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Cardiac Pacemakers PowerPoint Presentation

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Description : Check out this medical presentation on Pacemaker, which is titled "Cardiac Pacemakers", to know about the cardiac pacemakers, an electric simulator that produces periodic electric pulses that are conducted to electrodes terminated within the lining of the heart.

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Published on : Jul 01, 2021 | Views : 5705 | Downloads : 47

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BME 312 BIOMEDICAL INSTRUMENTATION II LECTURER: ALİ IŞIN LECTURE NOTE 1 CARDIAC PACEMAKERS BME 312-BMI II-L1- ALİ IŞIN 2015 FACULTY OF ENGINEERING DEPARTMENT OF BIOMEDICAL ENGINEERING
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Cardiac Pacemakers BME 312-BMI II-L1- ALİ IŞIN 2015
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Cardiac Pacemakers BME 312-BMI II-L1- ALİ IŞIN 2015
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Cardiac Pacemakers An electric simulator that produces periodic electric pulses that are conducted to electrodes terminated within the lining of the heart. The stimulus thus conducted to the heart causes it to contract. Used during disease states in which the heart is not stimulated at a proper rate on its own. BME 312-BMI II-L1- ALİ IŞIN 2015
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Development of Cardiac Pacemakers The practical use of an implantable device for delivering a controlled, rhythmic electric stimulus to maintain the heartbeat is relatively recent: Cardiac pacemakers have been in clinical use only slightly more than 50 years. Although devices have gotten steadily smaller over this period (from 250 grams in 1960 to less than 25 grams today and even smaller to the size of a AAA battery with recent leadless designs ), the technological evolution goes far beyond size alone. Early devices provided only single-chamber, asynchronous, nonprogrammable pacing coupled with questionable reliability and longevity. Today, advanced electronics afford dual-chamber multi programmability, diagnostic functions, rate response, data collection, and exceptional reliability, and lithium-iodine power sources extend longevity to upward of 10 years. And recently , complications and problems faced with the need of a surgical pocket for implantation of the device and the application of lead systems forced scientist to propose/develop leadless cardiac pacemakers.
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As a world first, a leadless cardiac pacemaker developed by St. Jude Medical (called Nanostim, which has one-tenth the size of existing cardiac pacemakers) is implanted into a patient in USA on early February 2014. After St. Jude Medical (end of February 2014), another well known pacemaker company Medtronic repeated the same milestone by implanting its own leadless pacemaker (Micra, which they claim to be the world’s smallest)into a patient.
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Asynchronous Pacemakers An asynchronous pacemaker is one that is free running. Its electric stimulus appears at a uniform rate regardless of what is going on in the heart. BME 312-BMI II-L1- ALİ IŞIN 2015
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Asynchronous Pacemakers The oscillator establishes the pulse rate for the pacemaker The pulse rate controls the pulse output circuit that provides the stimulating pulse to the heart. The pulse is conducted along the lead wires to the cardiac electrodes. BME 312-BMI II-L1- ALİ IŞIN 2015
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Requirements Each block must be highly reliable The package of an implanted pacemaker Must be compatible and well tolerable by the body. Must provide the necessary protection to the circuit components to ensure reliability. Must be designed to operate well in the corrosive environment of the body Must occupy minimal volume or mass. BME 312-BMI II-L1- ALİ IŞIN 2015
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Cardiac Pacemakers-Design They are packaged in hermetically (airtight) sealed metal packages. Titanium Stainless steel Special electron beam or laser welding techniques are used to seal these packages without damaging the electronic circuit or the power source. Metal packages takes less volume and are more reliable than polymer-based packages. BME 312-BMI II-L1- ALİ IŞIN 2015
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Power Supply Battery made up of primary cells were used in 1970s. Required replacement in every two years. Currently Lithium Iodide batteries are used Increased life time Open circuit voltage of 2.8 V. Highly reliable Relatively High source resistance is a major limitation. BME 312-BMI II-L1- ALİ IŞIN 2015
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Timing Circuit Implemented by free running oscillators Advanced pacemakers have timing circuits to determine when a stimulus should be applied to the heart. Complex logic circuits, quartz crystal control & Microprocessor based circuits are in use today. BME 312-BMI II-L1- ALİ IŞIN 2015
