Download Free Medical Atherosclerosis PowerPoint Presentation

Atherosclerosis PowerPoint Presentation

DOWNLOAD MEDICAL POWERPOINT PRESENTATION

About This Presentation

Description : Check out this medical presentation on Atherosclerosis, which is titled "Atherosclerosis", to know about atherosclerosis, a specific type of arteriosclerosis (thickening & hardening of arterial walls) affecting primarily the intima of large and medium-sized muscular arteries. It is a chronic inflammatory response in the walls of arteries.

Tags : Atherosclerosis, arteriosclerosis, arterial walls, intima, large, medium-sized muscular arteries, chronic inflammatory response, walls of arteries

Published on : Jun 02, 2021 | Views : 4951 | Downloads : 16

Shareable Url :

Embed Code :

Comment

Transcript

Slide 1-

Atherosclerosis CVS lecture 2 Atherosclerosis
Slide 2-

Vessel wall structure
Slide 3-

Atherosclerosis Atherosclerosis is a specific type of arteriosclerosis (thickening & hardening of arterial walls) affecting primarily the intima of large and medium-sized muscular arteries. Chronic inflammatory response in the walls of arteries. Slowly progressive. A build-up of fat (cholesterol) within the artery wall. Characterized by intimal lesions called: atheromas, atheromatous or fibrofatty plaques
Slide 4-

Atherosclerosis Common sites Abdominal aorta Coronaries Popliteal artery The internal carotid arteries The vessels of the circle of Willis
Slide 5-

Atherosclerosis Risk factors
Slide 6-

LDL Vs. HDL LDL cholesterol : deliver cholesterol to peripheral tissues. HDL, "good cholesterol“: mobilizes cholesterol from developing and existing atheromas and transports it to the liver for excretion in the bile
Slide 7-

Pathogenesis of Atherosclerosis •Cause? - Current hypothesis: Response to Injury - Initiated by endothelial dysfunction •–The main component of fibro-fatty plaque are: Lipid containing macrophages Extracellular matrix Cells, Proliferating smooth muscle cells
Slide 8-

Atherosclerosis Pathogenesis Response-to-injury hypothesis Endothelial injury Not completely understood Nevertheless, the two most important causes of endothelial dysfunction are: Hemodynamic disturbances (HTN) Hypercholesterolemia Inflammation is also an important contributor.
Slide 9-

Response to injury hypothesis Injury to the endothelium (dysfunctional endothelium) Chronic inflammatory response Migration of SMC from media to intima Proliferation of Smooth Ms Cells in intima Excess production of Extra cellular Matrix Enhanced lipid accumulation
Slide 10-

Evolution of arterial wall changes in the response to injury hypothesis. Normal. Endothelial injury with adhesion of monocytes and platelets (the latter to sites where endothelium has been lost). Migration of monocytes and smooth muscle cells into the intima.
Slide 11-

Smooth muscle cell proliferation in the intima with ECM production. Well-developed plaque
Slide 12-

ppt slide no 12 content not found
Slide 13-

Fatty streak, a collection of foamy macrophages in the intima. A, Aorta with fatty streaks (arrows), associated largely with the ostia of branch vessels. B, Intimal, macrophage-derived foam cells
Slide 14-

Plaques vary from 0.3 to 1.5 cm in diameter, but can coalesce to form larger masses
Slide 15-

Atherosclerosis Consequences
Slide 16-

Atherosclerosis Clinical Complications Myocardial infarction (heart attack) Cerebral infarction (stroke) Aortic aneurysms Mesentric occlusion Peripheral vascular disease (gangrene of the legs)
Slide 17-

Morphological changes that are seen on macro and microscopic levels in atherosclerosis Neovascularization (formation of new blood vessels) Calcification Hemorrhage Fissure Ulcer Thrombosis Medial thinning Cholesterol microemboli Aneurysmal dilatation
Slide 18-

Neovascularisation Calcification Inflam. cells Elastin membrane destroyed Fibrous cap Cholesterol clefts