Download Free Medical IMAGING IN MEDIAL TEMPORAL EPILEPSY PowerPoint Presentation

IMAGING IN MEDIAL TEMPORAL EPILEPSY PowerPoint Presentation

DOWNLOAD MEDICAL POWERPOINT PRESENTATION

About This Presentation

Description : Check out this medical presentation on Radiology and Imaging, which is titled "IMAGING IN MEDIAL TEMPORAL EPILEPSY", to know about imaging in MTE.

Tags : Radiology, Imaging, MEDIAL TEMPORAL EPILEPSY, MTE

Published on : Jul 28, 2021 | Views : 2394 | Downloads : 3

Shareable Url :

Embed Code :

Comment

Transcript

Slide 1-

IMAGING IN MEDIAL TEMPORAL EPILEPSY DR.SARATH MENON.R,MD(Med.),DNB(Med.),MNAMS DM RESIDENT DEPT.OF NEUROSCIENCES AIMS,KOCHI
Slide 2-

WHY WE NEED TO KNOW IMAGING IN MTE? In medically refractory epilepsies A Dedicated MRI protocol helps us to detect an epileptogenic lesion in 80% cases. Resection of the lesion can lead to seizure freedom in many such cases.
Slide 3-

ppt slide no 3 content not found
Slide 4-

ppt slide no 4 content not found
Slide 5-

RADIOLOGICAL ANATOMY OF MEDIAL TEMPORAL LOBE STRUCTURES Medial temporal lobe structures – amygdala hippocampus Surrounding hippocampal region ( perirhinal, parahippocampal and entorhi nal)
Slide 6-

HIPPOCAMPUS Club-shaped structure divided into three parts: head, body, and tail. In coronal plane form an S-shaped configuration. Consists of two interlocking C-shaped structures: cornu ammonis and the dentate gyrus. the Gray matter of the hippocampus is an extension of the subiculum of the parahippocampal gyrus.
Slide 7-

ppt slide no 7 content not found
Slide 8-

ppt slide no 8 content not found
Slide 9-

ppt slide no 9 content not found
Slide 10-

ppt slide no 10 content not found
Slide 11-

ppt slide no 11 content not found
Slide 12-

Note head digitations, subiculum, subsectors of Ammon’s horn, dentate gyrus, alveus, fimbria, stratum radiatum and collateral white matter
Slide 13-

On MRI, the hippocampal head is seen in the same coronal plane as the interpeduncular cistern Coronal T2 at the level of the interpeduncular cistern showing the amygdala (large square), uncal fissure (large dot), hippocampal head (small dot)
Slide 14-

The body of the hippocampus is seen at the level of the midbrain (Fig. 7). It is ovoid in shape and is the most uniform portion. It lies inferior to the choroidal fissure and is separated from the parahippocampal gyrus by the hippocampal fissure. Coronal T2 WI at the level of the midbrain, demonstrating the ovoid hippocampal body (small sqaure) under the choroidal fissure (circle).
Slide 15-

The tail of the hippocampus is located at or behind the midbrain where it is seen adjacent to the crura of the fornices Coronal T2 WI just posterior to the midbrain illustrating the fornix (line) and hippocampal tail (square).
Slide 16-

DEFINITION OF MTS Mesial temporal sclerosis -coined by Falconer & colleagues – by neuronal loss and gliosis involving principally the hippocampus and amygdala, or both, but occasionally extending to other mesial temporal structures or even throughout the temporal lobe, and leading to generalized atrophy and gliosis.
Slide 17-

Hippocampal sclerosis : Gliosis and neuronal loss that particularly affects the CA1, and CA4 or Sommer’s sectors, the dentate gyrus, and the subiculum. Ammon’s horn sclerosis abnormalities restricted to the areas CA1 and CA4. Amygdalar sclerosis
Slide 18-

HS is unilateral in about 80% of cases Most frequent lesional pattern : Ammon’s horn sclerosis in the CA1 and CA4 sections Less frequent patterns include widespread cell loss in the hippocampus Severity of cell loss may vary but it is usually >50% in association with gliosis
Slide 19-

IMAGING IN MTE MRI is far superior to CT Use cuts oriented in two orthogonal planes along the long axi of the body of the hippocampus and at a right angle to this s Prevents from obtaining oblique images of the hippocampus, which can be difficult to interpret due to partial volume effects. High resolution MRI (slice thickness 1.5 mm) is the method of choice
Slide 20-