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Output Circuit/Pulse Generator Produces the actual electrical stimulus that is applied to the heart. Generates an electrical stimulus pulse that has been optimized for stimulating the myocardium through the electrode system that is being applied with the generator. Constant-voltage or constant-current amplitude pulses are the two usual types of stimuli produced by the output circuit. BME 312-BMI II-L1- ALİ IŞIN 2015
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Output Circuit… Constant-voltage amplitude pulses are typically in the range of 5.0 to 5.5 V with a duration of 500 to 600 µs. Constant-current amplitude pulses are typically in the range of 8 to 10 mA with a pulse duration ranging from 1.0 to 2.0 ms. Pulse rates ranges from 70 to 90 beats per minute. BME 312-BMI II-L1- ALİ IŞIN 2015
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Lead Wires & Electrodes Requirements: Must be mechanically strong Must be able to withstand constant motion of the beating heart. Must maintain good electrical insulation to prevent the possibility of shunting important stimulating current away from its intended point of application on the heart. BME 312-BMI II-L1- ALİ IŞIN 2015
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Lead Wires & Electrodes… Consists of interwound helical coils of spring-wire alloy molded in a silicone-rubber or polyurethane cylinder. The helical coiling of wire minimizes the stress applied to it. Multiple strands serve as insurance against failure of the pacemaker following rupture of a single wire. The soft compliant silicone rubber encapsulation both maintains flexibility of the lead-wire assembly and provides electrical insulation and biological compatibility. BME 312-BMI II-L1- ALİ IŞIN 2015
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Bipolar & Unipolar electrodes Unipolar A single electrode is in contact with the heart, and negative-going pulses are connected to it from the generator. A large indifferent electrode is in contact located somewhere else in the body, usually mounted on the generator, to complete the circuits. Bipolar In the bipolar system, two electrodes are placed within or on the heart, and the stimulus is applied across these electrodes. BME 312-BMI II-L1- ALİ IŞIN 2015
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Electrodes Can be placed on the external surface of the heart (epicardial electrodes) or Buried within the heart wall (intramyocardial electrodes) or Pressed against the inside surface of the heart (endocardial or intraluminal electrodes) BME 312-BMI II-L1- ALİ IŞIN 2015
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Electrodes Made of materials that do not Dissolve during long term implantation Cause undue irritation to the heart tissue adjacent to them Undergo electrolytic reactions when stimulus is applied. Made of same materials as the lead wire to avoid junctional problems. A dense capsule formation around electrode is made to minimize biological interaction. To increase the threshold required for stimulation. BME 312-BMI II-L1- ALİ IŞIN 2015
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Electrodes… Materials used are: Platinum Alloys of platinum with stainless steel, carbon, and titanium, etc… BME 312-BMI II-L1- ALİ IŞIN 2015
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Bipolar intraluminal & Intramyocardial electrodes BME 312-BMI II-L1- ALİ IŞIN 2015
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The conducting bands around the circumference of the solid intraluminal probe contact the internal surface of the heart wall and electrically stimulate it. The intramyocardial electrode is placed on the exterior surface of the heart. A puncture wound is made in the wall of the heart, and the helical spiral-shaped electrode is placed in the this hole. To hold the electrode in place, the silicone-rubber supporting piece is then sutured to the external surface of the heart. Bipolar intraluminal & Intramyocardial electrodes BME 312-BMI II-L1- ALİ IŞIN 2015
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This flexible back support provides a good mechanical match between the electrode and the heart wall. For bipolar intramyocardial stimulation, a pair of these electrodes is attached to the myocardium. Bipolar intraluminal & Intramyocardial electrodes BME 312-BMI II-L1- ALİ IŞIN 2015
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intraluminal electrodes / transvenous pacemaker BME 312-BMI II-L1- ALİ IŞIN 2015
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Demand-type Synchronous Pacemaker BME 312-BMI II-L1- ALİ IŞIN 2015
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It has a feedback loop. After each stimulus the timing circuit reset itself. Waits for a predetermined interval to provide the next stimulus. If during this interval, a natural beat occurs in the ventricle, the feedback circuit amplifies it and this signal will reset the timer. Demand-type Synchronous Pacemaker BME 312-BMI II-L1- ALİ IŞIN 2015
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Rate-Responsive Pacemaker BME 312-BMI II-L1- ALİ IŞIN 2015
