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Tourettes Syndrome and Tic Disorders PowerPoint Presentation

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This medical PowerPoint presentation talks about Tourettes Syndrome and Tic Disorders.
Tourettes Syndrome is a neurological disorder characterized by repetitive, involuntary movements and vocalizations called tics. These tics can range from simple movements like eye blinking or facial grimacing, to more complex movements like jumping or spinning, and vocal tics like throat clearing or repetitive vocalizations.
Tic disorders are a group of neurological disorders that involve involuntary movements or sounds, and include Tourettes Syndrome as well as other conditions like chronic motor tic disorder and chronic vocal tic disorder.

Tags : Tourettes Syndrome, Tic Disorders, neurological disorder, chronic motor tic disorder, chronic vocal tic disorder, Child Neurology PowerPoint presentation, Neurology PowerPoint presentation

Published on : Mar 21, 2023 | Views : 918 | Downloads : 0

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Slide 1-

Tourettes Syndrome and Tic Disorders Jess P. Shatkin, MD, MPH Vice Chair for Education NYU Child Study Center New York University School of Medicine
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Learning Objectives Residents will be able to: 1) Describe the two cardinal symptoms of Tourette’s Syndrome 2) Identify nine primary categories of rule-out diagnoses for Tourette’s and two primary comorbidities 3) Demonstrate an understanding of the natural history of the illness by matching the stages of Tourette’s with the correct age of the patient 4) Identify two psychosocial treatments and three pharmacological treatments for Tourette’s 5) Demonstrate comfort with rating scales for Tourette’s and Ti Disorders
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What is a tic? A “tic” is a sudden, rapid, recurrent, non-rhythmic, stereotyped motor movement or vocalization A tic may be simple (involving only a few muscles or simple sounds) or complex (involving multiple groups of muscles recruited in orchestrated bouts or words or sentences)
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Motor Tics (Simple) Generally lasting less than several hundred milliseconds Examples include: eye blinking nose wrinkling neck jerking shoulder shrugging facial grimacing abdominal tensing
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Motor Tics (Complex) Longer in duration than simple tics; usually lasting seconds or longer Examples include: hand gestures jumping, touching, pressing, or stomping facial contortions repeatedly smelling an object squatting and/or deep knee bends retracing steps and/or twirling when walking assuming and holding unusual positions (including “dystonic” tics, such as holding the neck in a particular tensed position)
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Copropraxia & Echopraxia Both are considered complex motor tics Copopraxia = a sudden, tic-like vulgar, sexual, or obscene gesture Echopraxia = a mirror phenomena, such as involuntary, spontaneous imitation of someone else’s movements
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Vocal Tics (Simple) Meaningless brief sounds Examples include: Throat clearing Grunting Sniffing Snorting Chirping
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Vocal Tics (Complex) More clearly involve speech and language Examples include: sudden, spontaneous expression of single words or phrases speech blocking sudden and meaningless changes in pitch, emphasis, or volume of speech;
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The “Lalias” All are considered complex vocal tics Palilalia = repeating one’s own sounds or words Echolalia = repeating the last heard sound, word, or phrase Coprolalia = the sudden, inappropriate expression of a socially unacceptable word or phrase that may include obscenities as well as specific ethnic, racial, or religious slurs (found in fewer than 10% of individuals with tic disorders)
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History of Tourettes The first case was reported by a French physician, Itard, in 1825. He described the case of the Marquise de Dampierre, a woman of nobility who was quite important in her time. The Marquise suffered motor tics, coprolalia, and echolalia from the age of 7. Itard wrote: “The more she herself thinks her vulgarities will be revolting, the more she is tortured by the fear that she will utter them, and it is precisely this preoccupation, that when she can no longer control it, puts these words at the tip of her tongue.”
