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Gastrointestinal Drugs PowerPoint Presentation

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Description : Check out this medical PowerPoint presentation titled "Gastrointestinal Drugs" by Karen Ruffin RN, MSN Ed.

This medical PowerPoint presentation is about gastrointestinal drugs, medications used to treat disorders and diseases of the digestive system, including the esophagus, stomach, intestines, liver, gallbladder, and pancreas. These drugs can be used to relieve symptoms such as nausea, vomiting, diarrhea, constipation, abdominal pain, and acid reflux.

Some common types of gastrointestinal drugs include:

Antacids: These drugs neutralize stomach acid and can provide relief from acid reflux, heartburn, and indigestion. Examples include calcium carbonate, magnesium hydroxide, and aluminum hydroxide.
Proton pump inhibitors (PPIs): These drugs reduce the production of stomach acid and are used to treat conditions such as gastroesophageal reflux disease (GERD) and ulcers. Examples include omeprazole, lansoprazole, and esomeprazole.
H2 blockers: These drugs block the action of histamine, which stimulates the production of stomach acid. They are used to treat conditions such as GERD, ulcers, and gastritis. Examples include ranitidine, cimetidine, and famotidine.
Antiemetics: These drugs are used to treat nausea and vomiting caused by various conditions, including chemotherapy, motion sickness, and gastrointestinal infections. Examples include ondansetron, metoclopramide, and promethazine.
Laxatives: These drugs help to relieve constipation by promoting bowel movements. They come in various forms, including bulk-forming agents, osmotic agents, stimulants, and lubricants. Examples include psyllium, magnesium citrate, bisacodyl, and mineral oil.
Antidiarrheals: These drugs are used to treat diarrhea by slowing down the movement of the intestines and reducing the frequency and volume of bowel movements. Examples include loperamide and diphenoxylate with atropine.

It is important to consult with a healthcare professional before taking any gastrointestinal drugs, as some may have side effects or interact with other medications.

Tags : Gastrointestinal Drugs, diseases of the digestive system, disorders of the digestive system, esophagus, stomach, intestines, liver, gallbladder, pancreas, pharmaceuticals, pharmaceuticals PowerPoint presentations

Published on : Jun 23, 2023 | Views : 1736 | Downloads : 0

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Slide 1-

Gastrointestinal Drugs By Karen Ruffin RN, MSN Ed.
Slide 2-

Acid-Controlling Agents
Slide 3-

Acid-Related Pathophysiology The stomach secretes: Hydrochloric acid (HCl) Bicarbonate Pepsinogen Intrinsic factor Mucus Prostaglandins
Slide 4-

Glands of the Stomach Cardiac Pyloric Gastric* * The cells of the gastric gland are the largest in number and of primary importance when discussing acid control
Slide 5-

Cells of the Gastric Gland Parietal cells Produce and secrete HCl Primary site of action for many acid-controller drugs
Slide 6-

Hydrochloric Acid Secreted by the parietal cells when stimulated by food Maintains stomach at pH of 1 to 4 Secretion also stimulated by: Large fatty meals Excessive amounts of alcohol Emotional stress
Slide 7-

Cells of the Gastric Gland (cont'd) Chief cells Secrete pepsinogen, a proenzyme Pepsinogen becomes pepsin when activated by exposure to acid Pepsin breaks down proteins (proteolytic)
Slide 8-

Cells of the Gastric Gland (cont'd) Mucoid cells Mucus-secreting cells (surface epithelial cells) Provide a protective mucous coat Protect against self-digestion by HCl
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Slide 10-

Acid-Related Diseases Caused by imbalance of the three cells of the gastric gland and their secretions Most common: hyperacidity Clients report symptoms of overproduction of HCl by the parietal cells as indigestion, sour stomach, heartburn, acid stomach
Slide 11-

Acid-Related Diseases (cont'd) PUD: peptic ulcer disease GERD: gastroesophageal reflux disease Helicobacter pylori (H. pylori) Bacterium found in GI tract of 90% of patients with duodenal ulcers, and 70% of those with gastric ulcers Combination therapy is used most often to eradicate H. pylori
Slide 12-