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Includes a control system A sensor is used to convert a physiological variable in the patient to an electric signal that serves as an input to the controller circuit. The controller circuit is programmed to control the heart rate on the basis of the physiological variable that is sensed. The controller can determine whether any artificial pacing is required and can keep the pacemaker in a dormant state when the patient’s natural pacing system is functional. Rate-Responsive Pacemaker BME 312-BMI II-L1- ALİ IŞIN 2015
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The sensor can be located Within the pacemaker itself At some other point within the body. Connected to the pacemaker by a lead-wire system Rate-Responsive Pacemaker… BME 312-BMI II-L1- ALİ IŞIN 2015
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Physiological variables that have been sensed by Rate-Responsive Pacemakers. BME 312-BMI II-L1- ALİ IŞIN 2015
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Leadless Pacemaker;why ? While conventional pacemakers can improve a patient’s quality of life and may even prolong it, physicians and patients have long asked for a pacemaker that does not require an unsightly surgical pocket that may restrict a patient’s mobility or become infected. They also want a solution that eliminates leads, which in rare cases may fail or dislodge.
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Conventional pacemakers require the doctor to make a surgical incision in the chest where a pacemaker permanently sits in a pocket under your skin. The doctor then implants thin insulated wires – which are called leads - from the pacemaker through the veins into your heart. These leads deliver electrical pulses that prompt your heart to beat at a normal rate.
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Although the incidence of pacemaker complications is relatively low (about 4%), when complications occur, they typically happen in the pocket where the pacemaker is implanted or with the leads. In about 1% of patients, the pocket may become infected. In about 3% of patients, the leads may move out of place causing complications.
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While rare, complications can have a serious impact on a patient’s quality of life and also can be expensive to address. Even if complications do not occur, all patients have a scar and lump where pacemaker is implanted. In addition, previous research has shown that as many as six out of 10 patients experience reduced mobility in the shoulder region where the pacemaker is implanted
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With the development of leadless pacemakers, the surgical pocket and leads are eliminated, which means reducing the risks associated with these complications. Other possible advantages of the leadless pacemaker include no visible pacemaker device under a patient's chest skin, no incision scar on the chest and no restrictions on a patient's activities. The device's benefits may also allow for less patient discomfort, infections, and device complications and dysfunction. In addition, the free-standing, battery-operated pacemaker device is designed to be fully retrievable from the heart.
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Leadless Pacemaker Design Similar to standard cardiac pacemakers, leadless pacemaker device treats a heart rate that is too slow called bradycardia. It works by closely monitoring the heart's electrical rhythms and if the heart beat is too slow (or in an irregular pattern) it provides electrical stimulation therapy to regulate it. It also communicates to a programming system (using RF signals), like a standard pacemaker
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Unlike standard pacemakers, leadless pacemaker is designed as a small cylindrical pacemaker. The device is comprised of a pulse generator that includes computer chips, small long lived battery in a sealed case that resembles a AAA battery and a steroid-eluting electrode that sends pulses to the heart when it recognizes a problem with the heart’s rhythm.
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The device, resembling a small, metal silver tube, is only a few centimeters in length, making it less than ten percent the size of a standard pacemaker. But, unlike standard pacemakers, it resides entirely in the right ventricle of your heart. This pacemaker requires no leads, no chest incision, no scar and no permanent lump under the skin where the pacemaker sits. The pacemaker battery life is equivalent to that of similar standard single chamber pacemakers.
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Leadless Pacemaker Implantation A catheter that contains the leadless pacemaker is passed through a small puncture in the groin and then into the femoral vein. 2. Using X-ray images as a guide, the doctor guides the catheter to the right atrium of the heart and through the tricuspid valve. 3. The catheter with the pacemaker is then guided into the right ventricle. 4. The doctor carefully places the pacemaker and secures it to the wall at the bottom of the right ventricle. 5. The pacemaker is then tested to ensure it is secured to the wall and programmed correctly. 6. The catheter is removed and the pacemaker stays within the right ventricle.