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Description : IP in Life Sciences – Digital Health Solution.

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Presentation at 9th Berlin Conference on IP in Life Sciences – Digital Health Solution 12th February 2016 What’s the market pull for E-Health?
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What’s the market pull for E-Health.pptx 2 There is clearly a market pull towards digitalization, across industry and in healthcare 73.2 73.2 233.3 +21% 2020 233.3 135.9 135.9 …and creates strong pull in healthcare Source: Roland Berger team analysis Digitalization is disrupting traditional industries… 2014 2017 Digital health market [bn USD]
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What’s the market pull for E-Health.pptx 3 DIGITAL TRANSFORMATION A TECHNOLOGICAL REVOLUTION Across industries, a technological and a sociological revolution are under way A SOCIOLOGICAL REVOLUTION Source: Roland Berger Trend overview TECHNOLOGY ADVANCES The world is connected via the internet Powerful computing & communication devices are increasingly mobile DATA VOLUME INCREASES More and more digital data is generated The belief in mutual enrichment by exchange fuels data sharing CONSUMER/PATIENT BEHAVIOR CHANGES Consumers/patients have increasing access to transparent information The 'informed patient' is transforming to the 'participating patient' START-UP ACTIVITIES INCREASE VCs believe in business models that are designed for this new environment BIG DATA CHANGES TRADITIONAL BUSINESS Existing businesses must identify the value of data for their industry if they want to be sustainable in the future
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What’s the market pull for E-Health.pptx 4 The major challenge in modern medicine is the interpretation of enormous amounts of data within human biological networks Source: Hood and Flores; Naylor and Chen; Roland Berger Holistic approach to studying complex biological systems Systems medicine evolved from systems biology Systems biology is the study of systems of biological components, which may be molecules, cells, organisms or entire species Systems biology is pioneering actionable understandings of disease and wellness as a continuum of network states unique in time and space to each individual human being Systems medicine aims at better understanding processes within the human body at molecular level and its interactions The major challenge for systems medicine is to find the significant signals within this enormous amount of individual data and enhance the signal- to-noise ratio Complexity and variability of humans Systems medicine Organs Populations … Molecules Genes 50 organs 100 trillion cells 35,000 orfs 6 bn nucleotides 20,000 proteins Cells Microbiome Cytome Metabolome Proteome Transciptome Epigenome Genome Multi-Omics Organisms
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What’s the market pull for E-Health.pptx 5 In our view, winning Digital Health offerings must fulfill a clear set of principles to make it attractive Source: Roland Berger Team Principles of winning Digital Health offerings e-Health Offering Follow customer journeys – target specific interactions in the healthcare system Connect all stakeholders across the healthcare system Overcome disconnect between healthcare provider and patient Use smart solutions, offer tangible value added: time, money, quality, outcomes Get the initial patient connection right - ubiquitous digital channels: Social media, website, apps as touch points (mobile network of connectivity) Take advantage of comprehensive user data Ensure accessibility and security Gather meaningful insights Use Big Data to become predictive, not reactive Use multiple interfaces to suit the patients‘ lifestyle Link with technology standards and build closed loop system Value-added Data Platform/ connectivity Device Give precise measurements Considers patient convenience with e.g. wearable sensors Add new technology dimension to core product Enhance value proposition beyond the molecule Reflect regulatory & care environment Understand and accept local pain points – adjust technology and value added Pharmaceutical Intelligence Sensor Regional Interaction
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What’s the market pull for E-Health.pptx 6 Market pull is mainly driven by new entrants, consumers, insurances, government and industry – players move to the right Market pull of selected healthcare players – European perspective Pushing Reluctant Neutral Attitude towards e-Health Healthcare Industry Public sector Payer organizations Care provider New entrants Development of new business models and Pharmacy Reluctant since fear of e-prescriptions investment needed Some see opportunity to drive compliance/ adherence Medtech Some segments shape digitalization Pharma Opportunities across the value chain Different priorities Government Embraces opportunities to increase transparency and efficiency Statutory insurances Strong interest in transparent information and improved patient care at lower cost Private insurances Positive but cautious Limited market power Office based physicians Doubts concerning patient/ doctor relation data security/ protection medical independence more than others partnerships Patients/ Consumers Hybrids with increasing digital habits Information needs Private Providers Promising potential to improve patient pathways and efficiencies Public Providers Reluctant concerning investment needs Source: Roland Berger Analysis
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What’s the market pull for E-Health.pptx 7 > KOLs > Patients > Biotech > Clinical centers Diagnostics > Physicians > Hospitals > Payers groups > Patient KOLs Consumers > Suppliers > Technical service providers > Consumer > Payers > Patient > Hospitals Pharmacies Industrial healthcare players identifying opportunities across the value chain Industry 4.0 Digital health Multichannel management Smart data Pharma Company Digital tool Target groups Manufacturing / Supply chain Medical / Marketing R&D Sales Industrial value chain Smart data Industry 4.0 Digital health Multichannel management Source: Roland Berger
