11-

ppt slide no 11 content not found
Slide 12-

Melarsoprol Melarsoprol is now widely used in the treatment of late-stage human African trypanosomiasis (sleeping sickness). Melarsoprol is extremely toxic to humans, causing life-threatening brain disease in about 5–10 percent of patients. The mechanism of action has never been entirely understood. Sleeping sickness is a parasitic disease caused by Trypanosoma brucei transmitted by the tsetse fly. About 48,000 people died of it in 2008. J. Infect. Dis., 2007, 195, 322 Trypanosoma
Slide 13-

ppt slide no 13 content not found
Slide 14-

Boron atom has a vacant orbital which generates a new stable interaction between a boron atom and a donor molecule through a covalent bond. In biology, borates have low toxicity in mammals (similar to table salt), but are more toxic to arthropods and are used as insecticides. Boric acid has antiseptic, antifungal and antiviral properties and for this reasons is applied as a water clarifier in swimming pool water treatment and eye antiseptics. Boron (B) Zakarian Group Meeting
Slide 15-

ppt slide no 15 content not found
Slide 16-

Bortezomib (VELCADE® ) Bortezomib is the first-in-class proteasome inhibitor for the treatment of multiple myeloma (a plasma cell cancer) approved in the US in 2003. Multiple myeloma was an incurable malignancy that was diagnosed in about 15,000 people in the US each year. Bioorg. Med. Chem. Lett. 1998, 8, 333
Slide 17-

Bortezomib (VELCADE® ) Bortezomib is the first-in-class proteasome inhibitor for the treatment of multiple myeloma (a plasma cell cancer) approved in the US in 2003. Multiple myeloma was an incurable malignancy that was diagnosed in about 15,000 people in the US each year. Bioorg. Med. Chem. Lett. 1998, 8, 333
Slide 18-

BNCT is a combination of treatment with boron and low energy neutrons. Radiotherapy using neutrons can get rid of glioblastoma cells. The boron molecules give off radiation within the brain tumor cells when the external neutron radiation hits them. Boron neutron capture therapy (BNCT) Radiat Res. 2009, 172, 493 1. 10B compound which accumulates in the cancer cell is injected in a patient 2. The neutron beam is irradiated to the lesion 3. The cancer cells are selectively destroyed using a-particles which are generated by the 10B
Slide 19-

Silicon and carbon have similar properties because of their adjacent positions in group 14 of the periodic table. There is no known intrinsic “element-specific” toxicity associated with organosilicon small molecules. Silicones (silicon containing polymers) are used in the applications requiring high biocompatibility such as bandages, breast implants and contact lenses. Silicon (Si) Zakarian Group Meeting
Slide 20-

The medicinal applications of organosilicon molecule are particularly interesting because of differences in the chemical properties of organosilicon molecules compared to carbon-based functional groups. Chemical properties of silicon Zakarian Group Meeting
Slide 21-

The medicinal applications of organosilicon molecule are particularly interesting because of differences in the chemical properties of organosilicon molecules compared to carbon-based functional groups. Chemical properties of silicon Zakarian Group Meeting Chemical properties of organosilicon 1) The larger covalent radius of silicon contributes to about 20% longer bond lengths and different bond angles 2) The increased lipophilicity of organosilicon often enhances cell penetration and alters the potency and selectivity 3) The electropositive nature of silicon contributes to an electron deficient center in a molecule and reversed bond polarization
Slide 22-

Replacement of quaternary C with Si J. Am. Chem. Soc., 2011, 133, 13844 In the influenza A virus M2 proton channel inhibitor, hydrophobicity is known to play a critical role in improving the antiviral potency. The larger size and increased lipophilicity of silicon can provide a better hydrophobic contact between the inhibitor and the channel.
Slide 23-

Trialkylsilyl derivatives of drugs Camptothecin (CPT) is a natural quinoline alkaloid which inhibit DNA topoisomerase I for the treatment of solid tumors. CPT contains an a-hydroxy g-lactone, which reacts with H2O to form inactive ring-opened structure. The trialkylsilyl analogs have been designed to increase the stability of g-lactone. Clin. Cancer. Res., 2005, 11, 3009
Slide 24-

Trialkylsilyl derivatives of drugs Camptothecin (CPT) is a natural quinoline alkaloid which inhibit DNA topoisomerase I for the treatment of solid tumors. CPT contains an a-hydroxy g-lactone, which reacts with H2O to form inactive ring-opened structure. The trialkylsilyl analogs have been designed to increase the stability of g-lactone. Clin. Cancer. Res., 2005, 11, 3009
Slide 25-

ppt slide no 25 content not found
Slide 26-

Silanol as an isostere of alcohol A clinically useful antipsychotic drug, haloperidol is associated with a problematic metabolic pathway. The sila-analogs show a higher potency and selectivity than haloperidol and avoid the formation of a toxic metabolite. Metabolic pathways Chem. Med. Chem., 2008, 3, 152
Slide 27-

