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Radiotherapy Research in Gynaecological Cancers PowerPoint Presentation

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Description : Check out this medical PowerPoint presentation titled "Radiotherapy research in gynaecological cancers” by Dr Susan Lalondrelle.

This medical PowerPoint presentation is about radiotherapy which plays an important role in the treatment of gynecological cancers, which include cervical, endometrial, ovarian, vaginal, and vulvar cancers. Over the years, there has been a significant amount of research dedicated to improving radiotherapy outcomes in gynecological cancers

Tags : Radiotherapy research, gynaecological cancers, treatment of gynecological cancers, cervical cancer, endometrial cancer, ovarian cancer, vaginal cancer, vulvar cancers, Gynecologic Oncology, Gynecologic Oncology PowerPoint presentation

Published on : May 29, 2023 | Views : 1616 | Downloads : 0

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Radiotherapy research in Radiotherapy research in gynaecological cancersDr Susan Lalondrelle
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Large fields to avoid miss = increased toxicity
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Poor image quality = large fields= increased toxicity
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Visualisation: Ultrasound Combined Ultrasound and Cone Beam CT Improves Target Segmentation for Image Guided Radiation Therapy in Uterine Cervix Cancer. Mason SA, White IM, O'Shea T, McNair HA, Alexander S, Kalaitzaki E, Bamber JC, Harris EJ, Lalondrelle S. Int J Radiat Oncol Biol Phys. 2019
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2. Reduced field size: Plan of the day Implementation and validation of Radiographer-led IGRT for cervix cancer S. E. Alexander, S Lalondrelle, H McNair
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Plan of the day - cervix LP1 LP2 LP3 LP4
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3. Better visualisation and reduced field size: MRlinac Visualisation Easier to see and define target (and tumour) and non-target tissues 2. Online replanning daily plan adaptation for target and non-target motion (and regression) 3. Intrafraction motion monitoring Improved accuracy may increase local control & reduce toxicity Guides dose escalation which may further increase local control
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Gynaecological cancer oligometastatic recurrence PRIMER and PERMIT studies RTPCT Phase 1 plan on CT week 0 RTPCT Phase 2 plan on CT acquired week 3 MRL Phase 2 plan on MRL acquire #1 Phase 2
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Real time response to daily variation : MRlinac
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4. Predicting and stratifying response Circulating HPVDNA NGS assay for detection of cHPV DNA in locally advanced cervix cancer treated with radiotherapy Blood samples at baseline, end of EBRT and 3 months correlated with imaging Pilot completed Tool for escalating dose or adding/ removing treatment RT Gene2 The aim of this research is to understand how certain genes in the body are affected by a range of doses and exposures to radiation. Multi-panel coding and non-coding transcriptional responses as an indicator of individualised responses to radiation effects in radiation therapy patients
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Summary – gynaecological radiotherapy Trials to implement new technologies such as ultrasound, MRlinac, stereotactic radiotherapy are delivering Improved visualisation and accuracy Online adaptive planning Enhanced monitoring of radiotherapy delivery Novel assays are being evaluated to predict Response to treatment to individualise dose Likelihood of toxicity
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Susan.lalondrelle@rmh.nhs.uk