Download Free Medical Malignant Bone Tumors PowerPoint Presentation

Malignant Bone Tumors PowerPoint Presentation

DOWNLOAD MEDICAL POWERPOINT PRESENTATION

About This Presentation

Description : Check out this medical presentation on Bone Cancer (Sarcoma of Bone), which is titled "Malignant Bone Tumors", to know about the malignant and benign tumors of bone.

Tags : Bone Cancer, Sarcoma of Bone, Malignant Bone Tumors, benign tumors, Osteosarcoma, Osteogenic sarcoma, Chondrosarcoma, Ewing’s sarcoma, Multiple myeloma

Published on : May 10, 2021 | Views : 4908 | Downloads : 44

Shareable Url :

Embed Code :

Comment

Transcript

Slide 1-

Malignant Bone tumors
Slide 2-

Malignant vs. Benign Tumors “Rapid growth, warmth, tenderness, and ill defined edges are suggestive of malignancy.”
Slide 3-

Classification of malignant tumors of bone: Osteosarcoma (Osteogenic sarcoma) Chondrosarcoma Ewing’s sarcoma Multiple myeloma
Slide 4-

Osteosarcoma (Osteogenic sarcoma) It is a malignant mesenchymal tumor in which cancellous cell produce bone matrix. Most common primary malignant tumor of bone Occurs in all age group but has bimodal age distribution 75% occur in person younger than 20 years of age Second peak occur in elderly who have predisposing condition – Paget disease, bone infarct, prior irradiation Males> females
Slide 5-

Usually arise from metaphysis of long bones of extremities, and almost 50% occur about the knee. Beyond the age of 25 years incidence in flat bones and long bones is almost equal.
Slide 6-

Pathogenesis Approx. 70% have acquired genetic abnormalities such as ploidy changes and chromosomal aberrations, none of which is specific for this tumor. Mutation of RB gene (cell cycle regulator) and p53 gene (gene whose product regulate DNA repair and cellular metabolism) frequently associated with osteosarcoma. Germline mutation in RB gene roughly 1000-fold increase the risk of osteosarcoma Patient with Li-Fraumeni syndrome (germline p53 mutation) greatly elevate the incidence of osteosarcoma.
Slide 7-

Several subtypes of osteosarcoma are grouped according to – Site of origin (intramedullary, intracortical or surface) Degree of differentiation Primary (underlying bone is unremarkable)or secondary to preexisting disorders. Histological features (osteoblastic, chondroblastic, fibroblastic, telangiectatic, small cell and giant cell). The most common subtype arises in metaphysis of long bones and is primary, solitary, intramedullary and poorly differentiated. Grossly, Osteosarcoma are big bulky tumors that are gritty, grey-white, and often certain areas of hemorrhage and cystic degeneration.
Slide 8-

Osteosarcoma
Slide 9-

Osteosarcoma
Slide 10-

Clinical features Localized pain and swelling Fast growing tumor Progressive weakness and weight loss Skin over the tumor is shiny and stretched with prominent veins Warm, tender and ill defined margins. Pulsatile tumor Movement of adjacent joint restricted due to mechanical obstruction and effusion. Regional lymph node enlarged only in 25-30% cases. If distal neurovascular deficit present strongly suggest malignancy. Lung metastasis occur in 10-12 months if left untreated.
Slide 11-

Classic X-ray findings: Codman's triangle (periosteal elevation) Sunburst pattern/Sunrays appearance Bone destruction Ill-defined margins
Slide 12-

Codman’s triangle Sunrays appearance Osteosarcoma
Slide 13-

Codman's triangle Osteosarcoma
Slide 14-

Osteosarcoma
Slide 15-

Secondary osteosarcoma: Occurs in old people Associated with Paget’s disease or chronic osteomyelitis Highly aggressive
Slide 16-

Differential diagnosis Among primary and secondary bone tumors Sub acute and chronic osteomyelitis
Slide 17-

Treatment Classical M.C.D WLE M.C.D 70% 5 yrs survival rate M – Methotrexate C – Cyclophosphamide D - Doxorubicin T10 protocol High dose MTX WLE Biopsy > 95% necrosis < 95% necrosis chemosensitive chemoresistant M.C.D Multiple drugs (except MCD & etoposide)
Slide 18-

Surgery Disarticulation Amputation Resection with reconstruction/endoprosthesis Limb salvage surgery Resection of metastatic lesion (lobectomy in lung)
Slide 19-

