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Introduction to Pathology PowerPoint Presentation

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Description : Check out this medical presentation on Pathology, which is titled "Introduction to Pathology", to know about Pathology as a "Study and diagnosis of disease”.

Tags : Pathology, Introduction, Study, diagnosis, disease

Published on : Aug 06, 2021 | Views : 3919 | Downloads : 0

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Slide 1-

Introduction to Pathology OPTOM FASLU MUHAMMED
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Pathology –” Study and diagnosis of disease” 4 components of pathology Cause /etiology Mechanism of develop- Pathogenesis Structural alteration of the cell- Morphologic changes Consequences of these changes – Clinical Manifestations
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一、 History of Pathology Autopsy → Organ pathology (1761) Cellular pathology (1854) Ultrastructural pathology with the application of EM (20 century 60s) Immunopathology, Molecular pathology, Genetic pathology, Quantitative pathology
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2. Classification: (1) Human pathology (2) Experimental pathology 3. Position: It’s a bridging discipline involving both basic science and clinical practice Autopsy Biopsy Cytology
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4. Text of Pathology: General pathology: concerned with the basic reaction of cells and tissues to abnormal stimuli that underlie all diseases. Systemic pathology : dedcribe the specific responses of specialized organs and tissues to defined stimuli.
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三、 Techniques of Pathology Human pathology Autopsy Biopsy: surgical or diagnostic pathology Cytology: smear, fine needle aspiration Experimental pathology Animal experiment: animal model Tissue and cell culture
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四、 Observation and New Technique of Morphology （一） Gross appearance: size, shape weight color consistency surface edge, section
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（二） Histologic and cytologic observation: most common and basic formalin fixed → HE (hematoxylin and eosin) stained Hemangioma of ventrical wall
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（三） Histochemistry and cytochemistry PAS→BM
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（四） Immunohistochemistry Ag-Ab specific reaction Applications Location analysis cytokeratin→cell membrane Clinical diagnosis and distinguishing diagnosis of tumor histogenesis
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Leiomyosarcoma Actin (+)
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（五） Ultrastructural obTsEeMrv(atrtainosnmitting electron microscope) Filtering membrane
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SEM (scanning electron microscope) Podocyte
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（六） Flow cytometry (FCM) One kind of cells→quantitative DNA ploidy analysis Protein nucleus acid→quantitative analysis Selection of collection of cells
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（七） Image analysis (IA) Nuclei: diameter; circumference; area; volume; morphology （八） Laser scanning confocal microscope (LSCM) a living cell→observation in situ or development or quantitative
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（九） Molecular biology technique Polymerase chain reaction (PCR) DNA sequencing Biochip technique Gene chip (DNA chip) Protein chip (protein microarray) Tissue chip (tissue microarray)
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Polymerase chain reaction (PCR)