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George Gilles de la Tourette In 1885 another French doctor, Tourette, described nine cases with the syndrome that now carries his name. One of his cases was the Marquise de Dampierre, who by then was in her nineties. Throughout much of the 20th century, Tourette’s was believed to have a psychogenic origin. More recent research, however, has resulted in a return to Tourette’s initial impression of the disorder as a nonprogressive, hereditary neurological condition.
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Onset of Tourette’s Typically, the disorder begins with a simple motor tic on the face (e.g., blinking). The tics persist and generalize to other parts of the body; waxing and waning is typical. Eventually, vocalizations (e.g., sniffing, snorting, throat clearing, barking, hiccuping, or uttering nonsense words or intelligible words) ensue and are typically “explosive.”
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Urges & Premonitions Tics are generally experienced as irresistible but can be suppressed for various lengths of time Some children are not aware of their tics but with age a premonitory urge (a rising tension or somatic sensation that is relieved when the tic occurs) may arise
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Premonitory Urge “I guess it’s sort of an aching feeling in a limb or a body area, or else in my throat if it proceeds a vocalization. If I don’t relieve it, it either drives me crazy or begins to hurt (or both) – in that way it’s both mental and physical.” “A need to tic is an intense feeling that unless I tic or twitch I feel as if I’m going to burst. Unless I can physically tic, all of my mental thoughts center on ticking until I am able to let it out. It’s a terrible urge that needs to be satisfied.” Leckman
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Frequency & Duration of Tics Individuals may feel the need to perform the tic repeatedly or in a specific way until it has been done “just right” Tics are often emitted in bouts of one or several tics, separated by periods without tics lasting seconds to hours Tics generally disappear during sleep and during intense sexual arousal Tics generally change in severity over the course of a day and may change in location over time Tics may vary in their frequency and disruptivity depending upon the circumstance (e.g., school, home, work, etc.)
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When Do Tics Occur? Tics are often more frequent when an individual relaxes in private (e.g., watching TV) and less frequent when an individual engages in directed, effortful activity (e.g., reading) Tics may be exacerbated during periods of stress
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Other Symptoms of Tourette’s Other abnormal movements and behavior patterns can also develop: Stuttering Sticking out the tongue Smelling objects Pounding the chest or body Grabbing at one’s genitals Compulsive touching Bruxism Echopraxia
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DSM-IV Diagnostic Criteria Both multiple motor and one or more vocal tics have been present at some time during the illness, although not necessarily concurrently. (A tic is a sudden, rapid, recurrent, nonrhythmic, stereotyped motor movement or vocalization.) The tics occur many times a day (usually in bouts) nearly every day or intermittently throughout a period of more than 1 year, and during this period there was never a tic-free period of more than 3 consecutive months. The onset is before age 18 years. The disturbance is not due to the direct physiological effects of a substance (e.g., stimulants) or a general medical condition (e.g., Huntington’s disease or postviral encephalitis).
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Differential Diagnosis of Tourettes Transient tics of childhood Prenatal/perinatal insults Congenital CNS defects Birth defects Infections/post-infectious Post-viral encephalitis HIV infections of CNS Lyme disease PANDAS
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Differential Diagnosis of Tourettes (2) Head trauma Toxin exposure Carbon monoxide or gasoline Drugs Neuroleptics, levodopa, opiate withdrawal, amphetamines, lamotrigine Chromosomal abnormalities XYY XXY Fragile X syndrome
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Differential Diagnosis of Tourettes (3) Genetic disorders Hallervorden-Spatz Disease Wilson’s Disease Hyperekplexias Rett Syndrome Neuroacanthocytosis Autism/Asperger’s syndrome
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Natural History of Tic Disorders 20-25% of people will develop a transient tic at some point in their lives With Tourettes after onset there is typically: Prepubertal exacerbation Postpubertal attenuation Adult stabilization Once thought to be a lifelong disorder, retro-spective cohort studies have now demonstrated 50% of TS patients to be asymptomatic by age 18 The adulthood course of TS is generally stable with up to 65% of patients not exhibiting any changes in symptomatology over 5 years.
