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Drugs In Ovulation Induction PowerPoint Presentation

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This medical PowerPoint presentation is about ovulation induction, a medical treatment used to stimulate ovulation in women who have difficulty conceiving due to ovulatory disorders. The use of drugs in ovulation induction can help regulate the menstrual cycle and increase the chances of ovulation and pregnancy.

The most commonly used drugs for ovulation induction include:

Clomiphene citrate: This drug is usually the first-line treatment for ovulation induction. It works by blocking the action of estrogen on the pituitary gland, which stimulates the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), leading to ovulation.
Gonadotropins: These are injectable hormones that directly stimulate the ovaries to produce multiple follicles and eggs. Gonadotropins are more potent than clomiphene citrate and are usually used in women who do not respond to clomiphene citrate or who have more severe ovulatory dysfunction.
Metformin: This medication is used to treat insulin resistance and is often used in women with polycystic ovary syndrome (PCOS), which is a common cause of ovulatory dysfunction.
Letrozole: This is an aromatase inhibitor that is used off-label for ovulation induction. It works by reducing the conversion of androgens to estrogen, leading to increased FSH production and follicular growth.
Bromocriptine: This medication is used to treat hyperprolactinemia, which can cause ovulatory dysfunction. It works by reducing prolactin levels, which can stimulate ovulation.

The use of drugs for ovulation induction should always be supervised by a qualified healthcare provider, as there are potential risks and side effects associated with these medications. Additionally, the success rates of ovulation induction vary depending on the underlying cause of ovulatory dysfunction and other factors such as age and overall health.

Tags : ovulation induction, ovulatory disorders, menstrual cycle, pregnancy, Clomiphene citrate, Gonadotropins, Metformin, Letrozole, Bromocriptine, ovulatory dysfunction, Obstetrics and Gynecology, Obstetrics and Gynecology PowerPoint presentation

Published on : Jun 20, 2023 | Views : 1839 | Downloads : 3

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Slide 1-

Objectives Color index 6: Drugs In Ovulation Induction Recall how ovulation occurs and specify its hormonal regulation Classify ovulation inducing drugs in relevance to the existing deficits Expand on the pharmacology of each group with respect to mechanism of action, protocol of administration, indication, efficacy rate and adverse effects. Kindly check the editing file before studying this document
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Overview Drugs used to induce ovulation1 Antiestrogens (SERMs2) GnRH-agonists D2 receptors agonists Treat polycystic ovarian syndrome (PCOS) Gonadotrophins3 * Most common cause of infertility * Insulin resistance may play a role ??? e.g. Metformin6 Clomiphene Tamoxifen Leuprolin Goserelin HMGs4: Menotropin HCGs5: Pregnyl Bromocreptine The hypothalamus produce GnRH to stimulate pituitary, which produce FSH + LH, they will go to the ovaries to stimulate them to produce estrogen + Progestin which will give negative feedback to pituitary and hypothalamus In ovulation we need more FSH & LH, so we either give drugs that: (1) inhibit the negative feedback ‘Antiestrogens’ or (2) stimulate GnRH release ‘GnRH-agonists’ or (3) mimic the FSH + LH ‘Gonadotrophins’ or (4) we will discuss them later  Progestin Estrogen 1 If the cause of infertility is due to ovarian or testicular failure it can’t be treated. So, these treatments are only used if the ovaries are well functioning but the problem is in ovulation 2 selective estrogen receptors modulators 3 Gonadotrophin = LH & FSH 4 Human Menopausal Gonadotrophin 5 Human Chorionic Gonadotrophin 6 Polycystic ovarian syndrome induce high androgen which will cause acne and hirsutism. Patients also become obese → obesity cause Insulin resistance. Treating insulin resistance by Metformin will highly increase the possibility of pregnancy. We also use Clomiphene for the infertility in case of PCOS
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Antiestrogens 7 don’t forget the most important drugs in PCOS is metphormine (بروف يلدز عادتها يمكن عشر مرات ) 8 The side effects are due to the hormonal changes and not the drug itself; all are reversible
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GnRH-agonists Hypothalamus Pituitary GnRH + GnRH receptor GnRH-agonists Pulsatile Continously9 + - FSH LH Normally: secreted in pulsatile mood مفيش حاجات مهمه في الجزئية دي 9 Normally GnRH has a pulsatile form of secretion; when given continuously it has a paradoxical effect (suppress the GnRH receptors “down regulation” or “tolerance”)
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Ovulation Induction * Both male and female doctors emphasized on the indications of each drug (so please focus on them) hMG = FSH+LH الهمج = فشله hCG= ECG LH سووا ECG له
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Ovulation Induction
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MCQs Q1: 33 years old female who is obese, she was diagnosed with PCOS two years ago. Now, she is trying to have and get pregnant. Which of the following drugs can be helpful in her case to induce ovulation ? A. Leuprolin. B. Menotropin & Pregnyl. C. Bromocriptine. D. Metformin. Q2: 26 years old female who has breast cancer. Her lab investigation shows it is a positive for estrogen receptors, which of the following drugs can be used in her case ? A.Clomiphene. B. Menotropin & Pregnyl. C. Tamoxifen. D. Pulsatile Leuprolin. Q3: Which of the following can be used to treat infertile women due to hypothalamic amenorrhea or 2ndry to GnRH deficiency? A.Clomiphene. B. Menotropin & Pregnyl. C. Continuous Goserelin. D. Pulsatile Leuprolin. Q4: Which of the following can be used to treat infertile women due to pituitary insufficiency or gonadotrophic deficiency? A.Clomiphene. B. Menotropin & Pregnyl. C. Continuous Goserelin. D. Pulsatile Leuprolin. Q5: 7 years old girl who has precocious puberty, Which of following would be helpful in her case? A.Clomiphene. B. Menotropin & Pregnyl. C. Continuous Goserelin. D. Pulsatile Leuprolin. Q6: Which of the following can be used to treat infertile women due to primary anovulation and high level of estrogen ? A.Clomiphene. B. Menotropin & Pregnyl. C. Bromocriptine. D. Pulsatile Leuprolin. Q7: In which day of the cycle, hCG should be given for ovum retrieval ? A. 5th day. B. 5th – 10th day. C. 10th – 12th day. D. Day 21. Q8: 31 years old female who is failed to have a baby for three years. Her lab investigation shows high level of prolactin and low level of FSH & LH and estrogen and progesterone in her plasma. Which one of the following drugs can be helpful in her case to induce ovulation ? A.Clomiphene. B. Menotropin & Pregnyl. C. Bromocriptine. D. Pulsatile Leuprolin. 1) D. 2) C. 3) D. 4) B. 5) C. 6) A. 7) C. 8) C.
Slide 8-

References : 1- 436 doctor’s slides and notes @pharma436 pharma436@outlook.com Your feedback قادة فريق علم الأدوية : اللولو الصليهم & فارس النفيسة الشكر موصول لأعضاء الفريق المتميزين : روان سعد القحطاني أثير الرشيد عبدالرحمن الراشد ليلى مذكور معتز الطخيس