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Combinatorial chemistry PowerPoint Presentation

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Description : Check out this medical presentation titled "Combinatorial chemistry", to know about Combinatorial chemistry.

Tags : Combinatorial chemistry

Published on : Jul 20, 2021 | Views : 2040 | Downloads : 1

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Slide 1-

Combinatorial chemistry The basic principles
Slide 2-

What is it about? Synthesising a large number of similar compounds in a short period of time. Compounds that are generated are analogues of compounds that are already biologically active Chemists want to find a new medicine that is more effective than an existing one, or causes fewer side effects
Slide 3-

A simple model Take some beads made from a polymer 2. React the beads with a group called a linker 3. Mix the bead in with an alcohol that you want to use in a chemical reaction. The linker will bind to it and hold it on the bead.
Slide 4-

A simple model Have 6 reaction vessels each containing a different acyl chloride. Put a 1/6 of your beads into a mesh bag and put into a container.
Slide 5-

A simple model Esterification occurs forming 6 different esters. 6. The beads are removed from the vessel by lifting up the mesh bag. They are washed to remove any unreacted acyl chloride
Slide 6-

A simple model 7. A reaction is used to break the linker group down. 8. The polymer beads are reused 9. You have made 6 different esters which can now be tested for biological activity
Slide 7-

A simple model 10. How many esters would you have made if you had attached 6 different alcohols to the beads?
Slide 8-

A simple model Large numbers of similar compounds have been synthesised in a very short period of time. Imagine how much longer it would take if you did the reaction with one alcohol and acyl chloride, and then did it again with a different acyl chloride, and then again, and again…. 36 times!

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About : Professor, College of Nursing and Health Sciences
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Specialty : MD
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