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What’s the market pull for E-Health.pptx 8 Roche decided to exploit the market potential stemming from digitalization mainly in the R&D area Source: Roland Berger, Roche press releases R&D R&D approach Focus of the R&D collaboration will be on developing genomic profile tests for cancer immunotherapies and for continuous blood-based monitoring Roche will be able to utilize FMI’s proprietary molecular information platform to standardize clinical trial testing Roche aims for comparability of clinical trial results for R&D purposes to improve decision making and support optimization of patient care as oncology management becomes more complex Digitalization will further link R&D with real life treatment data Roche's strategic transaction regarding Foundation Medicine In 2015, Roche acquired a majority stake in Foundation Medicine, a new player in the field of molecular information in oncology FMI supports physicians by providing comprehensive molecular information to characterize a tumor that is being matched with approved targeted therapy options and novel treatments under development Collaboration leverages both companies’ strengths to advance the progress of personalized treatments for patients with cancer The partnership includes both a broad R&D collaboration with the potential for more than USD 150 million funding by Roche to accelerate FMI’s new product development as well as commercial collaboration agreements aimed at expanding the global sales efforts for FMI’s current and future products
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What’s the market pull for E-Health.pptx 9 New technologies have the potential to disrupt the Medtech and Pharma manufacturing world Selected Industry 4.0 technologies and use cases Virtual Manufacturing Additive Manufacturing Predictive maintenance Cyber physical systems > 3D CT data and the NX- CAD/CAM software from Siemens PLM enable simulation and design of customized and patient- specific artificial joints with still a high degree of process chain automation > In March of 2015, 3D Bioprinting Solutions became the first group to successfully bioprint and transplant a thyroid gland for a mouse > ThyssenKrupp uses Microsoft predictive analytics software for its elevator maintenance support Elevators are connected to a cloud and transfer data from sensors to the system for predictive and even preemptive maintenance > On the assembly line at the Bosch Rexroth plant Homburg / Saar, an RFID chip on the work piece steers its own production steps through nine intelligent work stations Displays show the employees the appropriate work instructions Mfg. / Supply chain Source: Roland Berger analysis
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What’s the market pull for E-Health.pptx 10 Digital offerings are manifold and will change the way how people are treated tremendously – Pharma’s offerings will be impacted Apple Health > Currently focuses on collection of health and fitness information from third- party apps Glucose monitor in development using non- invasive sensors Takes advantage of pedometer, blood pressure, hydration and heart rate screening Bayer BETACONNECT™ > Prescribes injection reminders, injection depth and speed based on patient preferences Stores and shares injection information (date, speed, volume) and symptoms and syncs live with smartphone app Shares the data with healthcare providers via an online dashboard FDA approval in 09/2015 23 and me > FDA and CE approval DNA analyzer that enables users to learn about and explore their DNA Extrapolates ancestry reports and raw data from its database Future use for health-related genetic information anticipated Proteus digital > Available in the USA Marketed as an intelligent medicine platform integrating patients, patients’ relatives and treating doctors Includes wearable and ingestible sensors Developed in cooperation with Novartis and Otsuka Pharmaceuticals FDA application for first drug/device combination (ABILIFY) ongoing Source: Roland Berger Medical / Marketing
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What’s the market pull for E-Health.pptx 11 Sales Digitalization within healthcare sector gives birth to new business models enabling self-monitoring, higher efficiency & convenience Major Digital Health trends Quantified health Tele-health Medication online Source: e.ventures; Roland Berger "Extending the point of care" "Pharmacy reinvented" Telemedicine services connecting patients directly with doctors via video allow for higher convenience at lower costs Monitoring of at-risk patients simplified especially in the field of chronic diseases Simplified process of getting prescriptions or receiving medication through faster submission technologies e.ventures "Wearables becoming says: smarter" Tracking of physical activity and other health indicators due to rise of wearable technologies and sensors Features of new devices going beyond fit- ness and are more sophisticated than ever Record memories on the go Activity & diet tracking Fitness & sports activity tracking Online connection to your doctor Tele-health platform connecting doctors & patients Online pharmacy
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What’s the market pull for E-Health.pptx 12 Which new business models emerge from the associated digital transformation? Where is the potential of the new paradigm in modern medicine and how can digital transformation help unlock this potential? What are the drivers and hurdles for digital transformation of Pharma and Healthcare and how does it change the paradigm in modern medicine? How can the opportunities arising from digital transformation in pharma and healthcare be addressed? So for moving forward – what are the guiding questions to be answered?
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What’s the market pull for E-Health.pptx 13 Strategic cooperation to face new business reality Pharma Medtech IT Consumer industries Telecommunications Strategic collaboration will become more important than ever for established players to succeed in the new business environment Conclusion Implement out-of-the-box innovation into a highly regulated environment Combine development cycles and know-how from IT and medicine Open up for partnerships Achieve quick wins to keep going Exemplary partnerships and initiatives of established Pharma players with other industries Google and Sanofi collaborate in Diabetes Care Roche acquires Big Data platform Bina Technologies for next generation sequencing Source: Roland Berger Challenges
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What’s the market pull for E-Health.pptx 14 On our first "Digital Health Day" on February 25th at spielfeld we are connecting industry leaders with promising start-ups "Digital Hub" in Berlin Digital Health Day Source: Roland Berger Strong network of digital- /tech-partners and start- ups 1,000m2 multi-functional space Broad portfolio of services from inspiration formats to prototyping and change projects Several top-companies working on digital projects, curated by RB Digital Academy Big/Smart Data Lab Senior executives will meet innovative start-ups to discuss disruptive and successful business models Clients will have the opportunity to develop own ideas through an idea generation workshop, and to develop and implement concepts in follow-on projects Selected participants:
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