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Antiviral drugs PowerPoint Presentation

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Description : This medical presentation titled ""Antiviral drugs"" provides a classification of antiviral drugs, identifies major sites of antiviral drug action, presents chemical structures of some antiviral nucleoside and nucleotide analogs, and talks about anitretroviral agents.

Tags : Antiviral drugs, Human Immunodeficiency Virus, HIV, infection, cells, immune system, AIDS, Acquired Immune Deficiency Syndrome, HIV Positive, Anti-HIV Drug, antiretroviral drugs, AIDS drugs, Integrase Inhibitors, Entry Inhibitors, PHARMACOLOGY, DEOXYNUCLEOSIDES

Published on : Apr 23, 2021 | Views : 3653 | Downloads : 15

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Antiviral drugs By S.Bohlooli, PhD School of Medicine, Ardabil University of Medical Sciences
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The major sites of antiviral drug action.
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Chemical structures of some antiviral nucleoside and nucleotide analogs
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Chemical structures of some antiviral nucleoside and nucleotide analogs
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Chemical structures of some antiviral nucleoside and nucleotide analogs
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Agents to treat Herpes Simplex Virus (HSV) & Varicella Zoseter Virus (VZV) infections Acyclovir Valcyclovir Famciclovir Penciclovir Trifluridine
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Agents to treat Cytomegalovirus (CMV) infections Ganciclovir Valganciclovir Cidofovir Foscarnet Fomivirsen
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Anitretroviral agents: Nucloside Reverse Transcriptase Inhibitors (NRTIs) Zidovudine Didanosine Lamivudine Zalcitabine Stavudine Abacavir
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Anitretroviral agents: Nucleutide inhibitors Tenofovir
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Anitretroviral agents: NonNucleoside Reverse Transcriptase Inhibitors (NNRTIs) Nevirapine Delaviridine Efavirenz
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Anitretroviral agents: Protease Inhibitors Saquinavir Ritonavir Lopinavir Ritonavir Indinavir Nelfinavir Ampernavir
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Fusion Inhibitors Enfuvirtide (HIV) Docosanol (HSV)
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Anti-Hepatitis agents Lamivudine Adefovir Interferon alpha Pegylated interferon alpha Ribavirin
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Anti-Influenza Agents Amantadine Rimantadine Zanamivir Oseltamivir
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Other Antiviral agents Palivizumab Imiquimod
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Replicative cycles of herpes simplex virus, an example of a DNA virus, and the probable sites of action of antiviral agents.
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Replicative cycles of influenza, an example of an RNA virus, and the loci for effects of antiviral agents.
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Mechanism of action of antiherpes agents
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Replicative cycle of HIV-1, an example of a retrovirus, showing the sites of action of antiviral agents. Various antiviral agents are shown in blue. Key: RT, reverse transcriptase; cDNA, complementary DNA; mRNA, messenger RNA; Tat, a protein that regulates viral transcription and affects the rate of replication; RNaseH, ribonuclease H; gp120, envelope glycoprotein.
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Life cycle of HIV
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Entry Inhibitors Efuvirtide (T-20) 36-amino acid peptide binds to gp41 viral envelope glycoprotein Resistance can occur but there is no cross resistance Drug administration subcutaneously in combination with other antiretroviral drugs Side effects: Local injection site reaction, hypersensitivity reaction,Eosinophilia Maraviroc binds specifically and selectively to CCR5
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Integrase Inhibitors Raltegravir A pyrimidinone analog that binds integrase
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