Selenium belongs with oxygen and sulfur in the group of 16, so similarities in chemistry are to be expected. The beneficial effects of selenium are strongly dependent on its concentration. Selenium salts are toxic in large amounts, but trace amounts are necessary for cellular function in many organisms, including all animals. Selenium deficiency has been implicated in a number of serious or chronic diseases, such as cancer, diabetes, AIDS and tuberculosis. Selenium (Se) Zakarian Group Meeting
Slide 28-

ppt slide no 28 content not found
Slide 29-

Amselamine Amselamine, which is the seleno analog of amthamine, behave as a histamine H2-agonist with a higher potency than histamine and amthamine. Moreover amselamine exerts hardly any activity for histamine H1 and H3-receptors, which make it selective for the H2-receptor. The selenazole ring of amselamine is somewhat more basic than the thiazole ring of amthamine Bioorg. Med. Chem. Lett. 1994, 4, 1913
Slide 30-

ppt slide no 30 content not found
Slide 31-

Metal-based drugs Zakarian Group Meeting
Slide 32-

Metals are essential for the biological processes of about 30-40% of all known proteins including metalloenzymes which require metal cofactors. Biological metals Zakarian Group Meeting
Slide 33-

Metals are essential for the biological processes of about 30-40% of all known proteins including metalloenzymes which require metal cofactors. The essential metals for humans are Na, K, Ca, Mg, Cu, V, Cr, Mn, Fe, Co, Ni, Zn, Mo and Cd. Low metal ion concentrations may be harmful for the body. Biological metals Zakarian Group Meeting
Slide 34-

Metals are essential for the biological processes of about 30-40% of all known proteins including metalloenzymes which require metal cofactors. The essential metals for humans are Na, K, Ca, Mg, Cu, V, Cr, Mn, Fe, Co, Ni, Zn, Mo and Cd. Low metal ion concentrations may be harmful for the body. Examples of specific types of metal deficiency include: Fe Iron deficiency results in the loss of functional heme proteins, which are responsible for oxygen transport or utilization of oxygen. Zn Zinc deficiency due to diet can result in growth retardation. Cu Copper deficiency in infants results from infants with a poor diet and can cause heart disease. Biological metals Zakarian Group Meeting
Slide 35-

Metals have been used in treatments since ancient times. The Ebers Papyrus from 1500BC is the first written account of the use of metals for treatment and describes the use of Cu to reduce inflammation and the use of Fe to treat anemia. Metal in medical treatment Zakarian Group Meeting
Slide 36-

Metals have been used in treatments since ancient times. The Ebers Papyrus from 1500BC is the first written account of the use of metals for treatment and describes the use of Cu to reduce inflammation and the use of Fe to treat anemia. The application of metals to medicine is a rapidly developing field and novel therapeutic and diagnostic metal complexes are now having an impact on medical practice. Metal in medical treatment Zakarian Group Meeting
Slide 37-

Examples of metal-based drugs Zakarian Group Meeting
Slide 38-

Application of metals in medicinal chemistry Zakarian Group Meeting
Slide 39-

Platinum-based antineoplastic drugs are chemotherapy-agents to treat cancer. They cause crosslinking of DNA as intrastrand crosslinks or DNA protein crosslinks. The resultant crosslinking inhibit DNA repair and/or DNA synthesis in cancer cells. The main dose-limiting side effects of cancer treatment with platinum compounds are nephrotoxicity and peripheral neurotoxicity. Platinum (Pt) Zakarian Group Meeting
Slide 40-

Cisplatin is the first member of a class of platinum-containing anticancer drugs approved by FDA in 1978. It is used to treat various types of cancers, including sarcomas, some carcinomas, lymphomas, and germ cell tumors. Cisplatin Nature 1969, 222, 385
Slide 41-

Cisplatin is the first member of a class of platinum-containing anticancer drug approved by FDA in 1978. It is used to treat various types of cancers, including sarcomas, some carcinomas, lymphomas, and germ cell tumors. Cisplatin Nature 1969, 222, 385
Slide 42-

Cisplatin is the first member of a class of platinum-containing anticancer drug approved by FDA in 1978. It is used to treat various types of cancers, including sarcomas, some carcinomas, lymphomas, and germ cell tumors. Cisplatin Cisplatin metabolites react with N(7) of guanine in DNA and form intrastrand crosslinks, which ultimately triggers apoptosis. Nature 1969, 222, 385
Slide 43-

