Download Free Medical Adenoid Cystic Carcinoma AdCC - Cylindroma PowerPoint Presentation

Adenoid Cystic Carcinoma AdCC - Cylindroma PowerPoint Presentation

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Description : Check out this medical presentation on cancer titled "Adenoid Cystic Carcinoma(AdCC) - Cylindroma" to know about one of the more common salivary gland malignancies (MEC / PLGA / AdCC), originally called a cylindroma.

Tags : Cancer, Adenoid Cystic Carcinoma, AdCC, Cylindroma, salivary gland, malignancies, MEC, PLGA, histopathologic features, myoepithelial cells, ductal cells, maxillary sinus, submandibular gland

Published on : May 05, 2021 | Views : 1991 | Downloads : 3

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Adenoid Cystic Carcinoma(AdCC) cylindroma
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one of the more common salivary gland malignancies (MEC / PLGA / AdCC) Because of its distinctive histopathologic features, it was originally called a cylindroma A high grade malignancy
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Histopathologic Features composed of a mixture of myoepithelial cells and ductal cells that can have a varied arrangement Three major patterns: Cribriform Tubular solid Usually a combination of these is seen
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The cribriform pattern is the most classice characterized by islands of basaloid epithelial cells that contain multiple cylindric, cystlike spaces resembling Swiss cheese cystlike spaces often contain a mildly basophilic mucoid material, a hyalinized eosinophilic product, or a combined mucoid hyalinized appearance. homogeneous acidophilic material
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small and cuboidal, cells deeply basophilic nuclei little cytoplasm fairly uniform Rare mitotic activity Cribriform (Swiss cheese)
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Normal salivary glands Adjacent with tumor
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Cribriform pattern
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The tubular lumina can be lined by one to several layers of cells (ductal cells and myoepithelial cells) tubular pattern occur as multiple small ducts or tubules within a hyalinized stroma
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tubular pattern
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hyalinized "stroma
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solid variant consists of larger islands or sheets of tumor cells little tendency toward duct or cyst formation
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cellular pleomorphism and mitotic activity small and cuboidal, cells deeply basophilic nuclei little cytoplasm fairly uniform Solid Cribriform
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as well as focal necrosis in the center of the tumor islands, may be observed
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A highly characteristic but no pathognomonic perineural invasion which probably corresponds to the common clinical finding of pain in these patients a swirling arrangement around nerve bundles This marked tendency to proliferate around and along nerves for great distances accounts for the tumor's marked tendency to recur.
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Tumors with a solid histopathologic pattern are associated with a worse outlook the prognosis is poorest for tumors arising in the maxillary sinus and submandibular gland. The end