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Peripheral Nerve Disorders PowerPoint Presentation

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Description : Check out this medical PowerPoint presentation titled "Peripheral nerve disorders: A practical overview" by Praveen Dayalu, MD.

This medical PowerPoint presentation is about peripheral nerve disorders which refer to any condition that affects the nerves outside of the brain and spinal cord. These nerves are responsible for carrying signals from the brain to the muscles and organs, and back again. Damage or injury to these nerves can result in a variety of symptoms, including numbness, tingling, weakness, and pain.

Some common peripheral nerve disorders include:

Peripheral neuropathy: This is a condition that results in damage to the peripheral nerves, leading to symptoms such as numbness, tingling, and weakness in the hands and feet. It can be caused by a variety of factors, including diabetes, alcoholism, and chemotherapy.
Carpal tunnel syndrome: This is a condition that occurs when the median nerve in the wrist becomes compressed, resulting in pain, numbness, and tingling in the hand and fingers.
Guillain-Barré syndrome: This is a rare condition that occurs when the immune system attacks the peripheral nerves, leading to weakness, numbness, and tingling in the arms and legs.
Radiculopathy: This is a condition that occurs when a nerve root in the spine becomes compressed or inflamed, leading to pain, weakness, and numbness in the corresponding area of the body.

Treatment for peripheral nerve disorders depends on the underlying cause of the condition. In some cases, the condition may be treated with medication, physical therapy, or surgery. In other cases, lifestyle changes may be necessary to manage symptoms and prevent further damage to the nerves.

Tags : Peripheral nerve disorders, Peripheral neuropathy, Carpal tunnel syndrome, Guillain-Barré syndrome, Radiculopathy, Orthopaedic Surgery, Orthopaedic Surgery PowerPoint presentation

Published on : Jun 23, 2023 | Views : 2942 | Downloads : 7

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Slide 1-

Peripheral nerve disorders: A practical overview Praveen Dayalu, MD Clinical Associate Professor Department of Neurology University of Michigan
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What is the Peripheral Nervous System? CNS is confined to brain and spinal cord PNS includes (in anatomical order) Anterior horn cell (located within spinal cord) Spinal nerve roots (radicles) Plexi (brachial and lumbosacral) Named peripheral nerves (e.g. median, peroneal) Tiny nerve endings (sensory fibers and tiny branches of lower motor axons at the neuromuscular junction) Neuromuscular junction and muscle 2
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Neuromuscular junction and muscle Ulnar nerve Brachial plexus C8 spinal nerve root Anterior horn cells (LMN) The PNS (Emphasizing Motor Structures)
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4 Myelin (Schwann cells) Many peripheral axons are myelinated
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Symptoms of PNS Disease Single focal lesions: weakness/numbness/ pain in one limb, often defined to one part of the limb Multiple or diffuse lesions: weakness/ numbness/pain in more than one limb, usually bilateral and distal 5
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Signs of PNS Disease Lower motor neuron signs (atrophy, fasciculations) Hyporeflexia or areflexia Patch of sensory loss, or stocking-glove sensory loss Not UMN signs (spasticity, hyperreflexia, upgoing toe) or “brain” signs (impaired consciousness, cognition, or language) 6
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Reflexes… repeated Hyperreflexia and spasticity occur with upper motor neuron lesions (CNS) Hyporeflexia, fasciculations, atrophy with lower motor neuron lesions (PNS) 7
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Workup Serologies, especially for treatable causes EMG helps localize and characterize lesions of PNS Imaging for some focal lesions, or to exclude CNS mimics (such as cord lesion or stroke) CSF analysis in demyelinating neuropathies, or polyradiculopathy Nerve biopsy 8
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Anterior Horn Cell 9
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Amyotrophic lateral sclerosis Anterior horn cells (lower motor neurons) and upper motor neurons degenerate Mix of UMN and LMN signs/symptoms Weakness, spasticity, multifocal muscle atrophy No sensory loss from ALS! Loss of speech, swallow, respiration Death in 2-5 years 10
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Neuromuscular junction and muscle Ulnar nerve Brachial plexus C8 spinal nerve root Radiculopathy
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Spinal Nerve Root Disorders Most common: monoradiculopathy (cervical or lumbosacral) Radiating pain, +/- weakness, +/- sensory loss. Reduced reflex for that root level Commonest causes: disk herniation, minor trauma, degenerative change Usually self-limited Image if severe, worsening, or concern for cancer, infection 12
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Neuromuscular junction and muscle Ulnar nerve Brachial plexus C8 spinal nerve root Plexopathy
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Plexopathy PNS syndrome in one limb not explained by a single spinal root, or by a single “named” peripheral nerve Causes: trauma or stretch, compression by tumor or hematoma, radiation, diabetic EMG confirms plexopathy Image if compressive lesion suspected 15
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Brachial Plexus behind clavicle, in upper thorax 16
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Lumbosacral Plexus: Pelvic, Retroperitoneal 17
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Neuromuscular junction and muscle Ulnar nerve Brachial plexus C8 spinal nerve root Mononeuropathy
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Mononeuropathy Weakness, numbness, pain, paresthesias confined to the distribution of UE: median nerve, radial n., ulnar n. LE: femoral n., sciatic n., peroneal n. Most common causes: entrapment, trauma, prolonged limb immobility (e.g., surgery) 19
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Important Mononeuropathies Median mononeuropathy at the wrist (carpal tunnel syndrome) Ulnar mononeuropathy at the elbow (cubital tunnel syndrome) Radial mononeuropathy (“Saturday night palsy”) wrist and finger drop Peroneal mononeuropathy (e.g., from leg crossing) one cause of footdrop 20
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Median n. Ulnar n. Peroneal n. Named peripheral nerves have well-defined sensory territories (and muscle targets) 21
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Peripheral Polyneuropathy
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“Peripheral Neuropathy” Distal symmetric polyneuropathy Affects longest sensory/ motor/ autonomic nerves Nerves are “dying back” Length dependent (“stocking glove”) Symmetric loss of pin/ temp / vibration/ proprioception; distal reflex loss Usually chronic. Many possible causes! 24
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Peripheral polyneuropathy symptoms Initially, feet numb with paresthesia/ pain Symptoms ascend:  legs fingertips Distal weakness (feet, or fingers/grip), atrophy, Severe sensory loss can cause “steppage gait”, “sensory ataxia”, imbalance, falls Feet prone to injuries, ulcers, deformation (e.g., “Charcot foot”) Autonomic: orthostasis, bladder and erectile dysfunction 25
Slide 26-