Treatment for H. pylori Eight regimens approved by the FDA H. pylori is not associated with acute perforating ulcers It is suggested that factors other than the presence of H. pylori lead to ulceration
Slide 13-

Types of Acid-Controlling Agents Antacids H2 antagonists Proton pump inhibitors
Slide 14-

Antacids: Mechanism of Action Promote gastric mucosal defense mechanisms Secretion of: Mucus: protective barrier against HCl Bicarbonate: helps buffer acidic properties of HCl Prostaglandins: prevent activation of proton pump which results in  HCl production
Slide 15-

Antacids: Mechanism of Action (cont'd) Antacids DO NOT prevent the over-production of acid Antacids DO neutralize the acid once it’s in the stomach
Slide 16-

Antacids: Drug Effects Reduction of pain associated with acid-related disorders Raising gastric pH from 1.3 to 1.6 neutralizes 50% of the gastric acid Raising gastric pH 1 point (1.3 to 2.3) neutralizes 90% of the gastric acid Reducing acidity reduces pain
Slide 17-

Antacids (cont'd) Used alone or in combination
Slide 18-

Antacids: Aluminum Salts Forms: carbonate, hydroxide Have constipating effects Often used with magnesium to counteract constipation Examples Aluminum carbonate: Basaljel Hydroxide salt: AlternaGEL Combination products (aluminum and magnesium): Gaviscon, Maalox, Mylanta, Di-Gel
Slide 19-

Antacids: Magnesium Salts Forms: carbonate, hydroxide, oxide, trisilicate Commonly cause diarrhea; usually used with other agents to counteract this effect Dangerous when used with renal failure —the failing kidney cannot excrete extra magnesium, resulting in hypermagnesemia
Slide 20-

Antacids: Magnesium Salts (cont'd) Examples Hydroxide salt: magnesium hydroxide (MOM) Carbonate salt: Gaviscon (also a combination product) Combination products such as Maalox, Mylanta (aluminum and magnesium)
Slide 21-

Antacids: Calcium Salts Forms: many, but carbonate is most common May cause constipation Their use may result in kidney stones Long duration of acid action may cause increased gastric acid secretion (hyperacidity rebound) Often advertised as an extra source of dietary calcium Example: Tums (calcium carbonate)
Slide 22-

Antacids: Sodium Bicarbonate Highly soluble Buffers the acidic properties of HCl Quick onset, but short duration May cause metabolic alkalosis Sodium content may cause problems in patients with HF, hypertension, or renal insufficiency (fluid retention)
Slide 23-

Antacids and Antiflatulents Antiflatulents: used to relieve the painful symptoms associated with gas Several agents are used to bind or alter intestinal gas and are often added to antacid combination products
Slide 24-

Antacids and Antiflatulents (cont'd) OTC antiflatulents Activated charcoal Simethicone Alters elasticity of mucus-coated bubbles, causing them to break Used often, but there are limited data to support effectiveness
Slide 25-

Antacids: Side Effects Minimal, and depend on the compound used Aluminum and calcium Constipation Magnesium Diarrhea Calcium carbonate Produces gas and belching; often combined with simethicone
Slide 26-

Antacids: Drug Interactions Adsorption of other drugs to antacids Reduces the ability of the other drug to be absorbed into the body Chelation Chemical binding, or inactivation, of another drug Produces insoluble complexes Result: reduced drug absorption
Slide 27-

Antacids: Nursing Implications Assess for allergies and preexisting conditions that may restrict the use of antacids, such as: Fluid imbalances – Renal disease – HF Pregnancy – GI obstruction Patients with HF or hypertension should use low-sodium antacids such as Riopan, Maalox, or Mylanta II
Slide 28-

Antacids: Nursing Implications Use with caution with other medications due to the many drug interactions Most medications should be given 1 to 2 hours after giving an antacid Antacids may cause premature dissolving of enteric-coated medications, resulting in stomach upset
Slide 29-

Antacids: Nursing Implications Be sure that chewable tablets are chewed thoroughly, and liquid forms are shaken well before giving Administer with at least 8 ounces of water to enhance absorption (except for the “rapid dissolve” forms) Caffeine, alcohol, harsh spices, and black pepper may aggravate the underlying GI condition
Slide 30-

