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MIGRATION PowerPoint Presentation

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Description : Check out this medical presentation on Genetics, which is titled "MIGRATION", to learn about migration, movement of individuals from one subpopulation to another followed by random mating and its effects.

Tags : Genetics, migration, movement, subpopulation

Published on : Aug 29, 2021 | Views : 2352 | Downloads : 0

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Slide 1-

MIGRATION Movement of individuals from one subpopulation to another followed by random mating. Movement of gametes from one subpopulation to another followed by fertilization. Results in movement of alleles between populations (GENE FLOW). Can be a very local or a long-distance phenomenon.
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CONTINENT-ISLAND MODEL OF MIGRATION Alleles from the continent represent a large fraction of the island gene pool. Alleles from the island have negligible effect on gene frequencies in the continent. CONTINENT ISLAND
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THE HOMOGENIZING EFFECT OF MIGRATION IN A CONTINENT-ISLAND SYSTEM Let: Frequency of A on island = pI Frequency of A on continent = pC Proportion of island population from the continent = m Frequency of A on the island after migration: pI* = (1-m)pI + mpC Change on island from one generation to the next: pI = pI* - pI = (1-m)pI + mpC –pI At equilibrium: pI = pC
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Case Study: Lake Erie Water Snakes FROM: King & Lawson (1995) Distribution on islands in Lake Erie Frequency of color patterns on mainland and offshore islands. Banded Form Solid Form Nerodia sipedon
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MIGRATION – SELECTION BALANCE If the migration rate (m) is << selection (s), In King & Lawsons Water snakes, pc(Banded allele) = 1, s  0.16, and m  0.01 The equilibrium frequency is approximately,
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GENETIC DRIFT Alteration of gene frequencies due to chance (stochastic) effects. Most important in small populations. Tends to reduce genetic variation as the result of extinction of alleles. Generally does not produce a fit between organism and environment; can, in fact, result in nonadaptive or maladaptive changes.
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Genetic drift results from random sampling error Sampling error is higher with smaller sample
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Drift reduces genetic variation in a population Alleles are lost at a faster rate in small populations When all alternative alleles have been lost, one allele becomes fixed in the population
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COALESCENCE THEORY We can trace the descendents of a gene just like a haploid organism. If we look back in time, all of the current gene copies shared a single common ancestor. THE GENEALOGY OF THE PRESENT SEQUENCES COALESCES TO A SINGLE COMMON ANCESTOR. This process is due to the random extinction of lineages. Eventually, in the absence of new mutation, coalescence will result in the fixation of a single allele in the population.
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GENETIC DRIFT IN REPLICATED POPULATIONS: SIMULATION (N = 16) NUMBER OF POPULATIONS GENERATIONS NUMBER OF COPIES OF ALLELE 1
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DISTRIBUTION OF ALLELES IN REPLICATED DROSOPHILA POPULATIONS (107 POPS WITH N = 16) FROM: Buri 1956
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EFFECT OF GENETIC DRIFT ON GENETIC DIVERSITY Genetic drift leads to a reduction in heterozygosity. FROM: Buri 1956
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LOSS OF HETEROZYGOSITY IN A RANDOM MATING POPULATION OF N ADULTS The rate of loss of heterozygosity per generation is equal to the probability that a newborn contains two alleles at a locus that are identical-by-descent from the previous generation, = 1/(2N) Heterozygosity after 1 generation at size N,
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Heterozygosity after t generations at size N, Example: After t = 6N generations, e-t/(2N) = 0.05, implying that 95% of the original heterozygosity has been lost. This is 60 generations for a population size of 10 breeding adults.
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LOSS OF HETEROZYGOSITY VS. POPULATION SIZE
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Effective population size (Ne): the number of individuals in an ideal population (in which every individual reproduces) in which the rate of genetic drift would be the same as it is in the actual population. The rate of genetic drift is highly influenced by the lowest population size in a series of generations. The effective population size (Ne) over multiple generations is best represented by the harmonic mean not the arithmetic mean. RATE OF GENETIC DRIFT AND FLUCTUATIONS IN POPULATION SIZE
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RATE OF GENETIC DRIFT AND FLUCTUATIONS IN POPULATION SIZE Example: Suppose a population went through a bottleneck as follows: N0 =1000, N1 = 10, N2 = 1000 What is the effective size (Ne) of this population across all three generations?
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HARMONIC MEAN: 1/Ne = (1/3)(1/1000 + 1/10 + 1/1000) = 0.034 Ne = 29.4 ARITHMETIC MEAN: Ne = (1/3)(1000 + 10+ 1000) = 670 RATE OF GENETIC DRIFT AND FLUCTUATIONS IN POPULATION SIZE
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GENETIC EFFECTIVE POPULATION SIZE (NE) The effective population size is often << than the actual census size Ne << Na Consider a sexual population consisting of Nm males and Nf females The actual size is, Na = Nm + Nf but, The effective size is,
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Equal Sex Ratio Nm = Nf = 50 For a population of Na = 100 EFFECTIVE SIZE PERCENT FEMALE
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EFFECT OF GENETIC DRIFT ON GENETIC DIVERSITY Genetic drift leads to a reduction in heterozygosity. FROM: Buri 1956 Ne = 16 Ne = 9
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Natural selection more powerful in large populations Drift weaker in large populations Small advantages in fitness can lead to large changes over the long term
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GENETIC DRIFT How can random genetic drift cause maladaptive evolution? Since genetic drift can cause allele frequencies to increase, even deleterious alleles can be advanced and fixed in populations. The result is a decrease in mean population fitness. Small populations are especially prone to this effect. If s < 1/Ne The effects of drift will dominate the dynamics of allele frequency change from one generation to the next.