Download Free Medical Regulation of Blood Pressure PowerPoint Presentation

Regulation of Blood Pressure PowerPoint Presentation

DOWNLOAD MEDICAL POWERPOINT PRESENTATION

About This Presentation

Description : Check out this medical presentation on Blood Pressure, which is titled "Regulation of Blood Pressure", to know about the factors regulating arterial blood pressure, know how they influence arterial blood pressure, know the physiological importance of regulating arterial blood pressure, and know the short term, intermediate and long-term regulation of blood pressure; nervous, hormonal and renal regulation of arterial blood pressure.

Tags : Blood Pressure, Regulation, arterial blood pressure, nervous, hormonal, renal

Published on : Jun 02, 2021 | Views : 5114 | Downloads : 11

Shareable Url :

Embed Code :

Comment

Transcript

Slide 1-

REGULATION OF BLOOD PRESSURE Prof. Sultan Ayoub Meo MBBS, Ph.D (Pak), M Med Ed (Dundee), FRCP (London), FRCP (Dublin), FRCP (Glasgow), FRCP (Edinburgh) Professor and Consultant, Department of Physiology, College of Medicine, King Saud University, Riyadh, KSA
Slide 2-

Factors regulating arterial blood pressure Explain how they influence arterial blood pressure. Physiological importance of regulating arterial blood pressure Discuss short term, intermediate and long-term regulation of blood pressure; nervous, hormonal and renal regulation of arterial blood pressure. LECTURE OBJECTIVES
Slide 3-

REGULATION OF BLOOD PRESSURE
Slide 4-

REGULATION OF BLOOD PRESSURE
Slide 5-

SHORT TERM REGULATION OF BLOOD PRESSURE Baroreceptors Reflex Mechanism Chemoreceptors Mechanism CNS Ischemic Response Mechanism Atrial Stretch Volume Receptors Rapidly acting within seconds to minutes
Slide 6-

1. THE BARORECEPTORS Changes in MAP are detected by baroreceptors (pressure receptors) in the carotid and aortic arteries. Carotid baroreceptors are located in the carotid sinus, both sides of the neck. Aortic baroreceptors are located in the aortic arch. These receptors provide information to the cardiovascular centres in the medulla oblongata about the degree of stretch with pressure changes.
Slide 7-

Guyton and Hall, pp 174 1. THE BARORECEPTORS
Slide 8-

At normal arterial pressure the baroreceptors are active. Increased blood pressure increases their rate of activity, while decreased pressure decreases the rate of firing (activity). They play an important role in maintaining relatively constant blood flow to vital organs such as brain during rapid changes in pressure such as standing up after lying down. That is why they are called “pressure buffers”. 1. THE BARORECEPTORS
Slide 9-

1. THE BARORECEPTORS
Slide 10-

↑ MAP Baroreceptors ↑ Parasympathetic (vagal) activity ↓ Sympathetic activity ↓ HR ↓ SV ↓ TPR 1. THE BARORECEPTORS
Slide 11-

1. THE BARORECEPTORS
Slide 12-

1. THE BARORECEPTORS
Slide 13-

Baroreceptors are important in maintaining MAP constant during changes in body posture. When change of posture from supine to erect, drop in the MAP in the head and upper part of the body. The barorecptor reflex is activated → strong sympathetic impulses → vasoconstriction. This minimizes the drop in MAP. 1. THE BARORECEPTORS
Slide 14-

ARTERIAL BARORECEPTOR REFLEX ROLE IN HEMORRAHAGE
Slide 15-

2. THE CHEMORECEPTOR REFLEX Chemoreceptors have high blood flow (1200 ml/min/g tissue). This makes it easy for these cells to detect changes in O2, CO2, and H+. Reduced blood flow (due to reduced MAP) stimulates the chemoreceptors through oxygen lack, increased hydrogen ions or carbon dioxide. Chemoreceptors are stimulated when the MAP is lower than 60 mmHg. Response is excitatory, NOT inhibitory; mainly through activation of sympathetic nervous system. They reduce blood flow to unessential areas and protect vital tissues like brain and heart.
Slide 16-

3. CNS ISCHEMIC RESPONSE CNS ischemic response operates rapidly to prevent further decrease in MAP whenever blood flow to the brain decreases. It is one of the most powerful activators of the sympathetic vasoconstrictor system. When MAP < 20 mmHg → cerebral ischemia of vasomotor center → strong excitation of vasomotor center (due to accumulation of CO2, lactic acid,) → strong vasoconstriction of blood vessels including the kidney arterioles.
Slide 17-

4. ATRIAL STRETCH VOLUME RECEPTORS Receptors in large veins close to heart, walls of the atria (response of blood volume). An increased blood volume  stretch of atria  activate atrial volume receptors  sensory afferent nerves to medulla inhibiting the cardiovascular centre  This results into decreased blood volume through: (a)   sympathetic drive to kidney:  dilate afferent arterioles   glomerular capillary hydrostatic pressure  GFR   blood volume (towards normal).  renin secretion (Renin is an enzyme which activates angiotensinogen in blood). Inhibition of renin secretion  inhibit RAAS  inhibit aldosterone production   Blood volume (towards normal) (b)   ADH secretion   blood volume (towards normal). (c)   Atrial Natriuretic Peptide (ANP) causes loss of blood volume.
Slide 18-

INTERMEDIATE TERM REGULATION OF BLOOD PRESSURE Renin – Angiotensin system Capillary shift mechanism Stretch relaxation of vessels Respond from 30 min to several hrs
Slide 19-

Renin – Angiotensin system INTERMEDIATE TERM REGULATION OF BLOOD PRESSURE
Slide 20-

Renin – Angiotensin system INTERMEDIATE TERM REGULATION OF BLOOD PRESSURE
Slide 21-

INTERMEDIATE TERM REGULATION OF BLOOD PRESSURE Renin – Angiotensin system
Slide 22-

INTERMEDIATE TERM REGULATION OF BLOOD PRESSURE 2. Capillary shift mechanism Movement of fluid from interstitial spaces into capillaries in response to ↓ BP to maintain blood volume. Conversely, when capillary pressure ↑ too high, fluid is lost out of circulation into the tissues, reducing blood volume as well as all pressures throughout circulation
Slide 23-

INTERMEDIATE TERM REGULATION OF BLOOD PRESSURE 2. Capillary shift mechanism
Slide 24-

INTERMEDIATE TERM REGULATION OF BLOOD PRESSURE 3 Stretch Relaxation of Vessels Blood vessel smooth muscle respond to changes in blood volume. When pressure in blood vessels is “too high”, vessels stretched and stretching more and more for minutes or hours; resulting in decrease blood pressure in vessels toward normal. The continuing stretch response of the vessels can serve as an intermediate-term pressure “buffer.”
Slide 25-

LONG TERM REGULATION OF BLOOD PRESSURE (acting within days to months) Renal Body fluid control mechanism Aldosterone Mechanism
Slide 26-

LONG TERM REGULATION OF BLOOD PRESSURE Renal Body fluid control mechanism
Slide 27-

LONG TERM REGULATION OF BLOOD PRESSURE Renal Body fluid control mechanism
Slide 28-

LONG TERM REGULATION OF BLOOD PRESSURE Renal Body fluid control mechanism
Slide 29-

LONG TERM REGULATION OF BLOOD PRESSURE 2. Aldosterone Mechanism
Slide 30-

LONG TERM REGULATION OF BLOOD PRESSURE 2. Aldosterone Mechanism
Slide 31-

THANK YOU