Antacids: Nursing Implications Monitor for side effects Nausea, vomiting, abdominal pain, diarrhea With calcium-containing products: constipation, acid rebound Monitor for therapeutic response Notify heath care provider if symptoms are not relieved
Slide 31-

Histamine Type 2 (H2) Antagonists
Slide 32-

H2 Antagonists Reduce acid secretion All available OTC in lower dosage forms Most popular drugs for treatment of acid-related disorders cimetidine (Tagamet) famotidine (Pepcid) ranitidine (Zantac)
Slide 33-

H2 Antagonists: Mechanism of Action Block histamine (H2) at the receptors of acid-producing parietal cells Production of hydrogen ions is reduced, resulting in decreased production of HCl
Slide 34-

H2 Antagonists: Indications GERD PUD Erosive esophagitis Adjunct therapy in control of upper GI bleeding Pathologic gastric hypersecretory conditions (Zollinger-Ellison syndrome)
Slide 35-

H2 Antagonists: Side Effects Overall, less than 3% incidence of side effects Cimetidine may induce impotence and gynecomastia May see: Headaches, lethargy, confusion, diarrhea, urticaria, sweating, flushing, other effects
Slide 36-

H2 Antagonists: Drug Interactions Cimetidine (Tagamet) Binds with P-450 microsomal oxidase system in the liver, resulting in inhibited oxidation of many drugs and increased drug levels All H2 antagonists may inhibit the absorption of drugs that require an acidic GI environment for absorption
Slide 37-

H2 Antagonists: Drug Interactions (cont'd) SMOKING has been shown to decrease the effectiveness of H2 blockers (increases gastric acid production)
Slide 38-

H2 Antagonists: Nursing Implications Assess for allergies and impaired renal or liver function Use with caution in patients who are confused, disoriented, or elderly (higher incidence of CNS side effects) Take 1 hour before or after antacids For intravenous doses, follow administration guidelines
Slide 39-

Proton Pump Inhibitors
Slide 40-

Proton Pump The parietal cells release positive hydrogen ions (protons) during HCl production This process is called the “proton pump” H2 blockers and antihistamines do not stop the action of this pump
Slide 41-

Proton Pump Inhibitors: Mechanism of Action Irreversibly bind to H+/K+ ATPase enzyme Result: achlorhydria—ALL gastric acid secretion is blocked
Slide 42-

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Proton Pump Inhibitors: Drug Effect Total inhibition of gastric acid secretion lansoprazole (Prevacid) omeprazole (Prilosec)* rabeprazole (AcipHex) pantoprazole (Protonix) esomeprazole (Nexium) *The first in this new class of drugs
Slide 44-

Proton Pump Inhibitors: Indications GERD maintenance therapy Erosive esophagitis Short-term treatment of active duodenal and benign gastric ulcers Zollinger-Ellison syndrome Treatment of H. pylori–induced ulcers
Slide 45-

Proton Pump Inhibitors: Side Effects Safe for short-term therapy Incidence low and uncommon
Slide 46-

Proton Pump Inhibitors: Nursing Implications Assess for allergies and history of liver disease pantoprazole (Protonix) is the only proton pump inhibitor available for parenteral administration, and can be used for patients who are unable to take oral medications May increase serum levels of diazepam, phenytoin, and cause increased chance for bleeding with warfarin
Slide 47-

Proton Pump Inhibitors: Nursing Implications Instruct the patient taking omeprazole (Prilosec): It should be taken before meals The capsule should be swallowed whole, not crushed, opened, or chewed It may be given with antacids Emphasize that the treatment will be short term
Slide 48-