Causes of peripheral polyneuropathy Usually toxic or metabolic #1 cause: diabetes & impaired glucose tolerance B12 Hematologic (e.g., multiple myeloma) or other immunoglobulin disorders (check SPEP) Drugs: Li, chemotherapy Alcoholic neuropathy Liver or kidney disease HIV and neurosyphilis Inflammatory causes: connective tissue disease 26
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Workup for peripheral neuropathy? For typical distal symmetric sensory > motor neuropathy: glucose / a1c, B12, SPEP with ifix Need EMG and more if rapid or severe, prominent weakness, asymmetry, young patient
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AIDP = Acute Inflammatory Demyelinating Polyneuropathy Develops over ~2 weeks Follows viral infection or vaccination Weakness/ numbness/ paresthesia start in legs and ascend; reflexes lost early Intubate if severe weakness Autonomic instability, arrhythmia Rx: plasma exchange & IVIG Most have good long-term recovery 28
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Myopathy = muscle disease “Can’t raise arms up” “Tough to comb my hair” “Hard to get out of a chair” “Can’t climb stairs” 29
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Clues to a Myopathy Usually cause symmetric proximal limb weakness (upper/lower) Other possible sx: muscle pain, tenderness, atrophy; fatigue; change in urine color Extensive list of causes: TSH, CK, and med review are a good place to start 30
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Time for review questions?
Slide 32-

Over 3 days, a 42 y.o. RN rapidly weakens in all four limbs. She says “I think I have Guillain-Barré!” Which is the most urgent first step? EMG Spinal cord imaging Lumbar puncture Brain imaging 32
Slide 33-

A 61 y/o woman wakes up with a weak right arm. Zero strength in finger extensors, wrist extensors, and trace elbow extension. Flexion muscles are 5/5. Which is the most likely diagnosis? Left frontal stroke affecting motor cortex Carpal tunnel syndrome Right radial mononeuropathy Peripheral polyneuropathy 33
Slide 34-

Decreased reflexes are seen in all of the following except: AIDP Peripheral polyneuropathy Carcinomatous polyradiculopathy Alcoholic neuropathy Steroid myopathy 34
Slide 35-

Weakness and sensory loss in the left hand can be caused by all of the following except: Right hemisphere stroke Lung cancer invading brachial plexus Median mononeuropathy Amyotrophic lateral sclerosis Cervical herniated disk
Slide 36-

Which is the commonest symptom of radiculopathy in the general public? Weakness Radiating pain down a limb A patch of distinct sensory loss Bladder incontinence 36