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CARCINOMA CERVIX PowerPoint Presentation

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Description : Check out this medical presentation on cancer titled "CARCINOMA CERVIX" to know about carcinoma cervix, its spread, staging, diagnosis of carcinoma cervix, complications caused by carcinoma cervix, and, its prevention and treatment.

Tags : Cancer, carcinoma cervix, spread, staging, diagnosis, complications, prevention, treatment, Fibroid polyp, Chronic inversion, uterus, Cervical Tuberculosis, Cervical ectopic pregnancy

Published on : May 05, 2021 | Views : 2735 | Downloads : 1

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CARCINOMA CERVIX
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CARCINOMA CERVIX : SPREAD Direct Vagina Uterus Parametrium Lymphatic Primary nodes Obturator Internal & External Iliac Sacral Secondary nodes Common Iliac Para-aortic Inguinal Haematogenous Lungs Liver Bone
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CARCINOMA CERVIX : STAGING Staging is clinical Investigations permitted Cystoscopy / Proctoscopy Intra-venous Urography X-ray chest Imaging studies (USG / CT / MRI) Preinvasive carcinoma Stage 0 : Carcinoma in situ Not to be included in therapeutic statistics
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CARCINOMA CERVIX : STAGING OF INVASIVE DISEASE Stage I : Carcinoma confined to the cervix (Extension to the corpus should be disregarded) Stage Ia : Invasive carcinoma diagnosed only by microscopy Stage Ia1: Minimal microscopic stromal invasion, maximum depth 3mm from basement membrane Stage Ia2: Microscopic stromal invasion > 3mm from basement membrane, but less than 5mm. Maximum horizontal spread < 7mm. Larger lesions should be staged Ib Stage Ib : Invasive carcinoma confined to the cervix, greater than Ia2 whether seen clinically or not Stage Ib1 : Preclinical lesions greater than Ia2 or clinical lesions not exceeding 4cm in size Stage Ib2 : Clinical lesions > 4 cm in size
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CARCINOMA CERVIX : STAGING OF INVASIVE DISEASE Stage II : The carcinoma extends beyond the cervix and uterus but not to the lateral pelvic wall or to the lower 1/3 of the vagina Stage IIa : No obvious parametrial involvement Stage IIb: Obvious parametrial involvement
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CARCINOMA CERVIX : STAGING OF INVASIVE DISEASE Stage III : The carcinoma extends to the lateral pelvic wall, or to the lower 1/3 of the vagina, or causes Hydronephrosis or non-functioning Kidney Stage IIIa: The carcinoma involves the lower 1/3 of the vagina. No extention to the lateral pelvic wall Stage IIIb: The carcinoma extends to the lateral pelvic wall, or causes Hydronephrosis or non functioning kidney
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CARCINOMA CERVIX : STAGING OF INVASIVE DISEASE Stage IV : The carcinoma extends beyond the true pelvis or has clinically involved the mucosa of the bladder or rectum (biopsy proven) A bullous edema of the bladder / rectal mucosa as such, does not permit a case to be allotted to Stage IV Stage IVa: Spread of carcinoma to adjacent organs Stage IVb: Spread of carcinoma to distant organs
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Diagnosis of carcinoma cervix Preclinical (Stage Ia & some patients of Stage Ib1 with absence of obvious growth) Asymptomatic Detected on screening If microinvasion is detected on targeted biopsy or endocervical curettage, a conization of the cervix is mandatory to exclude the presence of invasive carcinoma
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Diagnosis of carcinoma cervix Clinical (Stage Ib1 onwards) Early symptoms Abnormal bleeding Post coital Inter-menstrual Post-menopausal Abnormal discharge Blood stained Dirty Foul smelling Late symptoms Pelvic pain Urinary symptoms Rectal symptoms
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Diagnosis of carcinoma cervix Signs Abnormal area / growth on cervix Induration Friability Bleeding on touch Fixity Confirmation of diagnosis Diagnosis is confirmed by Histopathological examination of the biopsy sample
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Differential diagnosis Fibroid polyp Chronic inversion of the uterus Cervical Tuberculosis Cervical ectopic pregnancy
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Complications Pyometra Haemorrhage Pyelonephritis Vesico-vaginal fistula Uraemia Recto-vaginal fistula
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Prognosis Staging Histologic type Differentiation Tumor volume Lymph node involvement
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Cause of death Uraemia Haemorrhage Sepsis
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Prevention of Carcinoma cervix Health education Avoid early marriage Avoid early intercourse Avoid promiscuity Proper hygiene Use of barrier contraception Screening programs Screening for pre-malignant lesions Screening for early diagnosis
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Investigations For confirmation of diagnosis Biopsy From obvious growth or abnormal area Directed biopsy in very early lesions Cone biopsy For staging of disease Intravenous Urography Abdominal Ultrasonography Cystoscopy Proctosigmoidoscopy Examination under anaesthesia (EUA) CT / MRI Base line investigations of general condition
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Treatment Factors Stage of disease Age of patient General condition / Associated problems Tumor configuration Modalities Surgery Radiotherapy Combined Chemo-radiation