Other Drugs sucralfate (Carafate) misoprostol (Cytotec)
Slide 49-

sucralfate (Carafate) Cytoprotective agent Used for stress ulcers, erosions, PUD Attracted to and binds to the base of ulcers and erosions, forming a protective barrier over these areas Protects these areas from pepsin, which normally breaks down proteins (making ulcers worse)
Slide 50-

sucralfate (Carafate) (cont'd) Little absorption from the gut May cause constipation, nausea, and dry mouth May impair absorption of other drugs, especially tetracycline Binds with phosphate; may be used in chronic renal failure to reduce phosphate levels Do not administer with other medications
Slide 51-

misoprostol (Cytotec) Synthetic prostaglandin analog Prostaglandins have cytoprotective activity Protect gastric mucosa from injury by enhancing local production of mucus or bicarbonate Promote local cell regeneration Help to maintain mucosal blood flow
Slide 52-

misoprostol (Cytotec) (cont'd) Used for prevention of NSAID-induced gastric ulcers Doses that are therapeutic enough to treat duodenal ulcers often produce abdominal cramps, diarrhea
Slide 53-

Antidiarrheals and Laxatives
Slide 54-

Diarrhea Abnormal frequent passage of loose stool or Abnormal passage of stools with increased frequency, fluidity, and weight, or with increased stool water excretion
Slide 55-

Diarrhea (cont'd) Acute diarrhea Sudden onset in a previously healthy person Lasts from 3 days to 2 weeks Self-limiting Resolves without sequelae
Slide 56-

Diarrhea (cont'd) Chronic diarrhea Lasts for more than 3 weeks Associated with recurring passage of diarrheal stools, fever, loss of appetite, nausea, vomiting, weight loss, and chronic weakness
Slide 57-

Causes of Diarrhea Acute Diarrhea Bacterial Viral Drug induced Nutritional Protozoal Chronic Diarrhea Tumors Diabetes Addison’s disease Hyperthyroidism Irritable bowel syndrome
Slide 58-

Antidiarrheals: Mechanism of Action Adsorbents Coat the walls of the GI tract Bind to the causative bacteria or toxin, which is then eliminated through the stool Examples: bismuth subsalicylate (Pepto-Bismol), kaolin-pectin, activated charcoal, attapulgite (Kaopectate)
Slide 59-

Antidiarrheals: Mechanism of Action (cont'd) Anticholinergics Decrease intestinal muscle tone and peristalsis of GI tract Result: slowing the movement of fecal matter through the GI tract Examples: belladonna alkaloids (Donnatal), atropine
Slide 60-

Antidiarrheals: Mechanism of Action (cont'd) Intestinal flora modifiers Bacterial cultures of Lactobacillus organisms work by: Supplying missing bacteria to the GI tract Suppressing the growth of diarrhea-causing bacteria Example: L. acidophilus (Lactinex)
Slide 61-

Antidiarrheals: Mechanism of Action (cont'd) Opiates Decrease bowel motility and relieve rectal spasms Decrease transit time through the bowel, allowing more time for water and electrolytes to be absorbed Examples: paregoric, opium tincture, codeine, loperamide (Imodium), diphenoxylate (Lomotil)
Slide 62-

Antidiarrheal Agents: Side Effects Adsorbents Increased bleeding time Constipation, dark stools Confusion, twitching Hearing loss, tinnitus, metallic taste, blue gums
Slide 63-

Antidiarrheal Agents: Side Effects (cont'd) Anticholinergics Urinary retention, hesitancy, impotence Headache, dizziness, confusion, anxiety, drowsiness Dry skin, rash, flushing Blurred vision, photophobia, increased intraocular pressure Hypotension, hypertension, bradycardia, tachycardia
Slide 64-

Antidiarrheal Agents: Side Effects (cont'd) Opiates Drowsiness, sedation, dizziness, lethargy Nausea, vomiting, anorexia, constipation Respiratory depression Bradycardia, palpitations, hypotension Urinary retention Flushing, rash, urticaria
Slide 65-

Antidiarrheal Agents: Interactions Adsorbents decrease the absorption of many agents, including digoxin, clindamycin, quinidine, and hypoglycemic agents Adsorbents cause increased bleeding time when given with anticoagulants Antacids can decrease effects of anticholinergic antidiarrheal agents
Slide 66-

Antidiarrheal Agents: Nursing Implications Obtain thorough history of bowel patterns, general state of health, and recent history of illness or dietary changes, and assess for allergies DO NOT give bismuth subsalicylate to children younger than age 16 or teenagers with chickenpox because of the risk of Reye’s syndrome
Slide 67-

