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Endocannabinoids PowerPoint Presentation

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Description : Power point presentation on Endocannabinoids

Tags : Neurotransmitters,Neuro transmitters

Published on : Apr 17, 2023 | Views : 913 | Downloads : 0

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Endocannabinoids
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ENDROGENOUS, LIPID-BASED NEUROTRANSMITTER Found in all mammals Main Function: Homeostasis AFFECTS MAJOR HOMEOSTATIC FUNCTIONS ENERGY INFLAMMATION SLEEP APPETITE PAIN DEVELOPMENT IMMUNE SUPPORT MEMORY/LEARNING Not fully understood and their importance to homeostasis is understated What are Endocannabinoids
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2-AG (2-ARACHIDONOYLGLYCEROL) ANADAMINE Not “pre-made” Calcium/certain Glutamate & GABA receptors trigger enzymes for production Retrograde Inhibitory TWO TYPES OF ENDOCANNABINOIDS*
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CB1 and CB2 Located on pre-synaptic neurons CB1= CNS (Hippocampus, cingulate gyrus, cerebellum, brainstem, and more) Most abundant receptor in mammalian brain Pain, Appetite, Memory THC binds with cb1 Cb2= mainly PNS (liver, spleen, b-cells, t-cells, etc.) and CNS (microglial cells, etc.) Inflammation receptors
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Binds to both receptors Plays a role in: Mood Memory Appetite Pain relief Blissful state from exercise and meditation Runners high Close to THC in chemical makeup ANANDAMINE
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Much higher concentration in the brain than anandamine Binds to both receptors but especially cb1 Aids in: Locomotion Neuroinflammation after brain injuries Pain sensation (blocked by cb1) Food intake (hypothalamus/forebrain during fasting) Mood Learning and memory 2-AG
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ECS=Anandamine, AG-2, CB1, CB2, and their respective enzymes Not yet fully understood, yet responsible for large portion of body homeostasis support. What we know is just the tip of the iceberg… ENDOCANNABINOID SYSTEM
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Harvard Medical School (Harvard Publishing) https://www.health.harvard.edu/blog/the-endocannabinoid-system-essential-and-mysterious-202108112569 National Library Of Medicine (An Introduction to the endogenous cannabinoid system) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789136/ National Library of Medicine (Cooperative endocannabinoid production by neuronal depolarization and group I metabotropic glutamate receptor activation) https://pubmed.ncbi.nlm.nih.gov/11918654/ Washington State University (Drugs and Behavior 2nd Edition) https://opentext.wsu.edu/biopsychological-effects-alcohol-drugs/chapter/chapter-13-cannabinoids/ Science Direct Review (2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain) https://www.sciencedirect.com/science/article/pii/S0163782717300619 Reed University Endocannabinoid Study https://www.reed.edu/biology/professors/srenn/pages/teaching/web_2006/Ryan.Courtney.Website/index.html Wikipedia Endocannabinoid System https://en.wikipedia.org/wiki/Endocannabinoid_system REFERENCES