Limb salvage surgery Principle is to eradicate the bone tumor, retain integrity of skeletal system and preserve the limb with useful function. After resection, skeletal reconstruction done by bone grafting(auto or allograft) or by endoprosthesis (modular or custom made). Prosthetic reconstruction is more effective As compared to the radical amputation and external prosthetic fitting or limb sparing surgery with bone grafting this treatment is more effective in early mobilization.
Slide 20-

ppt slide no 20 content not found
Slide 21-

ppt slide no 21 content not found
Slide 22-

Chondrosarcoma Definition: Malignant tumor of chondroblasts cells Second most common malignant matrix producing tumor Etiology: The tumor may arise de novo (primary) or secondary to preexisting enchondroma, exostosis (osteochondromas) or Paget’s disease Primary chodrosarcoma is very uncommon, arises centrally in the bone and found in children
Slide 23-

Chondrosarcoma sub classified according to – Site – Central (intramedullary) Peripheral (juxtacortical and surface) Histologically - Conventional (hyaline/myxoid) Clear cell Dedifferentiated Mesenchymal Conventional central tumors constitute about 90% of chondrosarcoma
Slide 24-

Occur more commonly after 40 years of age Clear cell and especially mesenchymal variant occur in younger patients in their 20s. Male > female It is most common in the femur, humerus, ribs and on the surface of the pelvis Patients with Ollier's disease (multiple enchondromatosis) or Maffucci's syndrome (multiple enchondromas and hemangiomas) are at much higher risk of chondrosarcoma than the normal population.
Slide 25-

Clinical features Presentation of chondrosarcoma depends on the grade of the tumor. A high-grade, fast growing tumor can present with excruciating pain. A low grade, more indolent tumor is more likely to present as an older patient complaining of hip pain and swelling. Pelvic tumors present with urinary frequency or obstruction or may masquerade as "groin muscle pulls".
Slide 26-

Investigations X – ray – Chondrosarcoma is a fusiform, lucent defect with scalloping of the inner cortex and periosteal reaction. Extension into the soft tissue may be present as well as punctate or stippled calcification of the cartilage matrix.
Slide 27-

Chondrosarcoma
Slide 28-

C.T. scan – Helpful in defining the integrity of the cortex and distribution of calcification. MRI – Surgical planning as it demonstrates the intraosseus and soft tissue involvement of the tumor. MRI is also helpful in evaluating possible malignant degeneration of osteochondromas by allowing accurate measurements of the cartilage cap
Slide 29-

Biopsy - Incisional biopsy done Gross examination – Chondrosarcoma is a grayish-white, lobulated mass. It may have focal calcification, mucoid degeneration, or necrosis
Slide 30-

Chondrosarcoma
Slide 31-

Treatment Treatment of chondrosarcoma is wide surgical excision. There is a very limited role for chemotherapy or radiation. Low grade tm. – Limb salvage surgery(WLE) High grade tm. - Amputation
Slide 32-

Ewing’s sarcoma Malignant neoplasm of undifferentiated cells arising within the bone marrow cavity Ewing's sarcoma is a highly malignant tumor that is a type of peripheral primitive neuroectodermal tumor Found in the lower extremity more than the upper extremity, but any long tubular bone may be affected. Most common sites are the diaphysis and metaphysis of the femur followed by the tibia and humerus. Most common in the first and second decade Ratio of male to female is 3:2.
Slide 33-

Clinical features Presented with pain, swelling and tenderness Erythema and warmth of the local area are sometimes seen Osteomyelitis is often the initial diagnosis based on intermittent fevers, leukocytosis, anemia and an increased ESR. Contain glycogen granule so can cause hyperglycemia
Slide 34-

Investigation X-ray: Concentric, onion-skin layering of new periosteal bone This appearance is caused by and splitting and thickening of the cortex by tumor cells. The lesion is usually lytic and central. CT is helpful in defining bone destruction. MRI is essential to elucidate the soft tissue involvement
Slide 35-

Onion peel appearance
Slide 36-

Differential Diagnosis Infection Neuroblastoma metastasis Lymphoma Leukemia
Slide 37-

Open biopsy for bone lesions Grossly, the tumor is gray to white in color and poorly demarcated. The consistency is soft and gray and sometimes semi-liquid especially after breaking through the cortex. Areas of hemorrhage and necrosis are common. Ewing sarcoma
Slide 38-

Treatment Chemotherapy – A – Actinomycin D B – Bleomycin C – Cylophosphamide D – Doxirubicin Surgery followed by adjuvant chemotherapy. Radiotherapy
Slide 39-

Poor Prognostic Factor High grade tumour Age > 12 yrs Male H/O fever and increase TLC Proximal lesion Larger lesion Metastasis Chemoresistant
Slide 40-

MULTIPLE MYELOMA/ PLASMACYTOMA Multiple myeloma is a malignant tumor of plasma cells that causes widespread osteolytic bone damage. Multiple myeloma is the most common primary tumor of bone. Found in the spine, skull, ribs, sternum and pelvis but may affect any bone with hematopoietic red marrow. There are chromosomal abnormalities that are associated with MM, such as 14q32 and deletion of chromosome 13, and these findings are more likely to be found in cases with poor outcome. Other diseases, such as solitary plasmacytoma and monoclonal gammopathy are associate with MM.
Slide 41-