Antidiarrheal Agents: Nursing Implications Use adsorbents carefully in geriatric patients or those with decreased bleeding time, clotting disorders, recent bowel surgery, confusion Anticholinergics should not be administered to patients with a history of glaucoma, BPH, urinary retention, recent bladder surgery, cardiac problems, myasthenia gravis
Slide 68-

Antidiarrheal Agents: Nursing Implications Teach patients to take medications exactly as prescribed and to be aware of their fluid intake and dietary changes Assess fluid volume status, I&O, and mucous membranes before, during, and after initiation of treatment
Slide 69-

Antidiarrheal Agents: Nursing Implications Teach patients to notify their physician immediately if symptoms persist Monitor for therapeutic effect
Slide 70-

Laxatives
Slide 71-

Constipation Abnormally infrequent and difficult passage of feces through the lower GI tract Symptom, not a disease Disorder of movement through the colon and/or rectum Can be caused by a variety of diseases or drugs
Slide 72-

Laxatives: Mechanism of Action Bulk forming High fiber Absorbs water to increase bulk Distends bowel to initiate reflex bowel activity Examples: psyllium (Metamucil) methylcellulose (Citrucel) Polycarbophil (FiberCon)
Slide 73-

Laxatives: Mechanism of Action (cont'd) Emollient Stool softeners and lubricants Promote more water and fat in the stools Lubricate the fecal material and intestinal walls Examples: Stool softeners: docusate salts (Colace, Surfak) Lubricants: mineral oil
Slide 74-

Laxatives: Mechanism of Action (cont'd) Hyperosmotic Increase fecal water content Result: bowel distention, increased peristalsis, and evacuation Examples: polyethylene glycol (GoLYTELY) sorbitol (increases fluid movement into intestine) glycerin lactulose (Chronulac)
Slide 75-

Laxatives: Mechanism of Action (cont'd) Saline Increase osmotic pressure within the intestinal tract, causing more water to enter the intestines Result: bowel distention, increased peristalsis, and evacuation
Slide 76-

Laxatives: Mechanism of Action (cont'd) Saline laxative examples: magnesium sulfate (Epsom salts) magnesium hydroxide (MOM) magnesium citrate sodium phosphate (Fleet Phospho-Soda, Fleet enema)
Slide 77-

Laxatives: Mechanism of Action (cont'd) Stimulant Increases peristalsis via intestinal nerve stimulation Examples: castor oil (Granulex) senna (Senokot) cascara
Slide 78-

Laxatives: Indications Laxative Group Bulk forming Emollient Use Acute and chronic constipation Irritable bowel syndrome Diverticulosis Acute and chronic constipation Softening of fecal impaction; facilitation of BMs in anorectal conditions
Slide 79-

Laxatives: Indications (cont'd) Laxative Group Hyperosmotic Saline Use Chronic constipation Diagnostic and surgical preps Constipation Diagnostic and surgical preps Removal of helminths and parasites
Slide 80-

Laxatives: Indications (cont'd) Laxative Group Stimulant Use Acute constipation Diagnostic and surgical bowel preps
Slide 81-

Laxatives: Side Effects Bulk forming Impaction Fluid overload Emollient Skin rashes Decreased absorption of vitamins Hyperosmotic Abdominal bloating Rectal irritation
Slide 82-

Laxatives: Side Effects (cont'd) Saline Magnesium toxicity (with renal insufficiency) Cramping Diarrhea Increased thirst Stimulant Nutrient malabsorption Skin rashes Gastric irritation Rectal irritation
Slide 83-

Laxatives: Side Effects (cont'd) All laxatives can cause electrolyte imbalances!
Slide 84-

Laxatives: Nursing Implications Obtain a thorough history of presenting symptoms, elimination patterns, and allergies Assess fluid and electrolytes before initiating therapy Patients should not take a laxative or cathartic if they are experiencing nausea, vomiting, and/or abdominal pain
Slide 85-