Carboplatin and Oxaliplatin were subsequently introduced and have since gained popularity in clinical treatment due to its vastly reduced side-effects compared to cisplatin. Carboplatin and Oxaliplatin Dalton Transactions 2010, 39, 8113
Slide 44-

The first reports of gold drugs appeared in 1935, primarily to reduce inflammation and to slow disease progression in patients with rheumatoid arthritis. The mechanism by which these drugs affect arthritis is still unknown. One noticeable side-effect of gold-based therapy is the coloring of the skin in shades of mauve to a purplish dark grey when exposed to sunlight. The application of gold to medicine is called “chrysotherapy”. Gold (Au) Zakarian Group Meeting
Slide 45-

Auranofin is an oral drug approved for treating rheumatoid arthritis in 1985. In 2012, Auranofin was identified as the protozoan agent of human amebiasis. It targets the thioredoxin reductase, preventing the reduction of thioredoxin to reactive oxygen-mediated killing. Auranofin (REDAURA® ) Nature Medicine, 2012, 18, 956 Amebiasis is the fourth leading cause of death due to protozoan infections worldwide, resulting in 70,000 deaths annually. FDA has applied for approval to start clinical trials to treat amebiasis. Amebiasis
Slide 46-

Bismuth is a highly acidic metal ion and may allow it to block Ca2+ channels and to disrupt the cell walls of bacteria. These are also active against the bacterium Helicobacter pylori which is associated with the mucus layer of ulcers and cancers Bismuth drugs are used to treat occasional upset stomach, heartburn, and nausea. It is also used to treat diarrhea. Overexposure to bismuth can result in the formation of a black deposit on the gingiva, known as a bismuth line. Bismuth (Bi) Zakarian Group Meeting
Slide 47-

Bismuth subsalicylate is a drug used to treat temporary discomforts of the stomach and gastrointestinal tract. Commonly known as pink bismuth, it is the active ingredient in popular medications such as Pepto-Bismol. Salicylic acid produces its anti-inflammatory effects via suppressing the activity of cyclooxygenase (COX). BiClO remains in the stomach, and is in intimate contact with the mucus layer, where it stimulates mucus, bicarbonate and prostaglandin secretion. Bismuth subsalicylate Antimicrobial Agents and Chemotherapy 1989, 33, 2075
Slide 48-

In China, mercury use was thought to prolong life, heal fractures, and maintain generally good health, although it is now known that exposure to mercury leads to serious adverse health effects. Today, the use of mercury in medicine has greatly declined in all respects, especially in developed countries. Mercury compounds are found in some over-the-counter drugs, including topical antiseptics, stimulant laxatives, diaper-rash ointment, eye drops, and nasal sprays. Mercury (Hg) Zakarian Group Meeting
Slide 49-

ppt slide no 49 content not found
Slide 50-

As ruthenium is in the same group as iron, ruthenium complexes are able to take advantage of the body’s ability to efficiently transport and uptake of iron. In recent years, ruthenium-based molecules have emerged as promising antitumor and antimetastatic agents. Ruthenium compounds are usually less toxic and no cross resistant than platinum counterparts, therefore better tolerated in vivo. In animal models, ruthenium compounds are effective in the treatment of cancer types which cannot be treated by platinum compounds, most probably due to a different mode of action. Ruthenium (Ru) Zakarian Group Meeting
Slide 51-

NAMI-A and KP1019 are two potential ruthenium drugs in phase II clinical trials. Despite their structural and chemical similarities, these two ruthenium complexes show distinct antitumor behaviors. NAMI-A and KP1019 NAMI-A induces cell arrest in the premitotic G (2)-M phase, strongly inhibits metastasis without effects on the primary tumor. KP1019 induces apoptosis in colorectal tumor in which cisplatin is inactive, via intrinsic mitochondria apoptosis pathway. Cancer Chemother Pharmacol 2010, 66, 1
Slide 52-

Staurosporine is known as a nonspecific protein kinase inhibitor. By replacing the globular carbohydrate unit of staurosporine with Ru fragment, a series of selective inhibitors of GSK3 were discovered. Ru as Protein kinase inhibitors J. Am. Chem. Soc., 2004, 126, 13594
Slide 53-

ppt slide no 53 content not found
Slide 54-

Metalloid and metal based drugs are used as chemotherapeutic agents to combat Infectious diseases caused by pathogenic parasites, cancers, inflammation, mental disorders, infection etc. It is clear that metalloid and metal based compounds offer new properties that cannot be found amongst purely organic agents. The therapeutic application of metalloids and metals is still an unexplored area of research and continued work in this area is warranted. Summary Zakarian Group Meeting
Slide 55-

Presentation Name | CONFIDENTIAL Zakarian Group Meeting