MRI EPILEPSY PROTOCOL T1WI Superior for cortical thickness and the interface between grey and white matter. FLAIR Look very carefully for cortical and subcortical hyperintensities on the FLAIR, which can be very subtle. T2* or SWI Helpful when searching for haemoglobin breakdown products as in posttraumatic changes and cavernomas, or to look for calcifications in tuberous sclerosis, Sturge-Weber, cavernomas and gangliogliomas.
Slide 21-

ppt slide no 21 content not found
Slide 22-

Volumetric pulse sequences with reformatting of thin sections Parallel and perpendicular to the long axis of the hippocampi represent a valid tool. FIRMS:fast inversion recovery pulse sequence with white matter signal suppression Since CSF artifacts are incompletely suppressed on FLAIR
Slide 23-

OTHER MODALITIES MR Hippocampal Volumetry MR Hippocampal T2 Relaxometry MRS SPECT PET
Slide 24-

MRI IN MTE MRI has the ability to detect subtle alterations in cortical architecture & changes in signal intensity most sensitive and specific imaging technique for non-invasive identification of these epileptogenic foci
Slide 25-

ppt slide no 25 content not found
Slide 26-

ATROPHY AND HIGH SIGNAL IN MTE The coronal T2WI and FLAIR images show right-sided mesial temporal sclerosis. Notice the volume loss, which indicates atrophy and causes secondary enlargement of the temporal horn of the lateral ventricle. The high signal in the hippocamous reflects gliosis.
Slide 27-

35-year-old patient with refractory temporal lobe epilepsy. MR shows subtle hyperintensity of the left hippocampus on the axial FLAIR (blue arrow) and atrophy of the left hippocampus on coronal images (yellow arrow).
Slide 28-

Right sided hippocampus showing- Smaller in size Loss of internal structure Bright on T2
Slide 29-

a Rotated coronal FSE T2-weighted image at hippocampal body. b Reformatted coronal image after corrections of head rotation better shows left hippocampal atrophy (arrow)
Slide 30-

Left amygdalo-hippocampal sclerosis. Coronal FLAIR (a) and axial FSE T2-weighted (b) images show hyperintense lesion involving the amygdala and head of hippocampus on the left.
Slide 31-

Bilateral hippocampal sclerosis. Axial FLAIR (c) and oblique coronal FSE T2- weighted (d) images show hyperintense signal involving the head and body of both hippocampi, more evident on the right
Slide 32-

Atrophy of the ipsilateral fornix and mamillary body Increased signal and or atrophy of the anterior thalamic nucleu s Atrophy of the cingulate gyrus Increased signal and / or reduction in volume of the amygdala Reduction in volume of the subiculum Dilatation of temporal horn and temporal lobe atrophy
Slide 33-

Collateral white matter and entorhinal cortex atrophy Thalamic and caudate atrophy Ipsilateral cerebral hypertrophy Contralateral cerebellar hemiatrophy Loss of grey-white matter interface in the anterior temporal lobe Reduced white matter volume in the parahippocampal gyrus
Slide 34-

HIPPOCAMPAL ATROPHY WITH DILATED TEMPORAL HORN Fig. 1. Coronal FLAIR demonstrating atrophy of the right hippocampal head with dilatation of the temporal horn.
Slide 35-

LOSS OF GREY WHITE DIFFERENTIATION Coronal T1WI displaying loss of grey white matter differentiation in the regio n of the right hippocampal head.
Slide 36-

HIPPOCAMPAL AND FORNIX ATROPHY Coronal FLAIR sequences exhibiting atrophy of the right hippocampal body and tail as well as the right fornix.
Slide 37-

Oblique coronal FSE T2-weighted image shows digitation loss in the hippocampal head (arrow). b Left hippocampal sclerosis. Oblique coronal FSE T2-weighted image shows atrophy of ipsilateral mammillary body (arrow).
Slide 38-

c Right hippocampal sclerosis. Oblique coronal FSE T2- weighted image shows thinning of ipsilateral posterior fornix (arrow). Left hippocampal sclerosis. Oblique coronal inversion recovery images. Note enlargement of ipsilateral ventricular temporal horn (asterisk, d), small ipsilateral mammillary body (arrow, d), and narrowed collateral white matter on the left, consistent with atrophy of the hippocampus without apparent signal abnormality.
Slide 39-

SIGNIFICANCE OF SECONDARY FEATURES Important findings related to pathophysiology,diagnosis and prognosis One should think about mesial temporal sclerosis as a process involving diffuse regions of the brain rather than as one limited to the hippocampus. Lateralization of mesial temporal sclerosis. Inpatients with subtle primary findings of unilateral mesial temporal sclerosis, these secondary imaging features help improve diagnostic confidence In bilateral hippocampal abnormalities, secondary findings can determine the more important side to resect.
Slide 40-