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Epidemiology of Tourettes Found in all racial and ethnic groups Exact prevalence is unknown b/c of misdiagnosis, underreporting, and few large epidemiological studies In one large screening study of over 28,000 Israeli army recruits (16-17 y/o), an overall rate of 4.3/10,000 (4.9 in M; 3.1 in F) In a study of 4500 children aged 9, 11, & 13 in the southeastern U.S. found a total prevalence of 10/10,000 DSM-IV reports a prevalence of 3-5/10,000 in children and 1-2/10,000 in adults
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Structural Neuroimaging Findings General neuroimaging and neuropathological examination of TS brains is normal However, morphological abnormalities have been reported in volumetric MRI studies: A loss or reversal of normal asymmetries of the putamen and lenticular nucleus has been noted Corpus callosum morphology (and therefore interhemispheric connectivity) appears to be altered in (at least) males with TS
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Functional Neuroimaging Findings SPET studies have detected hypoperfusion in various brain structures bilaterally (including the BG, orbitofrontal cortex, and temporal lobes) PET scans have shown decreased activity in prefrontal cortices and striatum fMRI studies have suggested: Increased utilization of the supplemental motor cortex Significant b/l decrease in GP and putamen activity Abnormal signals with tic occurrence in the primary motor and Broca’s areas, corresponding to motor and vocal tics; and striatal activity
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Genetics of Tourettes Numerous family studies have demonstrated that TS is inherited and that 1st degree relatives of a proband are at increased risk Increased rates of chronic & transient tics are also found among 1st degree relatives, suggesting alternate expressions of TS Twin studies demonstrate 8% concordance in dizygotics and 53% in monozygotes; if all tic disorders are taken into account, dizygotes are 22% concordant and monozygotes are 77% Incomplete penetration/concordance suggests other factors are at play (e.g., genomic imprinting)
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Comorbidities: ADHD The rate of co-occurrence of ADHD and TS has been reported as being between 8 – 80% Regardless of the precise frequency, it is apparent that ADHD and TS do frequently occur together in those patients who seek medical attention ADHD also occurs at an increased rate in the probands of patients with TS These facts suggest a shared group of genes
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Comorbidities: OCD Obsessive compulsive symptoms and OCD are strongly associated with TS Approximately 8% of patients with OCD have TS Approximately 35% of patients with TS have OCD A number of studies have demonstrated a difference in the nature of obsessions and compulsions in TS patients vs. pure OCD patients TS patients tend to have obsessions centered on symmetry and getting things “just right;” in addition, they tend to have more violent and sexual obsessions, are more often male, have an earlier age of onset, and may be less responsive to treatment with SSRIs Also more touching, counting, blinking and staring obsessions Patients with pure OCD report more contamination obsessions and washing behaviors
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Comorbidities: Other A variety of other behaviors and abnormalities have been reported to be present in a higher than expected frequency among TS patients: Anxiety disorders (esp, phobias) Depression Oppositional Defiant Disorder Restless Leg Syndrome Stuttering
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Comorbidities: Psychosocial Children with TS often have difficulties at school, such as grade retention or special education placement Up to 1/3 may be diagnosed with an LD, which seems to be more related to comorbid ADHD than the tic symptoms of TS Children with TS have increased difficulties with peer relationships and social functioning
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PANDAS Pediatric Autoimmune Neuropsychiatric Disorders Associated with Strep A possible cause of OCD and Tourettes Group A β-hemolytic streptococcal infection in select individuals may induce neuronal damage Rat striata infused with sera from patients with TS with a high level of strep antibodies demonstrated an increase in total and daily oral stereotypies vs. rats with sera from normal controls and TS patients with low levels of antibodies
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Treatments: Psychosocial Education Patient, family, and school Counseling for family and patient Relaxation therapy Supportive therapy Habit Reversal Therapy
