Download Free Medical Challenges of MDR-TB in HIV-infected children PowerPoint Presentation

Challenges of MDR-TB in HIV-infected children PowerPoint Presentation

DOWNLOAD MEDICAL POWERPOINT PRESENTATION

About This Presentation

Description : Challenges of MDR-TB in HIV-infected children.

Tags : Pediatrics, Child Health, pediatric practice, pediatrician, health providers, HIV-infected infants, Adolescent Transition, HIV-infected adolescents, epidemiology, south Africa, nutrition, MDR-TB

Published on : Jul 18, 2020 | Views : 1676 | Downloads : 5

Shareable Url :

Embed Code :

Comment

Transcript

Slide 1-

Challenges of MDR-TB in HIV-infected children H Simon Schaaf Desmond Tutu TB Centre Department of Paediatrics and Child Health, Stellenbosch University, and Tygerberg Children’s Hospital
Slide 2-

Challenges with the numbers Lancet Infect Dis 2016 Estimates for 2014: MDR-TB numbers based on model and numbers reported to Global Project on Antituberculosis Drug Resistance Surveillance at WHO and from surveys and surveillance reported between 1988 and 2014 850 000 children with TB 58 000 children INH mono-resistant TB 25 000 children MDR-TB 1 200 children XDR-TB Infected with MDR-TB - 2 million children
Slide 3-

DR-TB more common in HIV-infected children? No definite data in children From our 2-year surveillance periods since 2003 we could not show a difference per 2-year period However, with 14 yrs of data available in 2112 children (<13 years) with culture-confirmed TB: and both HIV status & DST known in 1738 (82.3%): Significantly more MDR/RIF resistance in HIV- infected children compared to HIV-uninfected but no difference in INH mono-resistance
Slide 4-

ppt slide no 4 content not found
Slide 5-

Challenges with MDR-TB diagnosis Does the child have TB disease? exclude infection only (may even be Xpert or culture-positive) exclude other conditions – more common in HIV- infected children / may co-exist with TB Need to bacteriologically confirm TB and DR-TB whenever possible obtain specimen for TB bacteriology BEFORE starting treatment (excl. in TBM/miliary TB) do DST on ALL (HIV-infected) children with a positive culture for M. tuberculosis
Slide 6-

Diagnosis : MDR-TB in children DR TB is a microbiological diagnosis In children often difficult (paucibacillary TB): Confirmed if DR M. tuberculosis strain is isolated from a child Probable DR-TB if there is known contact with an infectious adult DR-TB case (>78-90% concordance in several studies) Suspect DR-TB if: # a child gets worse on Rx, failing adherent Rx # an adult source case who has no DST-result is a treatment failure, a retreatment case or died of TB during adherent Rx
Slide 7-

Culture vs. Xpert MTB/RIF
Slide 8-

Challenges with DR-TB treatment “Rapidly” changing scene!? Dose-finding and safety studies for existing 2nd-line drugs, new and repurposed drugs – correct doses & safety important for HIV co-infected children on ART New shorter 9-12 month regimen recently approved by WHO for RIF-mono and strictly MDR-TB cases (4-6hdH/Eto/Mxf/Cfz/Km/Z/E+5-6Mfx/Cfz/Z/E) – limited application in SA context (need rapid 2nd-line DST – GenoType MTBDRsl LPA now approved) Many shortened/new regimens currently studied in adults: if it has efficacy in adults, then only need dose & safety evaluation in children
Slide 9-

Slide: courtesy Anthony Garcia-Prats
Slide 10-

Challenges in DR-TB treatment/ART WHO 2016 guidelines: ART is recommended for all patients with HIV and DR-TB requiring second-line anti-TB drugs irrespective of CD4 cell count, as early as possible (within the first 8 weeks) following initiation of anti- TB treatment (strong recommendation, very low- quality evidence). However: Early initiation of ART in TBM has a risk of intracranial IRIS – may be fatal. Usually treat TB a few weeks before starting ART. If ART started early – be aware of signs of raised intracranial pressure
Slide 11-

Drug-drug interactions WHO guidelines 2016: The complexity of ARV regimens and second-line TB treatment, each with its own toxicity profiles and some of which may be potentiated by concomitant therapy, demands rigorous clinical monitoring. Drug-drug interactions: Few known with 2nd-line drugs – pharmacovigilance NB Delamanid – no known DDIs of importance Bedaquiline – LPV/r increases Bdq and M2 (metabolite) exposure; EFV may reduce Bdq exposure by 50%: Needs further evaluation regarding relevance New ARVs such as integrase inhibitors – seem safe with second-line anti-TB drugs
Slide 12-

ppt slide no 12 content not found
Slide 13-

ppt slide no 13 content not found
Slide 14-

Challenges with drug administration ARVs and MDR-TB treatment together – often also supplements, treatment of other conditions Child-friendly formulations of second-line anti-TB drugs rarely available – being addressed slowly Currently all children co-infected with MDR-TB/HIV receive a daily second-line injectable agent – clinic staff often refuse to administer – often hospitalised
Slide 15-

Challenges with Adverse Effects Similar toxicities, e.g mitochondrial toxicity to be considered with Lzd, Bdq and NRTI’s/NNRTI’s Adverse effects of DR-TB Rx reported to be more common in HIV-infected children Need to develop injectable-sparing regimen for MDR-TB treatment
Slide 16-

