Download Free Medical Diuretic drugs PowerPoint Presentation

Diuretic drugs PowerPoint Presentation

DOWNLOAD MEDICAL POWERPOINT PRESENTATION

About This Presentation

Description : Check out this medical presentation on Pharmacology, which is titled "Diuretic drugs", to know about the diuretic drugs.

Tags : Pharmacology, Diuretic drugs

Published on : Jul 18, 2021 | Views : 2669 | Downloads : 1

Shareable Url :

Embed Code :

Comment

Transcript

Slide 1-

Diuretic drugs Assoc. Prof. Ivan Lambev (itlambev@mail.bg)
Slide 2-

Diuretics exert their effect directly on the kidneys. Most of them lead to electrolyte excretion and consequently to osmotic excretion of water, which increases the 24-hr urine volume.
Slide 3-

ppt slide no 3 content not found
Slide 4-

Salidiuretics (thiazides and their analogues) They increase equivalently Na+ and Cl- excretion (1:1) in distal renal tubules and this increases diuresis. They lead to excretion of 5 to 10% from filtrated Na+ ions and have moderate diuretic action. They can be classified as sulfonamides with free –NH2 group, without antimicrobial activity.
Slide 5-

Salidiuretics (saluretics) Thiazides Hydrochlorothiazide Cyclopenthiazide Thiazide analogues Clopamide Chlorthalidone Vasodilators with antihypertensive effect Indapamide (stimulates synthesis of renal PGs with vasodilating action)
Slide 6-

ppt slide no 6 content not found
Slide 7-

ppt slide no 7 content not found
Slide 8-

Hydrochlorothiazide Chlorthalidone Indapamide 5–10% Indapamide SR (does not have metabolic effects) cardioprotector nephroprotector
Slide 9-

Thiazides have a weak antihypertensive effect because they reduce arterial wall sensitivity to NA (noradrenaline) and AT (Angiotensin). They potentiate significantly the effect of other antihypertensive drugs. Thiazides increase plasma renin levels. Reduction of plasma Sodium and osmolarity leads to “paradoxal” antidiuretic effect in diabetes insipidus.
Slide 10-

Adverse reactions (ARs) of saluretics: Hypokalemia and enhancing therapeutic and toxic effects of CGs, hypochloremic alkalosis, GI disorders, skin rashes and photosensibi- lization, muscle weakness and fatigue, hypo- natremia, hypoglycemia, increased plasma level of uric acids, hypercholesterolemia, impotence. Thiazides decrease GF (glomerul filtration). They reduce plasma volume in pregnant women and decrease fetal oxygenation (PRC: D).
Slide 11-

2. Loop Diuretics
Slide 12-

ppt slide no 12 content not found
Slide 13-

ppt slide no 13 content not found
Slide 14-

Furosemide has p.o. bioavailability 65% and t1/2 30–60 min. It acts on the ascending limb of Henley's loop by increasing urine excretion of Na+, Cl, Mg2+ and Ca2+. Its diuretic effect is achieved in 20–30 min after p.o. administration and lasts 4–6 h. Its effect after i.v. administration begins in 3–5 min and lasts 2 h. In low doses (5 to 10 mg p.o.) furosemide has antihypertensive effect. It does not disrupt GF.
Slide 15-

ppt slide no 15 content not found
Slide 16-

Furosemide – indications: Oedemas of different origin, acute ischemic renal failure (in high DD, together with mannitol), anuria and eclampsia, forced diuresis in acute intoxications, hypertension, resistant cardiac failure. Furosemide enhances the action of antihypertensive drugs and non-depolarazing neuromuscular blockers.
Slide 17-

Furosemide – ARs: Hypokaliemia, skin rashes, hyperglycemia, increased plasma levels of uric acid. In fast i.v. administration – transient hearing disturbances with temporary deafness and orthostatic collapse. Ototoxic risk is increased in co-medicaton with aminoglycosides, cephalosporines, polymyxins, sulfonamides or quinolones.
Slide 18-

3. Carbonic anhydrase inhibitors Acetazolamide inhibits carbonic anhydrase (CA) mainly in proximal tubules. H2O + CO2 CA H2CO3 H2CO3– + H+
Slide 19-

Acetazolamide has weak diuretic action. It significantly enhances urine K+ excretion. The loss of HCO3– anions decreases blood alkaline reserve (for 48–72 h) and causes metabolic acidosis. In this state the drug becomes ineffective. Acetazolamide blocks not only renal CA, but also CA in the ciliary body in the eye (reducing production of eye liquid) and in the brain (facilitates GABA synthesis).
Slide 20-

3% Amiloride Triamterene Spironolactone 4. Potassium- sparing diuretics They have weak diuretic action and save K+. Often they are used in combination with diuretics, causing hypokalemia.
Slide 21-

Potassium-sparing diuretics Competitive aldosterone antagonists: Spironolactone Blockers of the amiloride-sensitive Na+ channels: Amiloride Triamterene
Slide 22-

ppt slide no 22 content not found
Slide 23-

ppt slide no 23 content not found
Slide 24-

Spironolactone is a steroid compound, which is a competitive aldosterone antagonist. It increases Na+ excretion and decreases K+ and urea excretion. Its diuretic action is weak and is achieved slowly. Spironolactone is effective in oedemas, caused by increased production of aldosterone ascites in liver cirrhosis and oedemas in congestive heart failure.
Slide 25-

Spironolactone in low doses (25 mg/24 h) potentiates the effect of ACE inhibitors. It saves K+ and Mg2+ ions and has antiarrhyth- mic effect. It also prevents the development of myocardial fibrosis, caused by aldosterone and in this way contributes to enhancing myocardial contractility.
Slide 26-

Diuretidin® (triamterene/hydrochlorothiazide) is indicated in oedemas cardiac, renal, liver or other origin and for the treatment of hypertension with other antihypertensive drugs. Moduretic® (amiloride/hydrochlorothiazide) has the same indications too.
Slide 27-

60–80% 5. Osmotic diuretics
Slide 28-

After oral administration Mannitol is not absorbed and has laxative effect. After i.v. administration it is not metabolized, it filtrates in the glomerulus and not reabsorbed in renal tubules, causing increased osmotic pressure and excretion of isoosmotic equivalent of water. It increases blood flow in 30%.
Slide 29-

Мannitol does not influence renin synthesis. It does not cross tissue barriers (BBB neither), does not penetrate to the eye and brain and in osmotic way reduces intraocular and intra- cranial pressure. It is included in the treatment of brain oedema, initial stages of acute renal failure, chronic renal failure, glaucoma, intoxications with drugs, excreted in the urine.
Slide 30-

6. Phytodiuretics Rhizoma Graminis (Couch-grass) Stipites Cerasorum (Cherry) Fructus Faseoli sine semine (Haricot) Fructus Petroselini (Parsley) Stigmata Maydis (Maize, corn)
Slide 31-

ppt slide no 31 content not found
Slide 32-

ppt slide no 32 content not found
Slide 33-

ppt slide no 33 content not found
Slide 34-

ppt slide no 34 content not found
Slide 35-

ppt slide no 35 content not found
Slide 36-

ppt slide no 36 content not found
Slide 37-

Rubia tinctorum L. (madder). Radix Rubiae contains 2–3% di- or trioxyanthraquinones glycosides, flavonoids and other bioactive substances with diuretic, urolitholytic and spasmolytic effects. Infusions (1:10) made from madder facilitate dilution of calculi, containing calcium and magnesium sulfate in the renal pelvis and bladder. It is an important ingredient of many phytoproducts (Cystenal©, Rowatinex©), indicated in urolithiasis.