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Surgery for Carcinoma cervix Curative surgery can be performed in Ca Cx upto Stage IIa Surgery is preferred in Young patients Patients with prolapse Patients with uteri distorted by fibroids Co-existing pelvic pathology Stage Ia1 disease Conization may be both diagnostic and therapeutic Simple extra fascial hysterectomy
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Surgery for Carcinoma cervix Stage Ia2  IIa disease Wertheim’s / Meig’s hysterectomy (Extended hysterectomy with pelvic lymphadenectomy) Uterus including cervix Adnexae (Ovaries spared in the young) Wide resection of the parametrium Removal of vaginal cuff Dissection of peri-ureteral tissues Pelvic lymphadenectomy Stage IV a disease Exenteration
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Surgery for Carcinoma cervix Advantages Preservation of ovarian function Preservation of vaginal function Lesser long term morbidity Complications correctable Complications Haemorrhage Infection Lymphocyst formation Ureteric injury / fistula Traumatic Ischaemic Bladder injury Neurogenic bladder dysfunction
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Radiotherapy for Carcinoma cervix Advantages Applicable for all stages of disease As effective as surgery in early stages Lesser primary mortality and immediate morbidity as compared to surgery Preferred in patients unfit for surgery because of medical conditions or extreme obesity Techniques Brachytherapy Teletherapy
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Brachytherapy Radiation sources placed adjacent to the tumor by means of intra-uterine tandems and vaginal colpostats Inverse square law : The dose of radiation at any given point is inversely proportional to the square of the distance from the source of the radiation The dose decreases rapidly as the distance from the applicator increases Personnel protected by afterloading techniques Computerized dosimetry plots isodose curves by taking into account tumor geometry and placement of radiation sources Brachytherapy helps in achieving central control of the tumor
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Brachytherapy Point A It is a paracervical area located 2 cm lateral to the cervical canal and 2 cm above the external os It corresponds to the crossing of the ureters under the uterine artery Adequate summated dose to point A to achieve central control of the tumor is ~ 7500 – 8000 cGy Point B It is located 3 cm lateral to point A on the same horizontal plane It corresponds to the site of the Obturator lymph nodes on the lateral pelvic wall The prescribed dose to point B is 4500 – 6000 cGy depending upon the bulk of parametrial and side wall disease
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Techniques of Brachytherapy Low dose radiation (LDR) Paris technique One application : 120 hrs Manchester technique Two applications : 72 hrs each repeated after 7 days Stockholm technique Three applications : 24 hrs each at weekly intervals High dose radiation (HDR) Five fractions of 700 cGy each to Point A daily
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Teletherapy Radiation is directed towards tumor tissue from external sources like Cobalt 60, Caesium 137 or Linear accelerators Usual dosage is 900 cGy / week in 5 fractions of 180 cGy each, given with or without central shielding Teletherapy is usually given by parallel opposing fields or multiple external fields to decrease damage to normal tissues
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Complications of radiotherapy Radiation damages adjacent normal pelvic tissues in addition to malignant cells Ideal radiation treatments aims to achieve a delicate balance between complete tumor kill without exceeding the tolerance dosage for normal tissues The dose limiting tissues within the pelvis are the rectum, bladder and any loops of the small intestine within the radiation field The radiation dosage to the bladder and rectum should be kept less than 6000 cGy
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Complications of radiotherapy Radiation effects may be immediate or delayed Immediate effects are inflammation and ulceration Delayed effects may appear after months or years Delayed effects are due to ischaemic endarteritis. These effects are progressive, irreversible and dose dependant Vagina, Bladder and Rectum are effected with fibrosis, stricture, vasculitis and fistula formation
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Combined surgery and radiotherapy Minimal role, except in bulky endophytic lesions (Stage Ib2 and IIa) Long term survival is not improved using combined radiotherapy and surgery Complications of combined radiotherapy and surgery are higher
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Combined surgery and radiotherapy Role only in bulky endophytic lesions (Stage Ib2 and IIa) Bulky lesions outgrow their vascular supply and are hypoxic in the centre. The central portions of such tumors are relatively radioresistant and do not fully respond to therapy Full external and intracavitary irradiation is followed by simple extrafascial hysterectomy, which removes the resistant central disease
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Chemo-radiation Adjuvant chemotherapy Cisplatin initially used as an adjuvant to improve results with radiotherapy or shrink tumor size before surgery Radiotherapy is now combined with adjuvant Cisplatin chemotherapy in a chemo-radiation protocol
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Results of therapy