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HRT 4 Components: Awareness training --learn to recognize when they’re ticking Development of a competing response --less noticeable, can be carried out for more than a few minutes Building motivation --make a list of the problems caused by tics, all the bad things it brings Generalization of new skills --practice the skills in new contexts and locations
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Treatments: Pharmacological Mild illness is unlikely to require medication α-2 agonists Tenex Clonidine Neuroleptics Other dopaminergic agents Metaclopramide (D-2 antagonist without antipsychotic properties) Pergolide (dopamine agonist) Others Flunarizine Naloxone Opiates THC Baclofen Nicotine Desipramine SSRIs
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Antipsychotic Treatment Historically high potency first generation antipsychotics Pimozide (Orap) best studied Haloperidol Severe side effects has led to search for alternative 2nd generation antipsychotics
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Yale Global Tic Severity Scale A simple tracking device for assessing the nature and severity of tics Addresses the following categories: Simple motor Complex motor Simple phonic Complex phonic Behavior Uses a Likert Scale Most tic exacerbations will be identified with the change on the YGTSS is greater than “9” and the total current YGTSS score exceeds “19”
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Aripiprazole A 12-week, open-label trial, flexible dosing of aripiprazole performed with 15 youth, aged 7-19 years. YGTSS at baseline, weeks 3, 5, 9, and end point scores were compared. Significant decreases in the scores of motor and phonic tics, global impairment, and global severity were demonstrated between baseline and week 3, and the scores continued to improve thereafter. (Seo et al, 2008) Open-label, flexible-dose 6-week study of 16 youth (15 males) aged 8-17 years; weekly ratings for OCD, tics, ADHD and Sefx; ave dose was 3.3 mg/d. Significant pre-and post-treatment differences were ascertained for the YGTSS for motor, phonic, and total tics. Significant improvements in co-morbid disorders as well, including OCD, ADHD, and depressive disorders. (Murphy et al, 2009) 11 subjects (10 male), 9-19 years, who did not respond or couldn’t tolerate prior meds, treated with flexible dose for 10 weeks; mean dose 4.5 mg/d YGTSS and CGI-tic severity scores showed significant improvement in 10 of 11 subjects (Lyon et al, 2009)
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Treatments: Comorbid Conditions OCD SSRIs +/- antipsychotics ADHD History of concern that stimulants would “unmask” tics Multicenter, RDBPC study of MTP and clonidine (alone and in combination) in 136 children with Tourettes demonstrated: Significant improvement in ADHD with both treatments Greatest benefit resulting from a combination of both The proportion of subjects reporting a worsening of tics was no higher amongst those treated with MTP alone (20%) vs. clonidine (26%) vs. placebo (22%)
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Clonidine Patch 437 patients, who met Chinese Classification of Mental Disorders-third edition diagnostic criteria for transient tic disorder (5%), chronic motor or vocal tic disorder (40%) or Tourette’s disorder (55%), aged 6-18 years Participants in the active treatment group were treated with a clonidine adhesive patch and participants in the clinical control group with a placebo adhesive patch for 4 weeks. The dosage of the clonidine adhesive patch was 0.1mg, 0.15mg or 0.2mg per day, depending on each participant's bodyweight. After 4 weeks of treatment the active treatment group participants' YGTSS score was significantly lower than that of the clinical control group (p=0.03). Further, the active treatment group had a significantly better therapeutic response than the clinical control group (p=0.003). The response rate in the active treatment group was 68.85% compared to 46.85% in the clinical control group (p=0.0001). Du et al, 2008
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Risperidone vs. Clonidine 7 to 14-day single-blind, placebo lead-in, 21 subjects (7-17 years) randomly assigned to 8 weeks of double-blind treatment with clonidine or risperidone. Followed tics, OCD, and ADHD symptoms. Risperidone and clonidine appeared equally effective in the treatment of tics as rated by YGTSS. Risperidone produced a mean reduction in the YGTSS of 21%; clonidine produced a 26% reduction. Among subjects with comorbid obsessive-compulsive symptoms, 63% of the risperidone group and 33% of the clonidine group responded to treatment (not significant). Gaffney et al, 2002