Laxatives: Nursing Implications A healthy, high-fiber diet and increased fluid intake should be encouraged as an alternative to laxative use Long-term use of laxatives often results in decreased bowel tone and may lead to dependency All laxative tablets should be swallowed whole, not crushed or chewed, especially if enteric coated
Slide 86-

Laxatives: Nursing Implications Patients should take all laxative tablets with 6 to 8 ounces of water Patients should take bulk-forming laxatives as directed by the manufacturer with at least 240 mL (8 ounces) of water
Slide 87-

Laxatives: Nursing Implications Bisacodyl and cascara sagrada should be given with water due to interactions with milk, antacids, and H2 blockers Patients should contact their provider if they experience severe abdominal pain, muscle weakness, cramps, and/ or dizziness, which may indicate fluid or electrolyte loss
Slide 88-

Laxatives: Nursing Implications Monitor for therapeutic effect
Slide 89-

Antiemetic and Antinausea Agents
Slide 90-

Definitions Nausea Unpleasant feeling that often precedes vomiting Emesis (vomiting) Forcible emptying of gastric, and occasionally, intestinal contents Antiemetic agents Used to relieve nausea and vomiting
Slide 91-

VC and CTZ Vomiting center (VC) Chemoreceptor trigger zone (CTZ) Both located in the brain Once stimulated, cause the vomiting reflex
Slide 92-

Mechanism of Action Many different mechanisms of action Most work by blocking one of the vomiting pathways, thus blocking the stimulus that induces vomiting
Slide 93-

Indications Specific indications vary per class of antiemetics General use: prevention and reduction of nausea and vomiting
Slide 94-

Mechanism of Action and Indications Anticholinergic agents (ACh blockers) Bind to and block acetylcholine (ACh) receptors in the inner ear labyrinth Block transmission of nauseating stimuli to CTZ Also block transmission of nauseating stimuli from the reticular formation to the VC Scopolamine Also used for motion sickness
Slide 95-

Mechanism of Action Antihistamine agents (H1 receptor blockers) Inhibit ACh by binding to H1 receptors Prevent cholinergic stimulation in vestibular and reticular areas, thus preventing N&V Diphenhydramine (Benadryl), meclizine (Antivert), promethazine (Phenergan) Also used for nonproductive cough, allergy symptoms, sedation
Slide 96-

Mechanism of Action (cont'd) Neuroleptic agents Block dopamine receptors on the CTZ chlorpromazine (Thorazine), prochlorperazine (Compazine) Also used for psychotic disorders, intractable hiccups
Slide 97-

Mechanism of Action (cont'd) Prokinetic agents Block dopamine in the CTZ Cause CTZ to be desensitized to impulses it receives from the GI tract Also stimulate peristalsis in GI tract, enhancing emptying of stomach contents Metoclopramide (Reglan) Also used for GERD, delayed gastric emptying
Slide 98-

Mechanism of Action (cont'd) Serotonin blockers Block serotonin receptors in the GI tract, CTZ, and VC Dolasetron (Anzemet), granisetron (Kytril), ondansetron (Zofran) Used for N&V for patients receiving chemotherapy and postoperative nausea and vomiting
Slide 99-

Mechanism of Action (cont'd) Tetrahydrocannabinoids (THC) Major psychoactive substance in marijuana Inhibitory effects on reticular formation, thalamus, cerebral cortex Alter mood and body’s perception of its surroundings
Slide 100-

Mechanism of Action (cont'd) Tetrahydrocannabinoids (cont'd) dronabinol (Marinol) Used for N&V associated with chemotherapy, and anorexia associated with weight loss in AIDS patients
Slide 101-

Side Effects Vary according to agent used Stem from their nonselective blockade of various receptors
Slide 102-

Nursing Implications Assess complete nausea and vomiting history, including precipitating factors Assess current medications Assess for contraindications and potential drug interactions
Slide 103-

Nursing Implications Many of these agents cause severe drowsiness; warn patients about driving or performing any hazardous tasks Taking antiemetics with alcohol may cause severe CNS depression Teach patients to change position slowly to avoid hypotensive effects
Slide 104-

Nursing Implications For chemotherapy, antiemetics are often given ½ to 3 hours before a chemotherapy agent Monitor for therapeutic effects Monitor for adverse effects