Average age of the patients at diagnosis is 65 years. Men are slightly more likely to get multiple myeloma than women.
Slide 42-

Causes Multiple myeloma may occur spontaneously On exposure to ionizing radiation and the pesticide dioxin Infection with some viruses (HIV and human herpes 8) has also been associated with multiple myeloma. No known risk factors are inherited.
Slide 43-

SYMPTOMS Usually bone pain is main complain. Other symptoms include: Fatigue Feeling ill Fever Night sweats Weight loss is not common in the early stages. Patients are pale with diffuse bone tenderness, especially around the sternum (breastbone) and pelvis (hips).
Slide 44-

Spine is the most common location for a pathological fracture. It can also happen in the ribs and pelvis. Compression of the spinal cord in 10%-15%This causes pain in the back and legs and numbness and weakness in the legs. Patients who have high levels of calcium in the blood may experience nausea, fatigue, confusion, constipation, and frequent urination. Patients with anemia may experience fatigue, weakness, and shortness of breath with exercise. In advanced cases, patients typically have recurrent infections and can have kidney failure.
Slide 45-

Investigations Blood and urine tests – Monoclonal immunoglobulin (Ig G)is found on serum electrophoresis and on urinalysis. Immunoglobulin (Ig) is the protein that is produced by the tumor cells. Light chain subunits of immunoglobulin are called Bence Jones proteins and are present in urine. Bone marrow aspiration and/or biopsy – A procedure that involves taking a small amount of bone marrow fluid (aspiration) and/or solid bone marrow tissue (called a core biopsy), usually from the hip bones, to be examined for the number, size, and maturity of blood cells and/or abnormal cells.
Slide 46-

DIAGNOSIS X-ray - a diagnostic test Punched out lesion in skull When only one lesion is found it is called a plasmacytoma Magnetic resonance imaging (MRI) - a diagnostic procedure.
Slide 47-

Differential Diagnosis Ewing sarcoma Lymphoma Leukemia Acute infection
Slide 48-

CHEMOTHERAPY The standard treatment medications are melphalan and prednisone. The median survival rate is three years with this treatment alone. For patients in whom this therapy is ineffective, alternatives include: VBMCP (vincristine, carmustine, melphalan, cyclophosphamide and prednisone) VAD (vincristine, adriamycin and dexamethasone)
Slide 49-

A recent advancement in the treatment of multiple myeloma has increased, response rates and survival. This treatment consists of high-dose chemotherapy, followed by autologous stem cell transplantation. With this treatment, patients have a 20 percent chance of living longer than 10 years. This stem cell transplantation involves: Harvesting a patient's own blood cells Conditioning them with very high doses of melphalan Re-infusing the blood cells back into the patient
Slide 50-

RADIATION THERAPY Radiation therapy is reserved for decreasing the size of symptomatic bone lesions.
Slide 51-

SUPPORTIVE CARE Supportive care is critical. Supportive care includes managing the bone disease, anemia, infections, kidney failure, and pain associated with multiple myeloma. Bisphosphonates (medication) can prevent destructive bone lesions and spine fractures. Erythropoetin or occasional blood transfusions can manage anemia. Antibody infusions and vaccinations can help patients with recurrent infections. Corticosteroids and hydration can be used to treat high blood calcium concentrations (from bone loss) and dehydration. Narcotics can decrease the pain associated with bone lesions. Operative intervention may be required to stabilize and control the pain associated with bone fractures.
Slide 52-

SURGICAL TREATMENT Surgery will not cure multiple myeloma. Surgery is used to treat fractures and impending fractures in the spine, pelvis, hip, and shoulder. The goal of these surgeries is to decrease pain and maintain function. Internal fixation augmented with cement is frequently recommended, as are joint replacements and vertebroplasties (for spine fractures). Operative intervention does not alter the survival rate, but it does increase the quality of life.
Slide 53-

Bone Metastasis It is catastrophic complication for most patient of cancer. Usually occur in elderly age group Clinical features – Pain Metastatic destruction of bone reduces load bearing capacity. Usually manifests as complication like pathological fracture, paraplegia (medullary compression), pressure symptoms.
Slide 54-

M/C cause – Lung Carcinoma Male – Prostate Carcinoma Female – Breast Carcinoma M/C Area – D-L Spine In prostate carcinoma – Pelvis > Lumber spine > Dorsal spine
Slide 55-

M/C lesion – Lytic lesion Purely osteoblastic sec. – Prostate - Carcinoid Metastasis do not cross elbow and knee
Slide 56-

Bone tm. Which have bony metastasis – Osteosarcoma Neuroblastoma Ewing sarcoma
Slide 57-

THANK YOU