Alphabetical Toxicity list – which drug causes what? Arthralgia/arthritis: FQNs/PZA/RFB Blood dyscrasias: INH/RIF/PZA/LZD/FQNs/PAS and more Central nervous system toxicity: headache, drowsiness, seizures, weakness, insomnia, hallucinations: FQNs Depression/Psychosis: INH/ETO/TZD Endocrine effects – hypothyroidism: PAS/ETO, gynaecomastia: ETO/INH Flu-like syndrome: RIF/RFB/PAS GIT disturbances – nausea, vomiting, abdominal pain, diarrhoea: Many! ETO/PAS/FQNs/CFZ/LZD/BDQ Expert Opinion Drug Safety – Schaaf et al – in press
Slide 17-

Alphabetical Toxicity List – which drug does what? Hearing impair/ototoxicity: AM/KM/CM Hair loss (alopecia): INH/ETO Idiopathic intracranial pressure: FQNs Jaundice/hepatotoxicity: PZA/INH/RIF/ETO/PAS/MFX K+ decrease: Electrolyte disturbance : CM/PAS Lactic acidosis: LZD Myelosuppression: LZD Nephrotoxicity: AM/KM/CM/SM Optic neuritis/vision disturbance/colour blindness: EMB/LZD/INH/ETO/PAS Expert Opinion Drug Safety – Schaaf et al – in press
Slide 18-

Alphabetical Toxicity list – which drug causes what? Peripheral neuropathy: INH/ETO/LZD/TZD Pancreatitis: LZD QTc interval prolongation: FQN/CFZ/CLA/BDQ/DLM Rashes: PZA/FQNs/TZD/PAS and many other Skin discolouration – red skin: CFZ Tendinitis/tendonopathy: FQNs Uveitis: RFB Vestibular toxicity: AM/KM/CM/SM Expert Opinion Drug Safety – Schaaf et al – in press
Slide 19-

59/325 (18%) were HIV-infected children – no influence on mortality Lancet Infect Dis. 2012 Own experience is that HIV-infected children do have higher mortality
Slide 20-

The Challenge of Prevention Appropriate TB infection control measures in all facilities caring for people with HIV and efforts to optimize adherence and completion of TB treatment are important to help reduce the incidence of MDR- TB. (WHO 2016) To effectively “bend the curve” (accelerate decline in TB incidence)—will require not only finding and treating those with TB, but will also require treating those with TB infection who may become sick in the future. (Dye C, et al. Prospects for tuberculosis elimination. Annu Rev Public Health 2013;34:271-286.) - this should include those with DR-TB infection
Slide 21-

Including: Vaccine, Treatment of TB disease and infection New diagnostics and healthcare for all
Slide 22-

ppt slide no 22 content not found
Slide 23-

Preventing MDR/XDR-TB WHO does not support drug treatment for prevention of MDR-TB – according to “Grade” system, too little data No RCT to support MDR-TB preventive therapy, but many good observational studies (prospective and retrospective) have shown that MDR-TB is preventable and preventive treatment is safe
Slide 24-

Seddon JA, Fred D, Amanullah F, Schaaf HS, Starke JR, Keshavjee S, Burzynski J, Furin JJ, Swaminathan S, Becerra MC. (2015) Post-exposure management of multidrug-resistant tuberculosis contacts: evidence-based recommendations. Policy Brief No. 1. Dubai, United Arab Emirates: Harvard Medical School Center for Global Health Delivery–Dubai.
Slide 25-

Challenge: To prevent MDR/XDR-TB This policy brief followed from a meeting of >50 TB practitioners from 19 countries on MDR-TB prevention The current evidence base is 10 observational studies (published and unpublished), including >600 contacts treated for presumed MDR-TB infection – all studies showed success in preventing MDR-TB in contacts The group felt strongly that the time for MDR-TB preventive treatment has come Fluoroquinolone-based preventive regimen preferred However – RCTs to confirm efficacy should go ahead Prevention of XDR-TB remains a problem – new drugs?
Slide 26-

The challenges are ours to find solutions! Acknowledgements for Financial Support: SA National Research Foundation; NIH

User Presentation
Related Presentations

Neuropsychological performance in African children with HIV enrolled in a multi-site anti-retroviral clinical trial

By: MarieAltmann
Views: 1673

Every Newborn: WHO action plan to end preventable deaths

By: MarieAltmann
Views: 2126

Translating Developmental Science into Healthy Lives

By: MarieAltmann
Views: 1745

Prenatal Pediatrics

By: MarieAltmann
Views: 2382

Pediatric Drug Pipeline: New Drugs, New Strategies

By: MarieAltmann
Views: 1713

Skenario Gnaps

By: wira0511gmail.com
Views: 1540

Children and COVID-19: State-Level Data Report

By: MarieAltmann
Views: 1669

Pediatrics - Respiratory Emergencies

By: drdwayn
Views: 3575

Normal Pregnancy

By: havefaith15
Views: 1406

Pediatric Pharmacology - Steriods

By: JenniferDwayne
Views: 1618

MarieAltmann

About : I am a passionate Pediatrician with experience of working in world-renowned hospital systems as well as community-based clinics. I have skills like Advocacy, Team Building, Event Planning, and Public Speaking. A dedicated and worthy healthcare services professional with a MPH focused in International studies from Tulane School of Public Health and Tropical Medicine.
Occupation : Medical Professional
Specialty : MD
Country : United States of America
Website :

HEALTH A TO Z