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Some Bodies in the Brain PowerPoint Presentation

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Description : Check out this medical presentation on Carney Complex, which is titled "Some Bodies in the Brain", to know about “bodies” that populate neuropathology.

Tags : Carney Complex, Some Bodies, Brain, neuropathology, Psammoma bodies, Verocay body, Eosinophilic Granular Bodies (EGB), Negri bodies, Cortical Lewy Body, Bunina bodies, Corpora amylacea, Lafora body, polyglucosan body, Hirano body

Published on : May 13, 2021 | Views : 1962 | Downloads : 0

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Slide 1-

“SOME BODIES IN THE BRAIN” Ronald L. Hamilton, M.D. Associate Professor of Neuropathology, University of Pittsburgh
Slide 2-

Some Bodies in the Brain Identify these “bodies” that populate neuropathology
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Psammoma bodies
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Verocay body
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Eosinophilic Granular Bodies (EGB)
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Negri bodies
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Cortical Lewy Body
Slide 8-

Round basophilic inclusion #1 (Pick body vs. mnd inclusion body)
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Round basophilic inclusion #2 (Pick body vs. mnd inclusion body)
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Bunina bodies
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Corpora amylacea
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PAS stain Lafora body (polyglucosan body)
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Hirano body
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Granulovacuolar degeneration (Simchowicz bodies)
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Marinesco body
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Herring bodies
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Buscaino bodies (mucocytes)
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Zebra bodies
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Fingerprint bodies
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Psammoma bodies Psammoma bodies: meningioma
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Psammoma bodies Derived from meningothelial whorls Psammomatous meningioma spinal cord (females)
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Psammoma bodies melanotic Schwannomas - 50% are psammomatous half of melanotic psammomatous Schwannomas have Carney complex Auto dominant mutation in Protein kinase A holoenzyme lentiginous facial pigmentation cardiac myxoma, calcifying Sertoli cell tumors endocrine overactivity Cushing syndrome multinodular adrenal hyperplasia acromegaly - pituitary adenoma
Slide 25-

Verocay bodies Schwannoma Antoni A areas Infrequent in acuostic and cellular Schwannomas
Slide 26-

Verocay bodies Bilateral acoustic schwannomas = NF II autosomal dominant 22q12 - merlin (schwannomin) similar to cytoskeletal proteins moesin, ezrin, radixin (MER) +meningiomas, spinal ependymomas, posterior lens opacities, meningioangiomatosis
Slide 27-

Eosinophilic Granular Bodies (EGB) Gangliogliomas, Pilocytic Astrocytomas, Pleomorphic Xanthoastrocytoma Degenerating tumor astrocytes PAS-positive
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Eosinophilic Granular Bodies (EGB)
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Eosinophilic Granular Bodies (EGB) I
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Negri bodies Rabies encephalitis Purkinje cells, CA-1 hippocampus >10,000 human deaths per year
Slide 31-

Negri bodies
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Lewy bodies Parkinson’s Disease DLB, LBVAD, MSA, age
Slide 33-

Lewy bodies May be multiple
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Lewy bodies Cortical Lewy bodies Entorhinal cortex, cingulate gyrus, insular cortex, other neocortex
Slide 35-

Lewy bodies Cortical LB can be difficult to detect on H&E Strongly ubiquitin-positive (vs. globose NFT)
Slide 36-

Lewy bodies Alpha-synuclein positive, specific and sensitive
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Lewy bodies Hyaline bodies are abnormal aggregates of AS May be precursor to LB
Slide 38-

Pick bodies Pick’s disease Fronto-temporal dementia Severe neuronal loss and gliosis (“knife-edge” atrophy) Neocortex, dentate gyrus
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Pick bodies Strongly argyrophilic (silver stains - Bielschowsky, Bodian) ++tau, +ubiquitin +/- Pick cells (balloon cells) EM-straight filaments Pick cell Tau
Slide 40-

MND-inclusion bodies Motor Neuron Disease (MND) inclusion body ALS, ALS with dementia or aphasia FTD (mnd-inclusion body dementia), Primary progressive aphasia Superficial neocortex, dentate gyrus NOT IN MOTOR NEURONS
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MND-inclusion bodies Negative silver stain Ubiquitin positive Negative for tau and alpha-synucelin Composition unknown ubiquitin ubiquitin
Slide 42-

Pick bodies vs. mnd-inclusion bodies I Pick MND-inclusion Tau ubiquitin Bielschowsky
Slide 43-

Bunina bodies Lower motor neurons ALS Unknown composition
Slide 44-

ALS - other LMN inclusions Hyaline bodies Ubiquitin skeins
Slide 45-

Corpora amylacea Subpial and perivascular most common location
Slide 46-

Corpora amylacea Increased with age, Neurodegeneration. Olfactory bulb, base of brain, spinal cord Astrocytic inclusion
Slide 47-

Corpora amylacea PAS-positive and ubiquitin-positive Ubiq PAS
Slide 48-

Lafora Bodies Lofora Body Disease Polyglucosan Body Disease Myoclonic epilepsy Autosomal recessive Intraneuronal inclusions Liver biopsy
Slide 49-

Hirano bodies Hippocampus CA-1, subiculum Neuronal cytoplasmic inclusion Actin and actin-related proteins Non-specific Increased with age esp. with AD
Slide 50-

Hirano bodies
Slide 51-

Hirano Body (x165,000)
Slide 52-

Granulovacuolar bodies of Simchowicz Non-specific, increased in aged and esp. AD Hippocampus CA-1, subiculum, more rarely other
Slide 53-

Granulovacuolar bodies of Simchowicz Often multiple Tau-positive Unknown composition
Slide 54-

Marinesco bodies Non-specific Substantia Nigra, LC Aged, Parkinson’s PAS-neg, pink on Masson’s trichrome
Slide 55-

Herring Bodies Posterior pituitary, swollen axons, incidental
Slide 56-

Herring bodies I
Slide 57-

Buscaino Bodies Artifact of formalin fixation ?<10%, ?not buffered Do not mistake for edema or storage disorder
Slide 58-

Buscaino Bodies “mucocytes” PAS-positive
Slide 59-

Zebra bodies Lysosomal storage disorder Mucopolysaccharidoses (MPS I, II and III) Hunter-Hurler, Sanfillipo Cranial nerve nuceli, liver, skin PAS-positive, LFB-positive Water soluble Rare in metachromatic leukodystrophy
Slide 60-

Fingerprint bodies Neuronal ceroid lipofuscinosis (NCL, types 1-7) Batten’s Disease, et al. Autosomal recessive PAS-positive LFB, Sudan Black, Oil-red O Lipid stains remain in paraffin Autofluorescent EM - Skin biopsy, lymphocytes (buffy coat prep)
Slide 61-

Fingerprint bodies EM 60,000-80,000
Slide 62-

NCL Curvilinear bodies Skin biopsy Lymphocytes (buffy coat prep)
Slide 63-

Fingerprint bodies Infantile NCL - granular osmiphilic deposits (GRODs) Late-infantile NCL - curvilinear bodies Juvenile NCL - FINGERPRINT BODIES Onset age 4-9 years old pigmentary retinopathy seizures, dementia, blindness spastic paraplegia death age 20-30
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