Download Free Medical Antifungal drugs PowerPoint Presentation

Antifungal drugs PowerPoint Presentation

DOWNLOAD MEDICAL POWERPOINT PRESENTATION

About This Presentation

Description : Check out this medical titled "Antifungal drugs”.

This medical is about antifungal drugs, a class of medications used to treat fungal infections. Fungal infections can affect various parts of the body, including the skin, nails, mouth, throat, and genital area. They can be caused by various types of fungi, including yeast, molds, and dermatophytes.

Several classes of antifungal drugs include Azoles, Polyenes, Allylamines, Echinocandins, and Griseofulvin.

The choice of antifungal drug will depend on the type of fungal infection, the severity of the infection, the patients overall health, and any potential drug interactions or side effects. Antifungal drugs can be administered orally, topically, or intravenously, depending on the location and severity of the infection. It is important to follow the prescribed dosage and duration of treatment to ensure effective and safe use of these medications.

Tags : Antifungal drugs, fungal infections, yeast, molds, dermatophytes, Azoles, Polyenes, Allylamines, Echinocandins, Griseofulvin, Infectious Disease, Infectious Disease

Published on : Jun 01, 2023 | Views : 2231 | Downloads : 5

Shareable Url :

Embed Code :

Comment

Transcript

Slide 1-

Antifungal drugs By S.Bohlooli, PhD School of Medicine, Ardabil University of Medical Sciences
Slide 2-

ppt slide no 2 content not found
Slide 3-

Targets of antifungal drugs
Slide 4-

ppt slide no 4 content not found
Slide 5-

ppt slide no 5 content not found
Slide 6-

Model for Amphotericin B induced Pore in Cell Membrane
Slide 7-

Antifungal spectrum and resistance -Antifungal spectrum includes: Histoplasma capsulatus Coccidioides immitis Paracoccidioidoides braziliensis Aspergillus fumigatus Blastomyces dermatitidis Cryptococcus neoformans Candida albicans Sporothrix schenckii Mucor and Rhizopus spp Resistance may occur but is very rare
Slide 8-

Pharmacokinetics -F(oral): < 1% (too irritant to be given IM) -Distribution in all body tissues, except CNS and eye (concentrations in CSF are <10% than in plasma; however therapeutic concentrations in CNS can usually be achieved with parenteral administration) -Biotransformation: > 95% -Renal excretion: < 5% -Half life: » 14 days Drug formulations and administration -Formulations: a) complex with deoxycholate b) liposomal complex (adverse effects seem diminished) -Administration: IV infusion, intrathecal, topical, oral (to treat intestinal mycoses)
Slide 9-

ppt slide no 9 content not found
Slide 10-

ppt slide no 10 content not found
Slide 11-

ppt slide no 11 content not found
Slide 12-

Action of flucytosine in fungi. 5-Flucytosine is transported into the fungal cell, where it is deaminated to 5-fluorouracil (5-FU). The 5-FU is then converted to 5-fluorouracil-ribose monophosphate (5-FUMP) and then is either converted to 5-FUTP and incorporated into RNA or converted by ribonucleotide reductase to 5-FdUMP, which is a potent inhibitor of thymidylate synthase.
Slide 13-

ppt slide no 13 content not found
Slide 14-

ppt slide no 14 content not found
Slide 15-

ppt slide no 15 content not found
Slide 16-

ppt slide no 16 content not found
Slide 17-

ppt slide no 17 content not found
Slide 18-

Pharmacologic properties of five systemic azole drugs
Slide 19-

ppt slide no 19 content not found
Slide 20-

ppt slide no 20 content not found
Slide 21-

ppt slide no 21 content not found
Slide 22-

Echinocandins Newest class of antifungal agents Intravenous inhibiting the synthesis of (1–3)-glucan Well tolerated Caspofungin Micafungin Anidulafungin
Slide 23-

ppt slide no 23 content not found
Slide 24-

ppt slide no 24 content not found
Slide 25-

ppt slide no 25 content not found
Slide 26-

ppt slide no 26 content not found
Slide 27-

ppt slide no 27 content not found
Slide 28-

ppt slide no 28 content not found