THE ATROPHIC-GLIOTIC CHANGES CAN INVOLVE part of the hippocampal formation patchy areas, and extend to the temporal neocortex Structures outside the temporal lobe insula; frontobasal and opercular cortex, a lesion termed pararhinal sclerosis Atrophy of the whole ipsilateral temporal lobe Hippocampal sclerosis can be bilateral
Slide 41-

ppt slide no 41 content not found
Slide 42-

D/D OF HIPPOCAMPAL HYPERINTENSITY Hippocampal hyperintensity on T2WI or FLAIR images with volume loss is diagnostic for mesial temporal sclerosis in the appropriate clinical setting. Hippocampal hyperintensity without volume loss is seen in: Status epilepticus Low grade tumors (astrocytoma, DNET) Encephalitis
Slide 43-

STATUS EPILEPTICUS In status epilepticus a hyperintense hippocampus can be seen, but there is swelling and no atrophy. Axial FLAIR, axial DWI and coronal T2WI demonstrate a hyperintense hippocampus with a slightly compressed temporal horn of the lateral ventricle consistent with hippocampal edema. DWI shows diffusion restriction due to cytotoxic edema in the acute stage of the status epilepticus.
Slide 44-

DNET NET mimicking mesial temporal sclerosis Axial T2WI shows hyperintense, but enlarged hippocampus with a bubbly appearance. This is typical for a DNET or dysembryoplastic neuroepithelial tumor, The coronal contrast-enhanced T1WI shows an enlarged hippocampus without uptake of contrast medium.
Slide 45-

HIPPOCAMPAL VOLUMETRY Requires side-to-side ratios & absolute volumes corrected for intracranial volume, which must be compared with appropriated age- matched controls from the same laboratory Limitations Time-consuming. Relies on subjective definition of the hippocampal boundaries May fail to detect bilateral changes [201]. May be normal in a small subgroup of patients with abnormal signal in one hippocampus as determined by preoperative MRI and pathologically proven HS
Slide 46-

Normally, both hippocampi are of equal volume with a slight prevalence of the right side Any asymmetry greater than 0.3 cm is abnormal Volumetry can detect up to 90% of cases of HS compared to about 80% by visual assessment
Slide 47-

T2 RELAXOMETRY Quantitative MRI may be also used to detect hippocampal Gliosis Actual quantitative measurements of T2 relaxation time through the hippocampal body may permit the recognition of unilateral or bilateral involvement in patients with apparently normal MRI scans obtained by classical techniques
Slide 48-

As a result of neuronal loss, the extra cellular space is enlarged and thus diffusion of water molecules is greater on the affected side, resulting in increased values on the affected side (higher signal on ADC). Conversely, due to neuronal dysfunction and swelling, diffusion is restricted following a seizure, and thus values are lower.
Slide 49-

DTI Diffusion tensor imaging may reveal focal temporal anisotropy in patients with temporal lobe epilepsy
Slide 50-

The NAA decline has been considered to reflect neuronal loss Patients with TLE have reduced NAA in the ipsilateral hippocampus compared with NAA in the contralateral side lateralizing the seizure focus in TLE. Myo-Inositol is found primarily in astrocytes. Elevation of myoinositol would be expected in areas of astroglial cell proliferation Decreased NAA / Cho and NAA / Cr ratios Increased lipid and lactate soon after the seizure
Slide 51-

PET SCAN IN MTE Inter ictal period metabolism in the region of seizure focus decreases compared to normal brain regions. Intra ictal period the seizure focus usually shows abnormally increased metabolism, which can also help identify the location of seizure activity. PET imaging for epilepsy is usually used as a tool for possible surgical candidates.
Slide 52-

PET is of great assistance in lateralizing the seizure focus in patients with temporal lobe epilepsy and a normal MRI Bilateral temporal hypometabolism suggests bilateral temporal pathology and possibly a poorer prognosis following temporal lobe surgery
Slide 53-

Coronal interictal MR/FDG-PET fusion image shows hypometabolic activity in the right temporal pole (arrow).
Slide 54-

SPECT If the radiotracer is injected ictally, focally increased uptake is identified in the affected temporal lobe (hot focus). Interictally, the affected temporal lobe demonstrates decreased uptake compared with that of the rest of the brain (cold focus). Interictal SPECT studies may include a number of false positive and negative results, because the precise time course of the perfusion abnormalities is unknown.
Slide 55-

Ictal SPECT is extremely helpful in the presurgical evaluation of temporal lobe epilepsy in selected patients, especially those in whom ictal EEG data is inconclusive. Interictal SPECT provides useful baseline information for assessing ictal studies, while in isolation is of minimal value
Slide 56-

CONCLUSIONS MRI is the radiological investigation of choice for diagnosing MTS. Familiarity with the regional medial temporal lobe anatomy is important for correct MRI interpretation. Coronal high-resolution FLAIR is the best sequence to diagnose MTS, where hyperintensity and atrophy of the hippocampus are the most sensitive signs.
Slide 57-

THANK YOU