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Antifungal drugs PowerPoint Presentation

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Description : Check out this medical titled "Antifungal drugs”.

This medical is about antifungal drugs, a class of medications used to treat fungal infections. Fungal infections can affect various parts of the body, including the skin, nails, mouth, throat, and genital area. They can be caused by various types of fungi, including yeast, molds, and dermatophytes.

Several classes of antifungal drugs include Azoles, Polyenes, Allylamines, Echinocandins, and Griseofulvin.

The choice of antifungal drug will depend on the type of fungal infection, the severity of the infection, the patients overall health, and any potential drug interactions or side effects. Antifungal drugs can be administered orally, topically, or intravenously, depending on the location and severity of the infection. It is important to follow the prescribed dosage and duration of treatment to ensure effective and safe use of these medications.

Tags : Antifungal drugs, fungal infections, yeast, molds, dermatophytes, Azoles, Polyenes, Allylamines, Echinocandins, Griseofulvin, Infectious Disease, Infectious Disease

Published on : Jun 01, 2023 | Views : 1794 | Downloads : 5

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Antifungal drugs By S.Bohlooli, PhD School of Medicine, Ardabil University of Medical Sciences
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Targets of antifungal drugs
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Model for Amphotericin B induced Pore in Cell Membrane
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Antifungal spectrum and resistance -Antifungal spectrum includes: Histoplasma capsulatus Coccidioides immitis Paracoccidioidoides braziliensis Aspergillus fumigatus Blastomyces dermatitidis Cryptococcus neoformans Candida albicans Sporothrix schenckii Mucor and Rhizopus spp Resistance may occur but is very rare
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Pharmacokinetics -F(oral): < 1% (too irritant to be given IM) -Distribution in all body tissues, except CNS and eye (concentrations in CSF are <10% than in plasma; however therapeutic concentrations in CNS can usually be achieved with parenteral administration) -Biotransformation: > 95% -Renal excretion: < 5% -Half life: » 14 days Drug formulations and administration -Formulations: a) complex with deoxycholate b) liposomal complex (adverse effects seem diminished) -Administration: IV infusion, intrathecal, topical, oral (to treat intestinal mycoses)
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Action of flucytosine in fungi. 5-Flucytosine is transported into the fungal cell, where it is deaminated to 5-fluorouracil (5-FU). The 5-FU is then converted to 5-fluorouracil-ribose monophosphate (5-FUMP) and then is either converted to 5-FUTP and incorporated into RNA or converted by ribonucleotide reductase to 5-FdUMP, which is a potent inhibitor of thymidylate synthase.
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Pharmacologic properties of five systemic azole drugs
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Echinocandins Newest class of antifungal agents Intravenous inhibiting the synthesis of (1–3)-glucan Well tolerated Caspofungin Micafungin Anidulafungin
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