Download Free Medical Hereditary Angioedema: Pathogenesis of Attacks PowerPoint Presentation

Hereditary Angioedema: Pathogenesis of Attacks PowerPoint Presentation

DOWNLOAD MEDICAL POWERPOINT PRESENTATION

About This Presentation

Description : This medical presentation titled "Hereditary Angioedema: Pathogenesis of Attacks" tells us about angioedema and urticaria.

Tags : Hereditary Angioedema, Pathogenesis, Attack, urticaria, HAE, Pathophysiology, Impact, Bradykinin, Permeability, Activation, Endothelial Cells, Bradykinin

Published on : Apr 25, 2021 | Views : 2547 | Downloads : 3

Shareable Url :

Embed Code :

Comment

Transcript

Slide 1-

Hereditary Angioedema: Pathogenesis of Attacks Michael M. Frank, MD Samuel Katz Professor of Pediatrics, Medicine and Immunology Duke University Medical Center
Slide 2-

Conflict of interest 5 companies (Lev, CSL Behring, Jerini, Pharming, Dyax) have completed trials of therapy for HAE. I have consulted for all 5 and have received grants in aid from 2, CSL Behring and Lev. I Chair the DSMB for Dyax
Slide 3-

Angioedema vs Urticaria Angioedema: swelling involving the deep dermis; generally localized; mildly pruritic, rarely burning or painful; lasts hours to several days Urticaria: circumscribed raised erythematous lesions involving the superficial dermis; often generalized usually pruritic; lesions usually vary in size and stage; individual lesions last minutes to hours (usually ≤ 24 hr)
Slide 4-

ppt slide no 4 content not found
Slide 5-

Discovering HAE Pathophysiology
Slide 6-

Mechanism of Action of C1 Inhibitor Serpin: Serine Protease Inhibitor
Slide 7-

Contact Activation Systems Factor XII (Hageman Factor) XIIa, XIIf Complement Clotting Kinin Generating Fibrinolytic Kallikrein C1r, C1s, MASP1,2,3, Alternative Pathway Factor XIa Plasmin Tissue plasminogen activator (t-PA) Functions of C1 Inhibitor
Slide 8-

Activated C1 Binds Four C1INH Molecules C1 = C1q C1r2 C1s2 HAE Pathophysiology Ziccardi RJ. J Immunol. 1982;128:2500-2504. ¯
Slide 9-

The Complement Pathways Lectin Pathway Classical Pathway Alternative Pathway C1q C4 C2 C3 C5 to C9 Lysis MBL C3 (H2O) Factors B, D, Properdin MASP 1,2,3 C1r,C1s C1 Inh // C3 regulatory molecules
Slide 10-

Curd JG, et al. J Exp Med. 1980;152:742-747. Curd JG, et al. Mol Immunol. 1982;19:1365. Contact System Is Activated in HAE Patients
Slide 11-

Han ED, et al. J Clin Invest. 2002;109:1057-1063;. C1-INH Null Mice and Vascular Permeability
Slide 12-

Nussberger J, et al. J Allergy Clin Immunol. 1999;104:1321-1322; with permission. In Vivo Generation of Kinins in HAE
Slide 13-

Factor XII Factor XIIa Prekallikrein Factor XIIf BRADYKININ KALLIKREIN HMW Kininogen B2 Receptor ANGIOEDEMA - C1 inhibitor C1 Inhibitor and the Kinin System
Slide 14-

Actin Stress Fibers VE-Cadherin Nonstimulated Stimulated Sandoval R, et al. J Physiol. 2001;533:433-445 Impact of Bradykinin on Permeability
Slide 15-

Surface Factor XII HMW Kininogen-Prekallikrein Assembly on Initiating Surfaces HMW=high-molecular-weight. Mandle R, et al. Proc Natl Acad Sci. 1976;73:4179-4183.
Slide 16-

Normal plasma Normal plasma Factor XII–deficient plasma HMW-kininogen–deficient plasma Antibody to Factor XII Antibody to HMW-Kininogen Immunoperoxidase Staining of Endothelial Cells Joseph K, et al. Clin Immunol. 1999;92:246-255.
Slide 17-

Factor XII–Dependent Bradykinin Formation HMW=high-molecular-weight. Kaplan AP, et al. J Allergy Clin Immunol. 2002;109:195-209.
Slide 18-

C1-INH Inhibition of Factor XII Autoactivation Weiss R, et al. Blood. 1986;68:239-243. HF=Hageman factor.
Slide 19-

Factor XII Factor XIIa Prekallikrein Kallikrein HMW Kininogen Kallikrein “Feedback” Activation of Factor XII Cochrane CG, et al. J Exp Med. 1973;138:1564-1583. HMW=high-molecular-weight. Surface
Slide 20-

Factor XII Factor XIIa Prekallikrein Factor XIIf BRADYKININ KALLIKREIN HMW Kininogen B2 Receptor ANGIOEDEMA - C1 inhibitor C1 Inhibitor and the Kinin System C1 + C4 C4a+C4b Clot
Slide 21-

Factor XIIf (mg/mL) Reduction of Serum Complement by Factor XIIf Ghebrehiwet B, et al. J Clin Invest. 1983;71:1450-1456.
Slide 22-

ppt slide no 22 content not found
Slide 23-

ppt slide no 23 content not found
Slide 24-

B2 Receptor + Bradykinin ‘NO’ PGE2 TPA Plasminogen Plasmin Endothelial cell Vasodilatation Increased Vascular Permeability ANGIOEDEMA Activation of Endothelial Cells by Bradykinin Zhao Y, et al. Am J Physiol. 2001;280:1821-1829. NO=nitric oxide; PGE2=prostaglandin E2; TPA=tissue plasminogen activator.
Slide 25-

Fields T, et al. J Allergy Clin Immunol. 1983;72:54-60; with permission. Ghebrehiwet B, et al. J Clin Invest. 1983;71:1450-1456. Ex Vivo Generation of Bradykinin
Slide 26-

Endothelial Cell Bradykinin Factor XIIa Factor XII Kallikrein Prekallikrein HMWK Bradykinin B2 Receptor gC1qR u-PAR Zn++ Zn++ Cytokeratin 1 Bradykinin B2 Receptor Joseph K, et al. Thromb Haemostasis. 2004;91:61-70.
Slide 27-

Factor XII Factor XIIa Surface * *Amount of factor XIIa in plasma is <0.01% of factor XII Autoactivation of Factor XII Silverberg M, et al. J Biol Chem. 1980;255:7281-7286.